Results 131 to 140 of about 20,577 (234)

Chemical stimulation of the lateral hypothalamus potentiated the sensitization to morphine in rats [PDF]

, 2014
Orexin plays a crucial role in drug-seeking behavior. The lateral hypothalamus (LH) is a central region that produces orexin, and its projections to the ventral tegmental area (VTA) play an important role in reward and addiction-related behaviors.
Bani-Ardalan, Mahtash, Haghparast, Abbas, Karimi, Sara, Razavi, Yasaman   +3 more
core  

Role of Orexin in the Tolerance and Physical Dependence to Morphine

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2014
BACKGROUND AND OBJECTIVE: Although opioid drugs cause analgesia and more effective in treatment of pain but, its utility is hindered by the development of tolerance to its analgesic effects.
Samad Nazemi, Hassan Azhdari zarmrhri, Hashem Haghdoost-Yazdi   +2 more
doaj  

Orexin Receptor Antagonist [PDF]

, 2020
openaire   +1 more source

Unilateral Hypothalamus Inactivation Prevents PTZ Kindling Development through Hippocampal Orexin Receptor 1 Modulation

Basic and Clinical Neuroscience, 2014
Introduction: Epilepsy is a neural disorder in which abnormal plastic changes during short and long term periods lead to increased excitability of brain tissue.
Nasibe Akbari, Mahmoud Elahdadi Salmani, Mahdi Goudarzvand, Taghi LashkarBoluki, Iran Goudarzi, Kataneh Abrari   +5 more
doaj  

Investigation of a simple suspension method for orexin receptor antagonist tablets. [PDF]

J Pharm Health Care Sci
Hada K, Inoue D, Ohishi K, Yasunaga T, Ozeki K, Yamamoto H, Nakamura N.   +6 more
europepmc   +1 more source

Optimal use of dual orexin receptor antagonists for insomnia: a network meta-analysis perspective. [PDF]

Transl Psychiatry
Kishi T, Ikuta T, Hatano M, Kato-Matsukawa S, Iwata N.   +4 more
europepmc   +1 more source

Orexin receptor 2 agonists: a pathophysiologic approach to narcolepsy type 1. [PDF]

Ann Med Surg (Lond)
Arif Z, Siddiqui E, Hujjat SFZ, Khan MS, Mauhmoud A.   +4 more
europepmc   +1 more source

Integrative physiology of orexins and orexin receptors.

Integrative physiology of orexins and orexin receptors.
Recent studies have established that the orexin system is a critical regulator of sleep/wake states. Deficiency of orexin signaling results in the sleep disorder narcolepsy-cataplexy in humans, dogs, and rodents. These findings have brought about the possibility of novel therapies for sleep disorders including narcolepsy-cataplexy.
openaire  

Orexin Receptor Antagonism Improves Sleep Quality and Mitigates Lipopolysaccharide-Induced Inflammatory Responses in a Mouse Model. [PDF]

FASEB J
Horiuchi D, Irukayama-Tomobe Y, Kim JD, Kasuya Y, Nemoto T, Suzuki T, Nakagawa Y, Tatsumi K.   +7 more
europepmc   +1 more source

Found in translation: orexin receptor antagonism for the treatment of opioid use disorder. [PDF]

Transl Psychiatry
Raymond JS, Vareed RD, Peters J, James MH.   +3 more
europepmc   +1 more source