Results 11 to 20 of about 114,312 (393)

Organoids are not organs: Sources of variation and misinformation in organoid biology [PDF]

Stem Cell Reports, 2023
In the past decade, the term organoid has moved from obscurity to common use to describe a 3D in vitro cellular model of a tissue that recapitulates structural and functional elements of the in vivo organ it models. The term organoid is now applied to structures formed as a result of two distinct processes: the capacity for adult epithelial stem cells ...
Kim Bak Jensen, Melissa Helen Little
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Review on the Vascularization of Organoids and Organoids-on-a-Chip [PDF]

Frontiers in Bioengineering and Biotechnology, 2021
The use of human cells for the construction of 3D organ models in vitro based on cell self-assembly and engineering design has recently increased in popularity in the field of biological science. Although the organoids are able to simulate the structures and functions of organs in vitro, the 3D models have difficulty in forming a complex vascular ...
Xingli Zhao, Zilu Xu, Lang Xiao, Tuo Shi, Haoran Xiao, Yeqin Wang, Yanzhao Li, Fangchao Xue, Wen Zeng, Wen Zeng, Wen Zeng   +10 more
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Organoids and Colorectal Cancer [PDF]

Cancers, 2021
Organoids were first established as a three-dimensional cell culture system from mouse small intestine. Subsequent development has made organoids a key system to study many human physiological and pathological processes that affect a variety of tissues and organs. In particular, organoids are becoming very useful tools to dissect colorectal cancer (CRC)
Alberto Muñoz, Alberto Muñoz, Nuria Rodríguez-Salas, Pilar Bustamante-Madrid, Pilar Bustamante-Madrid, Antonio Barbáchano, A. Fernández-Barral, A. Fernández-Barral, María Jesús Larriba, María Jesús Larriba, Isabel Prieto   +10 more
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Organoids

Nature Reviews Methods Primers, 2022
Organoids have attracted increasing attention because they are simple tissue-engineered cell-based in vitro models that recapitulate many aspects of the complex structure and function of the corresponding in vivo tissue. They can be dissected and interrogated for fundamental mechanistic studies on development, regeneration, and repair in human tissues.
Zixuan Zhao, Xinyi Chen, Anna M. Dowbaj, Aleksandra Sljukic, Kaitlin Bratlie, Luda Lin, Eliza Li Shan Fong, Gowri Manohari Balachander, Zhaowei Chen, Alice Soragni, Meritxell Huch, Yi Arial Zeng, Qun Wang, Hanry Yu   +13 more
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Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish

Frontiers in Science, 2023
Recent advances in human stem cell-derived brain organoids promise to replicate critical molecular and cellular aspects of learning and memory and possibly aspects of cognition in vitro.
Lena Smirnova, B. Caffo, D. Gracias, Qi Huang, I. M. Pantoja, Bohao Tang, D. Zack, C. Berlinicke, J. Boyd, Timothy D. Harris, E. C. Johnson, Brett J. Kagan, Jeffrey Kahn, A. Muotri, B. Paulhamus, J. Schwamborn, Jesse D. Plotkin, Alexander S. Szalay, J. Vogelstein, P. Worley, T. Hartung, Arti Ahluwalia, K. Friston   +22 more
semanticscholar   +1 more source

Small molecule-induced destabilization of β-catenin and RAS is the ideal strategies for suppressing colorectal cancer [PDF]

Organoid, 2023
Background Mutations of adenomatous polyposis coli (APC) and KRAS play essential roles in the development of colorectal cancer (CRC) by forming an abnormal colon morphology.
Yonghyo Kim, Myoung-Hee Kang, Geon-Woo Kim, Yong-Hee Cho   +3 more
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Tumor spheroid-based and microtumor-based vascularized models for replicating the vascularized tumor microenvironment [PDF]

Organoid, 2023
Background Tumor vasculature is a crucial pathway for supplying nutrients and oxygen to tumors during their progression, as well as facilitating the delivery of anticancer drugs or immunotherapeutic agents.
Jiyoung Song, Jihoon Ko, Nakwon Choi, Noo Li Jeon, Hong Nam Kim   +4 more
doaj   +1 more source

Natural biopolymer-based hydrogels as designer matrices for organoid cultures [PDF]

Organoid, 2023
Matrigel, a mouse sarcoma-derived extract, is considered the gold standard for organoid cultures. However, it has several drawbacks, including inconsistent and ill-defined composition, varying quality between batches, and potential cancer-related health ...
Yun Kee Jo
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An Organoid for Woven Bone [PDF]

Advanced Functional Materials, 2020
AbstractBone formation (osteogenesis) is a complex process in which cellular differentiation and the generation of a mineralized organic matrix are synchronized to produce a hybrid hierarchical architecture. To study the mechanisms of osteogenesis in health and disease, there is a great need for functional model systems that capture in parallel both ...
Nico A. J. M. Sommerdijk, Sana Ansari, Wouter H. Nijhuis, Merijn van Erp, Job Fermie, Keita Ito, Nalan Liv, Johanna Melke, Sandra Hofmann, Cilia de Heus, Claudia Muñiz Ortera, Judith Klumperman, Merula Stout, Anat Akiva, Feihu Zhao, Feihu Zhao, Robin van der Meijden   +16 more
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Multimodal spatiotemporal phenotyping of human retinal organoid development

Nature Biotechnology, 2023
Organoids generated from human pluripotent stem cells provide experimental systems to study development and disease, but quantitative measurements across different spatial scales and molecular modalities are lacking.
Philipp Wahle, Giovanna Brancati, Christoph Harmel, Zhisong He, Gabriele Gut, Jacobo Sarabia del Castillo, Aline Xavier da Silveira dos Santos, Qianhui Yu, Pascal Noser, J. S. Fleck, Bruno Gjeta, D. Pavlinić, Simone Picelli, Max Hess, Gregor W. Schmidt, T. Lummen, Yanyan Hou, Patricia Galliker, D. Goldblum, M. Balogh, C. Cowan, H. Scholl, B. Roska, M. Renner, L. Pelkmans, Barbara Treutlein, J. G. Camp   +26 more
semanticscholar   +1 more source