Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition [PDF]
, 2016 EZH2 inhibitors have gained great interest for their use as anti-cancer therapeutics. However, most research has focused on EZH2 mutant cancers and recently adverse effects of EZH2 inactivation have come to light.
Martijn Koppens +6 more
openalex +4 more sources
Rapid anticancer drug screening using patient-derived lung cancer organoids: a case report [PDF]
Organoid, 2022 A variety of anticancer drugs and targeted agents for lung cancer have been developed, but some patients do not respond to these medications as intended.
Hyeong Jun Cho +6 more
doaj +1 more source
Technical advances in pluripotent stem cell-derived and tumorigenic organoids [PDF]
Organoid, 2022 Cell culture systems have been widely used to address fundamental questions in biology without sacrificing animals. Three-dimensional (3D) organoids provide more information on in vivo conditions than traditional culture systems because multiple cell ...
Suwon Kang +3 more
doaj +1 more source
A method for culturing patient-derived lung cancer organoids from surgically resected tissues and biopsy samples [PDF]
Organoid, 2022 Background The cancer model system maintaining genetic and phenotypic characteristics of human cancers is crucial for the study of precision cancer medicine.
Yu Ri Ko +4 more
doaj +1 more source
Alveolar organoids: development of an assay to facilitate pulmonary toxicity assessments [PDF]
Organoid, 2022 Background Animal experiments have been performed to predict toxicity in humans in many fields, in-cluding toxicology, medicine, and pharmacology, and have contributed to increasing life ex-pectancy. However, animal testing has been a controversial issue
Jooyeon Lee +7 more
doaj +1 more source
The application of intestinal organoids and their co-culture systems in the study of gastrointestinal diseases [PDF]
Organoid, 2022 The 3-dimensional culture of intestinal organoids provides insights into the phenotype and physiology of the intestine. Intestinal organoids comprise intestinal stem cells and differentiated intestinal epithelial cells; they can be stably cultured over ...
Panida Sittipo, Yun Kyung Lee
doaj +1 more source
Disease modeling and drug screening using human airway organoids: a systematic review [PDF]
Organoid, 2021 Increasing levels of fine environmental dust particles due to industrialization and emerging respiratory illnesses, such as coronavirus disease 2019, pose serious threats to human life.
Do Hyun Kim, Sung Won Kim
doaj +1 more source
Engineered models for studying blood-brain-barrier-associated brain physiology and pathology [PDF]
Organoid, 2021 The blood-brain barrier (BBB) is a transport barrier that suppresses the translocation of potentially harmful substances to the brain tissue. Although the BBB is known to be associated with many kinds of neuropathology, such as neuroinflammation and ...
Hong Nam Kim
doaj +1 more source
A novel method for the isolation of CD45-positive and CD45-negative cells from malignant pleural effusion [PDF]
Organoid, 2021 Background Patient-derived malignant pleural effusion (MPE) samples can be used to identify a patient-specific drug combination since MPE samples are readily available and cost-effective tumor cell sources.
Jimin Choi +5 more
doaj +1 more source
Strategies for vascularization in kidney organoids [PDF]
Organoid, 2022 The establishment of protocols for differentiating kidney organoids from human pluripotent stem cells (hPSCs) has potential for the application of kidney organoids in regenerative medicine. However, the primary obstacle to the regenerative application of
Seo-Yeon Park, Yong Kyun Kim
doaj +1 more source