Results 11 to 20 of about 77,933 (256)

FBP17-mediated finger-like membrane protrusions in cell competition between normal and RasV12-transformed cells

iScience, 2021
Summary: At the initial stage of carcinogenesis, cell competition often occurs between newly emerging transformed cells and the neighboring normal cells, leading to the elimination of transformed cells from the epithelial layer. For instance, when RasV12-
Tomoko Kamasaki, Yumi Miyazaki, Susumu Ishikawa, Kazuya Hoshiba, Keisuke Kuromiya, Nobuyuki Tanimura, Yusuke Mori, Motosuke Tsutsumi, Tomomi Nemoto, Ryota Uehara, Shiro Suetsugu, Toshiki Itoh, Yasuyuki Fujita   +12 more
doaj   +1 more source

Spatial topology of organelle is a new breast cancer cell classifier

iScience, 2023
Summary: Genomics and proteomics have been central to identify tumor cell populations, but more accurate approaches to classify cell subtypes are still lacking.
Ling Wang, Joshua Goldwag, Megan Bouyea, Jonathan Barra, Kailie Matteson, Niva Maharjan, Amina Eladdadi, Mark J. Embrechts, Xavier Intes, Uwe Kruger, Margarida Barroso   +10 more
doaj   +1 more source

Supracellular Actomyosin Mediates Cell-Cell Communication and Shapes Collective Migratory Morphology

iScience, 2020
Summary: During collective cell migration, front cells tend to extend a predominant leading protrusion, which is rarely present in cells at the side or rear positions.
Heng Wang, Xuan Guo, Xianping Wang, Xiaobo Wang, Jiong Chen   +4 more
doaj   +1 more source

Novel approaches, including systems biology, to HIV vaccine research and development: Report from a Global HIV Vaccine Enterprise Working Group [PDF]

, 2010
The Global HIV Vaccine Enterprise convened a two-day workshop on August 10-11 2009, at the Fred Hutchison Cancer Research Center offices in Seattle, WA, to discuss the application of novel approaches,including systems biology, to HIV vaccine research and
Alan Aderem, Bali Pulendran, Rino Rappuoli, the Working Group convened by the Global HIV Vaccine Enterprise   +3 more
core   +3 more sources

Protease OMA1 modulates mitochondrial bioenergetics and ultrastructure through dynamic association with MICOS complex

iScience, 2021
Summary: Remodeling of mitochondrial ultrastructure is a process that is critical for organelle physiology and apoptosis. Although the key players in this process—mitochondrial contact site and cristae junction organizing system (MICOS) and Optic Atrophy
Martonio Ponte Viana, Roman M. Levytskyy, Ruchika Anand, Andreas S. Reichert, Oleh Khalimonchuk   +4 more
doaj   +1 more source

DNA sequence-directed cooperation between nucleoid-associated proteins

iScience, 2021
Summary: Nucleoid-associated proteins (NAPs) are a class of highly abundant DNA-binding proteins in bacteria and archaea. While both the composition and relative abundance of the NAPs change during the bacterial growth cycle, surprisingly little is known
Aleksandre Japaridze, Wayne Yang, Cees Dekker, William Nasser, Georgi Muskhelishvili   +4 more
doaj   +1 more source

The Evolutionary Reorganization of Ontogeny and Origin of Multicellularity [PDF]

, 2010
The formation of morphogenetic mechanisms during emergence of multicellularity is discussed in this ...
Dovgal, I. V.
core   +1 more source

A quantitative perspective on ethics in large team science [PDF]

, 2014
The gradual crowding out of singleton and small team science by large team endeavors is challenging key features of research culture. It is therefore important for the future of scientific practice to reflect upon the individual scientist's ethical ...
Pavlidis, Ioannis, Petersen, Alexander M., Semendeferi, Ioanna   +2 more
core   +2 more sources

Dynamics of nuclear export of pre-ribosomal subunits revealed by high-speed single-molecule microscopy in live cells

iScience, 2023
Summary: We present a study on the nuclear export efficiency and time of pre-ribosomal subunits in live mammalian cells, using high-speed single-molecule tracking and single-molecule fluorescence resonance energy transfer techniques.
Samuel L. Junod, Mark Tingey, Joseph M. Kelich, Alexander Goryaynov, Karl Herbine, Weidong Yang   +5 more
doaj   +1 more source

Synthetic biology—putting engineering into biology [PDF]

, 2006
Synthetic biology is interpreted as the engineering-driven building of increasingly complex biological entities for novel applications. Encouraged by progress in the design of artificial gene networks, de novo DNA synthesis and protein engineering, we ...
Heinemann, Matthias,, Panke, Sven,
core   +1 more source