Results 51 to 60 of about 59,063 (155)
Mimicking and surpassing the xenograft model with cancer-on-chip technology
EBioMedicine, 2021 Organs-on-chips are in vitro models in which human tissues are cultured in microfluidic compartments with a controlled, dynamic micro-environment. Specific organs-on-chips are being developed to mimic human tumors, but the validation of such ‘cancer-on ...
Job Komen +4 more
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Mimicking the Kidney: A Key Role in Organ-on-Chip Development
Micromachines, 2016 Pharmaceutical drug screening and research into diseases call for significant improvement in the effectiveness of current in vitro models. Better models would reduce the likelihood of costly failures at later drug development stages, while limiting or ...
Roberto Paoli, Josep Samitier
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Nature Reviews Drug Discovery, 2021 Organs-on-chips (OoCs), also known as microphysiological systems or ‘tissue chips’ (the terms are synonymous), have attracted substantial interest in recent years owing to their potential to be informative at multiple stages of the drug discovery and development process.
Low, Lucie A. +4 more
openaire +1 more source
Colloids and Surfaces B: BiointerfacesTraditional drug development methods have relied on 2D cell cultures and animal models, which have not been able to adequately represent human biology. Due to genetic and physiological variances in human biology, animal models cannot yield accurate results, whereas 2D cell cultures are insufficient in simulating tissue architecture and cell-to-cell ...
Aarif Ali +6 more
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MicroorganismsPastures serve as the primary source of grass and forage plants for grazing livestock, requiring adequate nutrient input to sustain growth and soil fertility.
Mariana Juca Silva +6 more
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Hemostasis-On-a-Chip: Impedance Spectroscopy Meets Microfluidics for Hemostasis Evaluation
Micromachines, 2019 In the case of vascular injury, a complex process (of clotting) starts, involving mainly platelets and coagulation factors. This process in healthy humans is known as hemostasis, but when it is deregulated (thrombosis), it can be the cause of important ...
Shadi Karimi +4 more
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Organ-on-a-Chip and Lab-on-a-Chip Technologies in Cardiac Tissue Engineering
BiomimeticsMicrofluidic technologies have ushered in a new era in cardiac tissue engineering, providing more predictive in vitro models compared to two-dimensional culture studies. This review examines Organ-on-a-Chip (OoC) and Lab-on-a-Chip (LoC) platforms, with a
Daniele Marazzi +3 more
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A Comprehensive Review of Organ-on-a-Chip Technology and Its Applications
BiosensorsOrgan-on-a-chip (OOC) is an emerging technology that simulates an artificial organ within a microfluidic cell culture chip. Current cell biology research focuses on in vitro cell cultures due to various limitations of in vivo testing.
Negar Farhang Doost +1 more
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Anti-Inflammatory and Regenerative Properties of Herbal Extracts: Wound Management in Equine Models
Drug Target InsightsIntroduction: Wound management presents significant challenges, requiring effective treatments. Herbal extracts have been traditionally used to support healing due to their anti-inflammatory, antimicrobial, and cellregenerative properties. Methods: This
Gustavo Fehrenbach +9 more
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Melanoma-on-a-chip model for anticancer drug injecting delivery method
SLAS TechnologyThe pharmaceutical and cosmetic industries are encountering a challenge in adopting new study models for product development. there has been a growing interest in organ-on-a-chip systems, and particularly for generating skin models.
Pedro Herreros +3 more
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