Results 31 to 40 of about 59,063 (155)
Breaking the clean room barrier: exploring low-cost alternatives for microfluidic devices
Frontiers in Bioengineering and Biotechnology, 2023 Microfluidics is an interdisciplinary field that encompasses both science and engineering, which aims to design and fabricate devices capable of manipulating extremely low volumes of fluids on a microscale level. The central objective of microfluidics is
Cristian F. Rodríguez +6 more
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Organs-on-chip: The way forward [PDF]
Stem Cell Reports, 2021 Organ-on-chip (OoC) technology is thriving thanks to stem cells availability and international OoC programs. Concerted standardization, qualification, and independent testing of devices are needed to coherently develop OoC technology further and fulfill its potential in drug development, disease modeling, and personalized medicine.
Mastrangeli, Massimo +1 more
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Microfluidic Platforms to Unravel Mysteries of Alzheimer’s Disease: How Far Have We Come?
Life, 2021 Alzheimer’s disease (AD) is a significant health concern with enormous social and economic impact globally. The gradual deterioration of cognitive functions and irreversible neuronal losses are primary features of the disease.
Pragya Prasanna +12 more
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Frontiers in Lab on a Chip TechnologiesOrgans-on-chips (OoC) are in vitro models that emulate key functionalities of tissues or organs in a miniaturized and highly controlled manner. Due to their high versatility, OoC have evolved as promising alternatives to animal testing for a more ...
J. Meneses +6 more
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Cells in the 3D biomatrix on-chip: better mimicking the real micro-physiological system
Next MaterialsRecent advances in microfluidic technology and biomaterial science have augmented the use of organ-on-chip (OoC) technology to closely mimic the human pathophysiology.
Michele D’Orazio +7 more
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Current Opinion in Toxicology, 2019 Blood hypercoagulability and thrombosis have been observed in patients during clinical trials of candidate drugs, yet these safety risks are seldom identified during preclinical testing, leading to increased mortality and morbidity, and increased attrition rates in the clinic.
Yunki Lee, Song Ih Ahn, YongTae Kim
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Organ on Chip Technology to Model Cancer Growth and Metastasis
Bioengineering, 2022 Organ on chip (OOC) has emerged as a major technological breakthrough and distinct model system revolutionizing biomedical research and drug discovery by recapitulating the crucial structural and functional complexity of human organs in vitro.
Giorgia Imparato +2 more
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Organs-on-chips: latest developments
Microphysiological Systems, 2019 Welcome to the collection of the current must-read open-access papers in the field of organs-on-chips that have become available in the second half of 2018. This quarterly editorial column will be compiled by Dr. Andries D. van der Meer, University of Twente, The Netherlands.
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Results in EngineeringPoly-L-lactic acid (PLLA) is widely used in medical applications due to its excellent biodegradability and biocompatibility. However, its limited mechanical strength poses challenges for applications like biodegradable stents, which require both strength
Yuanyuan Chen +7 more
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Frontiers in Bioengineering and Biotechnology, 2022 Human Microphysiological Systems (hMPS), otherwise known as organ- and tissue-on-a-chip models, are an emerging technology with the potential to replace in vivo animal studies with in vitro models that emulate human physiology at basic levels.
Raquel E. Ajalik +11 more
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