Results 21 to 30 of about 114,312 (393)
Cancer organoid co-culture model system: Novel approach to guide precision medicine
Frontiers in Immunology, 2023 Three-dimensional cancer organoids derived from self-organizing cancer stems are ex vivo miniatures of tumors that faithfully recapitulate their structure, distinctive cancer features, and genetic signatures. As novel tools, current cancer organoids have
Jin Yuan, Xiaoyang Li, Shengji Yu
semanticscholar +1 more source
Cold Spring Harbor Perspectives in Medicine, 2018 Oncogenic Kras are genetic dependencies for the majority of pancreatic and colorectal adenocarcinomas; however, much remains to be understood regarding its tropism to these carcinomas. Recently developed organoid technology presents a more representative model culture system for pancreatic and colon epithelial tissues as well as better fostering the ...
David A. Tuveson, Derek K. Cheng
openaire +3 more sources
Bioreactor Technologies for Enhanced Organoid Culture
International Journal of Molecular Sciences, 2023 An organoid is a 3D organization of cells that can recapitulate some of the structure and function of native tissue. Recent work has seen organoids gain prominence as a valuable model for studying tissue development, drug discovery, and potential ...
Joseph P. Licata +4 more
semanticscholar +1 more source
Lung organoids: target cells for understanding respiratory diseases [PDF]
Organoid, 2021 Human respiratory disease research currently lacks in vitro models that recapitulate most of the physiology and architecture of the lung. Furthermore, the complex composition and structure of the lung, as well as anatomical differences between humans and
Jooyeon Lee, Se-Ran Yang
doaj +1 more source
Development of a protocol for maintaining viability while shipping organoid-derived retinal tissue. [PDF]
, 2020 Retinal organoid technology enables generation of an inexhaustible supply of three-dimensional retinal tissue from human pluripotent stem cells (hPSCs) for regenerative medicine applications.
Binette, Francois +6 more
core +1 more source
Kidney Organoids and Tubuloids [PDF]
Cells, 2020 In the past five years, pluripotent stem cell (PSC)-derived kidney organoids and adult stem or progenitor cell (ASC)-based kidney tubuloids have emerged as advanced in vitro models of kidney development, physiology, and disease. PSC-derived organoids mimic nephrogenesis.
Jitske Jansen +6 more
openaire +6 more sources
Nature Communications, 2023 Induced pluripotent stem cells (iPSCs) are a promising resource for allogeneic cartilage transplantation to treat articular cartilage defects that do not heal spontaneously and often progress to debilitating conditions, such as osteoarthritis.
Kengo Abe +8 more
semanticscholar +1 more source
Emerging organoid-based platforms to study salivary gland hypofunction [PDF]
Organoid, 2022 Xerostomia is a pathologic condition of hyposalivation due to salivary gland (SG) dysfunction. Although xerostomia significantly affects the quality of patients’ life, there is no satisfactory treatment for this disease.
Yoojin Seo, Hyung-Sik Kim
doaj +1 more source
Organoid and Spheroid Tumor Models: Techniques and Applications
Cancers, 2021 Simple Summary Cell cultures can be carried out in three dimensions (3D). Organoids and spheroids are different 3D cell culture models that can be cultured with different techniques.
S. Gunti +3 more
semanticscholar +1 more source
Recent advances in liver organoids and their use in modeling of non-alcoholic fatty liver disease [PDF]
Organoid, 2022 The liver is involved in physiological activities critical for survival. Chronic liver disease (CLD) frequently progresses to life-threatening liver failure, as evidenced by CLD patients’ high morbidity and mortality rates.
Kyun Yoo Chi, Jong-Hoon Kim
doaj +1 more source