Building global research equity through lung organoids: a prerequisite for the next respiratory pandemic [PDF]
Frontiers in MedicineMuhammad Kamal Hossain +4 more
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Lung organoids: target cells for understanding respiratory diseases [PDF]
Organoid, 2021 Human respiratory disease research currently lacks in vitro models that recapitulate most of the physiology and architecture of the lung. Furthermore, the complex composition and structure of the lung, as well as anatomical differences between humans and
Jooyeon Lee, Se-Ran Yang
doaj +1 more source
Emerging organoid-based platforms to study salivary gland hypofunction [PDF]
Organoid, 2022 Xerostomia is a pathologic condition of hyposalivation due to salivary gland (SG) dysfunction. Although xerostomia significantly affects the quality of patients’ life, there is no satisfactory treatment for this disease.
Yoojin Seo, Hyung-Sik Kim
doaj +1 more source
Recent advances in liver organoids and their use in modeling of non-alcoholic fatty liver disease [PDF]
Organoid, 2022 The liver is involved in physiological activities critical for survival. Chronic liver disease (CLD) frequently progresses to life-threatening liver failure, as evidenced by CLD patients’ high morbidity and mortality rates.
Kyun Yoo Chi, Jong-Hoon Kim
doaj +1 more source
Fundamental signaling pathways for glioblastoma drug resistance and developing robust organoid models for drug discovery [PDF]
Organoid, 2022 This article presents a review of the current literature on the molecular mechanisms of treatment resistance in glioblastoma. As mounting research continues to explore novel methods of treating glioblastoma, from using organoid models for drug screening ...
Athira Pratap +3 more
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Three-dimensional cardiac organoid formation accelerates the functional maturation of human induced pluripotent stem cell-derived cardiomyocytes [PDF]
Organoid, 2022 Background Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs) offer a promising source for heart disease modeling and drug screening.
Hanbyeol Lee +7 more
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Understanding the cellular pathogenesis of COVID-19 symptoms using organoid technology [PDF]
Organoid, 2022 Patients with coronavirus disease 2019 (COVID-19), which has recently caused a pandemic, have reported symptoms of coronavirus infection that are not well understood by the medical community in general. After severe acute respiratory syndrome coronavirus
Young Hyun Che, Yong Jun Kim
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Development of a protocol for maintaining viability while shipping organoid-derived retinal tissue. [PDF]
, 2020 Retinal organoid technology enables generation of an inexhaustible supply of three-dimensional retinal tissue from human pluripotent stem cells (hPSCs) for regenerative medicine applications.
Binette, Francois +6 more
core +1 more source
Recent advances in multicellular human liver models [PDF]
Organoid, 2022 The liver is the most important metabolic organ in the body. Model systems that recapitulate the complex organ structure and cell composition of the human liver are insufficient to study liver biology and to test toxicity and efficacy during new drug ...
Seon Ju Mun +5 more
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Journal of Orthopaedic Translation, 2022 Background: Bone fracture healing is a postnatal regenerative process in which fibrocartilaginous callus formation and bony callus formation are important. Bony callus formation requires osteoblastic differentiation of MSCs.
Fuxiao Wang +9 more
doaj +1 more source