Results 11 to 20 of about 7,547 (200)

Septin 9 and phosphoinositides regulate lysosome localization and their association with lipid droplets

iScience, 2022
Summary: The accumulation of lipid droplets (LDs) in the liver is a hallmark of steatosis, which is often associated with lysosomal dysfunction. Nevertheless, the underlying mechanisms remain unclear.
Pei Xuan Song, Juan Peng, Mohyeddine Omrane, Ting ting Cai, Didier Samuel, Ama Gassama-Diagne   +5 more
doaj   +1 more source

Myocardin-related transcription factor and serum response factor regulate cilium turnover by both transcriptional and local mechanisms

iScience, 2021
Summary: Turnover of the primary cilium (PC) is critical for proliferation and tissue homeostasis. Each key component of the PC resorption machinery, the HEF1/Aurora kinase A (AurA)/HDAC6 pathway harbors cis-elements potentially targeted by the ...
Pam Speight, Matthew Rozycki, Shruthi Venugopal, Katalin Szászi, Michael Kofler, András Kapus   +5 more
doaj   +1 more source

Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia

iScience, 2021
Summary: There is evidence that ATM mutated in ataxia-telangiectasia (A-T) plays a key role in protecting against mitochondrial dysfunction, the mechanism for which remains unresolved.
Abrey J. Yeo, Kok L. Chong, Magtouf Gatei, Dongxiu Zou, Romal Stewart, Sarah Withey, Ernst Wolvetang, Robert G. Parton, Adam D. Brown, Michael B. Kastan, David Coman, Martin F. Lavin   +11 more
doaj   +1 more source

Constitutive activation of S1P receptors at the trans-Golgi network is required for surface transport carrier formation

iScience, 2021
Summary: The importance of the G-protein βγ subunits in the regulation of cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PM) is well accepted; however, the molecular mechanism underlying the G-protein activation at the TGN ...
Taro Okada, Susumu Nishida, Lifang Zhang, Nesma Nabil Ibrahim Mohamed, Tianyou Wang, Takeshi Ijuin, Taketoshi Kajimoto, Shun-Ichi Nakamura   +7 more
doaj   +1 more source

Rab33b-exocyst interaction mediates localized secretion for focal adhesion turnover and cell migration

iScience, 2022
Summary: Rab proteins are well known regulators of intracellular trafficking; however, more and more studies point to their function also in other cellular processes, including cell migration.
Synne Arstad Bjørnestad, Noemi Antonella Guadagno, Ingrid Kjos, Cinzia Progida   +3 more
doaj   +1 more source

Identification of embryonic RNA granules that act as sites of mRNA translation after changing their physical properties

iScience, 2022
Summary: Fertilized eggs begin to translate mRNAs at appropriate times and placements to control development, but how the translation is regulated remains unclear.
Keisuke Sato, Moeko Sakai, Anna Ishii, Kaori Maehata, Yuki Takada, Kyota Yasuda, Tomoya Kotani   +6 more
doaj   +1 more source

Temporal and spatial dynamics of immune cells in spontaneous liver transplant tolerance

iScience, 2023
Summary: The liver has long been deemed a tolerogenic organ. We employed high-dimensional mass cytometry and immunohistochemistry to depict the temporal and spatial dynamics of immune cells in the spleen and liver in a murine model of spontaneous liver ...
Weitao Que, Hisashi Ueta, Xin Hu, Miwa Morita-Nakagawa, Masayuki Fujino, Daisuke Ueda, Nobuko Tokuda, Wenxin Huang, Wen-Zhi Guo, Lin Zhong, Xiao-Kang Li   +10 more
doaj   +1 more source

Physical confinement promotes mesenchymal trans-differentiation of invading transformed cells in vivo

iScience, 2022
Summary: Metastasis is tightly linked with poor cancer prognosis, yet it is not clear how transformed cells become invasive carcinomas. We previously discovered that single KRasV12-transformed cells can invade directly from the epithelium by basal cell ...
Teresa Zulueta-Coarasa, John Fadul, Marjana Ahmed, Jody Rosenblatt   +3 more
doaj   +1 more source

Categorization of lung mesenchymal cells in development and fibrosis

iScience, 2021
Summary: Pulmonary mesenchymal cells are critical players in both the mouse and human during lung development and disease states. They are increasingly recognized as highly heterogeneous, but there is no consensus on subpopulations or discriminative ...
Xue Liu, Simon C. Rowan, Jiurong Liang, Changfu Yao, Guanling Huang, Nan Deng, Ting Xie, Di Wu, Yizhou Wang, Ankita Burman, Tanyalak Parimon, Zea Borok, Peter Chen, William C. Parks, Cory M. Hogaboam, S. Samuel Weigt, John Belperio, Barry R. Stripp, Paul W. Noble, Dianhua Jiang   +19 more
doaj   +1 more source

FBP17-mediated finger-like membrane protrusions in cell competition between normal and RasV12-transformed cells

iScience, 2021
Summary: At the initial stage of carcinogenesis, cell competition often occurs between newly emerging transformed cells and the neighboring normal cells, leading to the elimination of transformed cells from the epithelial layer. For instance, when RasV12-
Tomoko Kamasaki, Yumi Miyazaki, Susumu Ishikawa, Kazuya Hoshiba, Keisuke Kuromiya, Nobuyuki Tanimura, Yusuke Mori, Motosuke Tsutsumi, Tomomi Nemoto, Ryota Uehara, Shiro Suetsugu, Toshiki Itoh, Yasuyuki Fujita   +12 more
doaj   +1 more source