Results 41 to 50 of about 59,063 (155)
Organs-on-chips: a decade of innovation
Trends in Biotechnology, 2023 Recreating 'living organs' with groundbreaking organ-on-a-chip (OOC) technologies is facilitating a new era of drug discovery. Studies by Huh et al. and Ronaldson-Bouchard et al. underscore advances made over a decade, spanning single organ functionality to interconnected organs, that enable examination of drug toxicities and disease pathogenesis in ...
Carly Strelez +2 more
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Toxicology Research and Application, 2017 In the last few years, considerable attention has been given to in vitro models in an attempt to reduce the use of animals and to decrease the rate of preclinical failure associated with the development of new drugs. Simple two-dimensional cultures grown in a dish are now frequently replaced by organotypic cultures with three-dimensional (3-D ...
David Bovard +4 more
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Organoids and organ chips in ophthalmology
The Ocular Surface, 2021 Recent advances have driven the development of stem cell-derived, self-organizing, three-dimensional miniature organs, termed organoids, which mimic different eye tissues including the retina, cornea, and lens. Organoids and engineered microfluidic organ-on-chips (organ chips) are transformative technologies that show promise in simulating the ...
Navid Manafi +10 more
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BacteriaMinimally processed foods (MPFs), often considered ready-to-eat, do not undergo cooking and therefore require proper handling and preparation to ensure safety. If not handled correctly, these foods can serve as a pathway for diseases caused by pathogenic
Aline Sitowski +3 more
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Bioprinting of Organ-on-Chip Systems: A Literature Review from a Manufacturing Perspective
Journal of Manufacturing and Materials Processing, 2021 This review discusses the reported studies investigating the use of bioprinting to develop functional organ-on-chip systems from a manufacturing perspective.
Ketan Thakare +5 more
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Health Technology Assessment in Action, 2023 Context: The placenta performs a crucial function in nutrient exchange, but studying this tissue poses a number of challenges. Utilizing microfluidic and microfabrication technologies, a 3D placenta-on-a-chip model provides a biomimetic alternative for ...
Ravindra Kalode, Pranoti Kalode
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3D Printing of Organs-On-Chips [PDF]
Bioengineering, 2017 Organ-on-a-chip engineering aims to create artificial living organs that mimic the complex and physiological responses of real organs, in order to test drugs by precisely manipulating the cells and their microenvironments. To achieve this, the artificial organs should to be microfabricated with an extracellular matrix (ECM) and various types of cells ...
YI, HEE GYEONG +2 more
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Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity
Bioactive Materials, 2021 Despite showing a great promise in the field of nanomedicine, nanoparticles have gained a significant attention from regulatory agencies regarding their possible adverse health effects upon environmental exposure.
Rick Xing Ze Lu, Milica Radisic
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Developments and Applications of Liver-on-a-Chip Technology—Current Status and Future Prospects
BiomedicinesBackground/Objectives: Liver-on-a-chip (LiOC) technology is increasingly recognized as a transformative platform for modeling liver biology, disease mechanisms, drug metabolism, and toxicity screening.
Joseph Mugaanyi +5 more
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Scientific Reports, 2021 The dynamic contrast-enhanced MR imaging plays a crucial role in evaluating the effectiveness of neoadjuvant chemotherapy (NAC) even since its early stage through the prediction of the final pathological complete response (pCR).
Maria Colomba Comes +14 more
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