Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
DIGITAL TRANSFORMATION AND ECONOMIC DEINDUSTRIALISATION: IMPACT ON STATE FINANCIAL SECURITY
Фінансово-кредитна діяльність: проблеми теорії та практикиIn the context of global challenges, digital transformation acts as a catalyst for emerging threats and heightened systemic risks, including those associated with premature economic deindustrialisation. Therefore, this study of the interrelationship and
Oleksandra Maslii, Andrii Maksymenko
doaj +1 more source
Work stress and perceived organisational support on young Korean nurses' care for COVID-19 patients. [PDF]
Collegian, 2022 Son YJ, Lee H, Jang SJ.
europepmc +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Hospitality's ethical values and unethical employee behaviour: The mediating roles of work values and the moderating role of perceived organisational support. [PDF]
Front Psychol, 2022 Chen Q, Liu Z.
europepmc +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
The influence of technostress, work-family conflict, and perceived organisational support on workplace flourishing amidst COVID-19. [PDF]
Front Psychol, 2022 Harunavamwe M, Ward C.
europepmc +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Effects of sleep duration, perceived organisational support and personal resilience on anxiety in non-hospitalised residents during the COVID-19 pandemic: a survey study in Ningbo, China. [PDF]
BMJ Open, 2023 Zhang Y +5 more
europepmc +1 more source