Results 1 to 10 of about 12,717 (149)

Orexin Signaling: A Complex, Multifaceted Process

Frontiers in Cellular Neuroscience, 2022
The orexin system comprises two G protein-coupled receptors, OX1 and OX2 receptors (OX1R and OX2R, respectively), along with two endogenous agonists cleaved from a common precursor (prepro-orexin), orexin-A (OX-A) and orexin-B (OX-B).
Natasha C. Dale, Natasha C. Dale, Natasha C. Dale, Daniel Hoyer, Daniel Hoyer, Daniel Hoyer, Laura H. Jacobson, Laura H. Jacobson, Laura H. Jacobson, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone   +16 more
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Intra-periaqueductal Grey Matter Injection of Orexin A Attenuates Nitroglycerin-induced Deficits in Learning and Memory in Male Rats [PDF]

The Iranian Journal of Veterinary Science and Technology, 2023
This study explored the potential contribution of Orx1R within vlPAG to the learning and memory of animals with chronic migraine-like pain. Migraine was induced by repeated i.p. administration of nitroglycerin (5 mg/kg).
Razieh Kooshki, Mehdi Abbasnejad, Baharosadat Majdzadeh   +2 more
doaj   +1 more source

Subcutaneous adipose tissue browning, serum orexin-A, and insulin resistance following aerobic exercise in high-fat diet obesity male wistar rats

International Journal of Preventive Medicine, 2021
Background: Subcutaneous adipose tissue (SAT) relative to the other adipose tissues may have different roles in health and insulin resistance. The purpose of this study was to investigate the effectiveness of aerobic exercise on SAT thermogenesis indices,
Ebrahim Moslehi, Vazgen Minasian, Heibatollah Sadeghi   +2 more
doaj   +1 more source

A photocaged orexin-B for spatiotemporally precise control of orexin signaling

Cell Chemical Biology, 2022
Orexin neuropeptides carry out important neuromodulatory functions in the brain, yet tools to precisely control the activation of endogenous orexin signaling are lacking. Here, we developed a photocaged orexin-B (photo-OXB) through a C-terminal photocaging strategy.
Duffet, Loic, Tatarskiy, Petr V, Harada, Masaya, Williams, Elyse T, Hartrampf, Nina, Patriarchi, Tommaso   +5 more
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Orexin receptor expression in human adipose tissue: effects of orexin-A and orexin-B [PDF]

Journal of Endocrinology, 2006
Orexin-A and orexin-B, via their receptors orexin-1 receptor (OX1R) and orexin-2 receptor (OX2R) have been shown to play a role in the regulation of feeding, body weight, and energy expenditure. Adipose tissue also contributes significantly to the maintenance of body weight by interacting with a complex array of bioactive peptides; however, there are ...
J E, Digby, J, Chen, J Y, Tang, H, Lehnert, R N, Matthews, H S, Randeva   +5 more
openaire   +2 more sources

Involvement of the Orexinergic System in Feeding

Applied Sciences, 2021
To know the processes involved in feeding, the dysregulation of hypothalamic neuropeptides promoting anorexigenic/orexigenic mechanisms must be investigated. Many neuropeptides are involved in this behavior and in overweight/obesity.
Pilar Marcos, Rafael Coveñas
doaj   +1 more source

Research progress on the mechanism of orexin in pain regulation in different brain regions

Open Life Sciences, 2021
Orexin is a neuropeptide that is primarily synthesized and secreted by the lateral hypothalamus (LH) and includes two substances derived from the same precursor (orexin A [OXA] and orexin B [OXB]).
Kang Xianhui, Tang Hongli, Liu Yao, Yuan Yan, Wang Mi   +4 more
doaj   +1 more source

Merkel cells, a new localization of prepro‐orexin and orexin receptors [PDF]

Journal of Anatomy, 2004
AbstractOrexins (OXA and OXB) are peptides derived from a common precursor called prepro‐orexin. They act through G‐protein receptors named orexin 1 receptor (OX1R) and orexin 2 receptor (OX2R). Orexins were first demonstrated in neurons of the lateral hypothalamus and found to be related to the control of food intake.
Andrés, Beiras-Fernández, Rosalía, Gallego, Montserrat, Blanco, Tomás, García-Caballero, Carlos, Diéguez, Andrés, Beiras   +5 more
openaire   +2 more sources

Orexin-A exerts neuroprotective effect in experimental intracerebral hemorrhage by suppressing autophagy via OXR1-mediated ERK/mTOR signaling pathway

Frontiers in Cellular Neuroscience, 2022
BackgroundOrexin-A (OXA) is a polypeptide produced in the hypothalamus, which binds to specific receptors and exerts multiple physiological effects. Autophagy plays a vital role in early brain injury (EBI) after intracerebral hemorrhage (ICH).
Dexin Zhang, Ying Cui, Manman Zhao, Xuecheng Zheng, Chunyan Li, Jingbo Wei, Kaijie Wang, Jianzhong Cui, Jianzhong Cui   +8 more
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The role of orexin A in pathophysiological mechanisms of sleep disorder in postmenopausal women

Гинекология, 2020
Aim. To conduct a comparative analysis of serum orexin A levels in women of different age periods with and without sleep disorder and vasomotor symptoms. To evaluate the dynamics of orexin A levels under menopausal hormone therapy.
Zukhra Kh. Ebzieva, Svetlana V. Yureneva, Tatiana Yu. Ivanets   +2 more
doaj   +1 more source