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Orexins and Orexin Receptors: From Molecules to Integrative Physiology
2008Recent studies have implicated the orexin system as a critical regulator of sleep/wake states, feeding behavior, and reward processes. Orexin deficiency results in narcolepsy-cataplexy in humans, dogs, and rodents, suggesting that the orexin system is particularly important for maintenance of wakefulness.
Taizo, Matsuki, Takeshi, Sakurai
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2016
Orexin or hypocretin; a peptide that resembles the molecular structure of the gastric peptide secretin, was discovered in 1996 by two independent groups of researchers. One group named it orexin after the Greek word orexis which means “appetite,” while the other group named it hypocretin since it was synthesized in the hypothalamus and resembles ...
Patkar, Omkar L. +2 more
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Orexin or hypocretin; a peptide that resembles the molecular structure of the gastric peptide secretin, was discovered in 1996 by two independent groups of researchers. One group named it orexin after the Greek word orexis which means “appetite,” while the other group named it hypocretin since it was synthesized in the hypothalamus and resembles ...
Patkar, Omkar L. +2 more
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Orexin receptors as therapeutic drug targets
2012Orexin (hypocretin) receptor antagonists stand as a model for the development of targeted CNS small-molecule therapeutics. The identification of mutations in the gene for the orexin 2 receptor responsible for canine narcolepsy, the demonstration of a hypersomnolence phenotype in hypocretin knockout mice and the disruption in orexin signaling in ...
Anthony L, Gotter +5 more
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Bioorganic & Medicinal Chemistry Letters, 2017
In an ongoing effort to explore the use of orexin receptor antagonists for the treatment of insomnia, dual orexin receptor antagonists (DORAs) were structurally modified, resulting in compounds selective for the OX2R subtype and culminating in the discovery of 23, a highly potent, OX2R-selective molecule that exhibited a promising in vivo profile ...
Jason W, Skudlarek +20 more
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In an ongoing effort to explore the use of orexin receptor antagonists for the treatment of insomnia, dual orexin receptor antagonists (DORAs) were structurally modified, resulting in compounds selective for the OX2R subtype and culminating in the discovery of 23, a highly potent, OX2R-selective molecule that exhibited a promising in vivo profile ...
Jason W, Skudlarek +20 more
openaire +2 more sources
Oral Orexin Receptor 2 Agonist in Narcolepsy Type 1
New England Journal of Medicine, 2023Rafael del Río-Villegas
exaly
Orexin neurons inhibit sleep to promote arousal
Nature Communications, 2022Roberto De Luca, Anne Venner, Dong Kong
exaly
[Roles of orexin and effects of orexin receptor antagonists].
Nihon rinsho. Japanese journal of clinical medicine, 2015Orexin A and orexin B are hypothalamic neuropeptides that were discovered in 1998. Several studies suggested that orexin deficiency causes narcolepsy in humans and other mammalian species, highlighting roles of this hypothalamic neuropeptide in the regulation of sleep and wakefulness.
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