Results 61 to 70 of about 1,034,083 (358)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

An improved organ explant culture method reveals stem cell lineage dynamics in the adult Drosophila intestine

eLife, 2022
In recent years, live-imaging techniques have been developed for the adult midgut of Drosophila melanogaster that allow temporal characterization of key processes involved in stem cell and tissue homeostasis.
Marco Marchetti, Chenge Zhang, Bruce A Edgar   +2 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

EXPERIMENTAL MORPHOLOGICAL RESEARCHES IN BIOCOMPATIBILITY OF POLYMER INTRA-CORNEAL LENSES WITH THE HUMAN CORNEA EX VIVO

Офтальмохирургия, 2017
Purpose. To investigate in an experimental and morphological ex vivo research a tissue reaction of human cadaver donor cornea to the implantation of intra-corneal lenses (ICL)Material and methods.
B. E. Malyugin, S. A. Borzenok, I. A. Mushkova, N. V. Shevlyagina, Y. V. Shkandina, D. S. Ostrovsky, I. A. Popov   +6 more
doaj  

Effect of Exogenous Plant Growth Regulators on Antioxidant Defense in Zucchini Cotyledons Under Different Light Regimes

Agriculture
Epigeal cotyledons with excised embryonic axes are often used as a model system to study the processes of cell division and expansion. These processes are regulated by diverse phytohormones and signaling molecules.
Asya Petrova, Zornitsa Katerova, Iskren Sergiev, Dessislava Todorova   +3 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Evaluation of the effects of titanium dioxide nanoparticles on cultured Rana catesbeiana tailfin tissue

Frontiers in Genetics, 2013
Nanoparticles (NPs), materials that have one dimension less than 100 nm, are used in manufacturing, health and food products, and consumer products including cosmetics, clothing and household appliances.
S. Austin eHammond, Amanda eCarew, Caren eHelbing   +2 more
doaj   +1 more source

Development of ex vivo organ culture models to mimic human corneal scarring [PDF]

, 2012
PURPOSE: To develop ex vivo organ culture models of human corneal scarring suitable for pharmacological testing and the study of the molecular mechanisms leading to corneal haze after laser surgery or wounding.
Damour, O, Galiacy, SD, Hulmes, DJ, Janin-Manificat, H, Malecaze, F, Moali, C, Rovère, MR   +6 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Estabelecimento de um protocolo regenerativo para a micropropagação do abacaxizeiro Establishment of a regenerative protocol for the pineapple micropropagation

Pesquisa Agropecuária Brasileira, 1999
No Laboratório de Fisiologia do Desenvolvimento e Genética Vegetal do CCA-UFSC, nos anos de 1993 a 1996, foram testadas 24 combinações de tratamentos envolvendo dois genótipos de abacaxizeiro (Ananas comosus (L.) Merr.), seis combinações dos ...
Miguel Pedro Guerra, Lírio Luiz Dal Vesco, Rosete Pescador, Adilson Ricken Schuelter, Rubens Onofre Nodari   +4 more
doaj   +1 more source