Molecules, 2021 Organophosphate hydrolases are promising as potential biotherapeutic agents to treat poisoning with pesticides or nerve gases. However, these enzymes often need to be further engineered in order to become useful in practice.
Alexander Zlobin +3 more
doaj +1 more source
Transcriptional Profiles for Glutamate Transporters Reveal Differences Between Organophosphates but Similarities with Unrelated Neurotoxicants [PDF]
, 2010 The developmental neurotoxicity of organophosphates involves mechanisms other than their shared property as cholinesterase inhibitors, among which are excitotoxicity and oxidative stress.
Lobner, Doug +2 more
core +2 more sources
Hydrolysis of chiral organophosphorus compounds by phosphotriesterases and mammalian paraoxonase-1
Frontiers in Bioscience-Landmark, 2020 Some organophosphorus compounds (OPs), which are used in the manufacturing of insecticides and nerve agents, are racemic mixtures with at least one chiral center with a phosphorus atom.
Antonio Monroy-Noyola +2 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2022 Approximately 30% of the veterans who fought in the 1991 Gulf War (GW) suffer from a disease called Gulf War Illness (GWI), which encompasses a constellation of symptoms including cognitive deficits.
Philip L. Yates +5 more
doaj +1 more source
Pharmacological Blockade of the Calcium Plateau Provides Neuroprotection Following Organophosphate Paraoxon Induced Status Epilepticus in Rats [PDF]
, 2016 Organophosphate (OP) compounds which include nerve agents and pesticides are considered chemical threat agents. Currently approved antidotes are crucial in limiting OP mediated acute mortality.
Ajdacic-Gross +43 more
core +2 more sources
Enzymatic Bioremediation of Organophosphate Compounds—Progress and Remaining Challenges
Frontiers in Bioengineering and Biotechnology, 2019 Organophosphate compounds are ubiquitously employed as agricultural pesticides and maintained as chemical warfare agents by several nations. These compounds are highly toxic, show environmental persistence and accumulation, and contribute to numerous ...
Meghna Thakur +2 more
doaj +1 more source
Colorimetric Detection of Warfare Gases by Polydiacetylenes Toward Equipment‐Free Detection [PDF]
, 2012 Rationally designed polydiacetylene (PDA) molecules have been developed for rapid, selective, sensitive, and convenient colorimetric detection of organophosphate (OP) nerve agents, a mass destruction weapon. Oxime (OX) functionality was incorporated into
Ahn +33 more
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Cyclosarin-An Organophosphate Nerve Agent
Defence Science Journal, 2005 Organophosphorus compounds ascribed to as nerve agents (sarin, soman, tabun, cyclosarin) are highly toxic, and are considered to be the most dangerous chemical compounds. All apparently share a common mechanism of cholinesterase inhibition and can cause similar svmotoms. The . .
G. Krejcova, K. Kuca, L. Sevelova
openaire +1 more source
Organophosphorus Nerve Agents: Types, Toxicity, and Treatments
Journal of Toxicology, 2020 Organophosphorus compounds are extensively used worldwide as pesticides which cause great hazards to human health. Nerve agents, a subcategory of the organophosphorus compounds, have been produced and used during wars, and they have also been used in ...
Sudisha Mukherjee, Rinkoo Devi Gupta
doaj +1 more source
Biosilica-nanogold composite: Easy-to-prepare catalyst for soman degradation [PDF]
, 2019 A very fast single-step biosynthesis of gold nanoparticles (AuNPs) using algal cells of Mallomonas kalinae (MK) is introduced. The average particle size of crystalline AuNPs was approximately 10 nm.
Holišová, Veronika +7 more
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