Results 31 to 40 of about 392,519 (219)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Selected Antioxidants in Organic vs. Conventionally Grown Apple Fruits
Applied Sciences, 2020 The apple (Malus domestica Borkh.) is one of the most widely cultivated temperate fruits globally, gaining scientific interest as a rich source of antioxidants with a demonstrated beneficial human health impact.
Dominika Średnicka-Tober +5 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Geo: Geography and EnvironmentFood system (FS) actors are challenged by multiple barriers and lock‐ins that prevent them from transitioning to productive, climate‐neutral, biodiversity‐friendly, resilient and sustainable food systems (SFS). One approach to addressing these challenges,
Lucija Lapuh +2 more
doaj +1 more source
TECHNOLOGY FOR THE PRODUCTION OF DESSERTS BASED ON GOAT MILK
Шәкәрім университетінің хабаршысы: Техника ғылымдарNowadays, food manufacturers strive to differentiate their products through creative segmentation and positioning strategies, focusing on functionality and quality.
R. K. Makeeva +4 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Mass Spectrometric Analysis of N-Glycome of Patatin Proteins from Three Potato Cultivars
MoleculesAs a vital post-translational modification of potato tuber proteins, N-glycosylation directly regulates protein structural stability, biological activity and processing properties.
Lingmei Li +5 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Data covering soil management practices and farm characteristics on Swiss arable farms
Scientific DataSoil health is the cornerstone of sustainable agriculture, but studies have shown that agricultural soils are degrading due to inadequate soil management practice adoption. To understand the status quo, we surveyed 2,728 Swiss arable farms in 2024.
Charles Rees +3 more
doaj +1 more source