Results 31 to 40 of about 37,948 (261)

Examining the impact of managerial support on the performance of healthcare organizations: The mediating role of employee autonomy [PDF]

Srpski Arhiv za Celokupno Lekarstvo
Introduction/Objective. This paper aims to examine the influence of managerial support and employee autonomy on the performance of healthcare organizations.
Trifunović Boban
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Job autonomy and career development satisfaction among healthcare professionals: the moderating role of organizational identification

Frontiers in Psychology
BackgroundUnder China’s Healthy China strategy and the high-quality development agenda for public hospitals, healthcare professionals’ career development satisfaction has become critical for service quality and workforce stability. However, most existing
Yu Xiang, Xueling Guan, Xueling Guan, Ru Meng, Ru Meng, Zhaolin Zhou, Yuxin Qian, Xinru Huang, Xinru Huang   +8 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Ten Successful Years: A Longitudinal Case Study of Autonomy, Control and Learning

Nordic Journal of Working Life Studies, 2017
The article examines three concepts closely related to the Nordic sociotechnical tradition: responsible autonomy, learning, and control. The longitudinal case study analyses the implementation of a 6-hour workday and the development of responsible ...
Heidi Enehaug
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Balancing Organizational Regulation and Agent Autonomy: An MDE-Based Approach [PDF]

, 2009
The deployment of agent societies --as complex systems-- in dynamic and unpredictable settings brings forth critical issues concerning their design. Organizational models have been advocated to specify open systems in dynamic environments in order to accomplish the need to represent regulating structures explicitly and independently from acting ...
Loris Penserini, Virginia Dignum, Athanasios Staikopoulos, Huib Aldewereld, Frank Dignum   +4 more
openaire   +3 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source