Results 121 to 130 of about 20,577 (234)

An alerting structure: human orexin receptor 1

Nature Structural & Molecular Biology, 2016
[No abstract available]
Daniel, Wacker, Bryan L, Roth
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Targeting Orexin Receptors for the Treatment of Insomnia: From Physiological Mechanisms to Current Clinical Evidence and Recommendations

Nature and Science of Sleep, 2023
Maria P Mogavero,1,2,* Alessandro Silvani,3,* Giuseppe Lanza,4,5 Lourdes M DelRosso,6 Luigi Ferini-Strambi,1,2 Raffaele Ferri4 1Vita-Salute San Raffaele University, Milan, Italy; 2Sleep Disorders Center, Division of Neuroscience, San Raffaele ...
Mogavero MP, Silvani A, Lanza G, DelRosso LM, Ferini-Strambi L, Ferri R   +5 more
doaj  

The piranha genome provides molecular insight associated to its unique feeding behavior [PDF]

, 2019
The piranha enjoys notoriety due to its infamous predatory behavior but much is still not understood about its evolutionary origins and the underlying molecular mechanisms for its unusual feeding biology.
Adolfi, Mateus, Fischer, Petra, Kneitz, Susanne, Meyer, Axel, Minx, Patrick, Schartl, Manfred, Schmidt, Cornelia, Tomlinson, Chad, Volkoff, Helene, Warren, Wesley C   +9 more
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Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulators

Frontiers in Neuroscience, 2013
Dual orexin receptor antagonists (DORAs) are a potential treatment for insomnia that function by blocking both the orexin 1 and orexin 2 receptors. The objective of the current study was to further confirm the impact of therapeutic mechanisms targeting ...
Andres D. Ramirez, Anthony L. Gotter, Steven V. Fox, Pamela L. Tannenbaum, Lihang eYao, Spencer J. Tye, Terrence eMcDonald, Joseph eBrunner, Susan L. Garson, Duane R. Reiss, Scott D. Kuduk, Paul J. Coleman, Jason M. Uslaner, Robert eHodgson, Susan E. Browne, John J. Renger, Christopher J. Winrow   +16 more
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Orexins in apoptosis: a dual regulatory role

Frontiers in Cellular Neuroscience
The orexins, also referred to as hypocretins, are neuropeptides that originate from the lateral hypothalamus (LH) region of the brain. They are composed of two small peptides, orexin-A, and orexin-B, which are broadly distributed throughout the central ...
Simona Cavalu, Sameh Saber, Rabab S. Hamad, Rabab S. Hamad, Mustafa Ahmed Abdel-Reheim, Mustafa Ahmed Abdel-Reheim, Elsayed A. Elmorsy, Elsayed A. Elmorsy, Mahmoud E. Youssef   +8 more
doaj   +1 more source

Multiple signaling pathways of orexin receptors

SpringerPlus, 2015
Orexin/hypocretin peptides are central for the regulation of the sleep/arousal states, and have, in addition, a role in the regulation of e.g. metabolism, addiction, stress response and pain gating. Orexin responses are mediated by G-protein-coupled OX1 and OX2 orexin receptors. Orexin signaling (in different cell types) is very versatile, ranging from
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374 Targeting disrupted neural circuits to treat PTSD with comorbid psychosis

Journal of Clinical and Translational Science
Objectives/Goals: To define how stress alters dopamine system function in PTSD with comorbid psychosis and determine whether orexin receptor antagonism with suvorexant can normalize dopamine neuron activity by targeting the insular cortex–orbitofrontal ...
Olivia Yang, Hannah B. Elam, Stephanie M. Perez, Daniel J. Lodge   +3 more
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In Vitro Signaling Properties of Cannabinoid and Orexin Receptors: How Orexin Receptors Influence Cannabinoid Receptor‐Mediated Signaling

Pharmacology Research & Perspectives
ABSTRACTThe co‐expression of different types of G protein‐coupled receptors (GPCRs) in the same cells can have implications for receptor signaling and receptor cross‐talk, potentially altering the apparent potency or efficacy of ligands targeting each receptor.
Kawthar A. Mohamed, Robert B. Laprairie
openaire   +3 more sources

Hypocretin underlies the evolution of sleep loss in the Mexican cavefish [PDF]

, 2018
The duration of sleep varies dramatically between species, yet little is known about the genetic basis or evolutionary factors driving this variation in behavior. The Mexican cavefish, Astyanax mexicanus, exists as surface populations that inhabit rivers,
Duboue, Erik R., Jaggard, James B., Keene, Alex C., Lloyd, Evan, Prober, David A., Stahl, Bethany A.   +5 more
core   +1 more source

Mapping a Novel Hedonic Hotspot in the Orbitofrontal Cortex [PDF]

, 2014
Honors (Bachelor's)PsychologyUniversity of Michiganhttp://deepblue.lib.umich.edu/bitstream/2027.42/107703/1/mikewkh ...
Wu, Kuan Hua
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