Results 41 to 50 of about 4,617 (218)

In Vitro Activity of Ebselen and Diphenyl Diselenide Alone and in Combination with Drugs against Trichophyton mentagrophytes Strains

Pharmaceutics, 2022
Background: Dermatophytoses are one of the most prevalent infectious diseases in the world for which the pace of developing new drugs has not kept pace with the observed therapeutic problems.
Sebastian Gnat, Dominik Łagowski, Mariusz Dyląg, Grzegorz Jóźwiak, Aleksandra Trościańczyk, Aneta Nowakiewicz   +5 more
doaj   +1 more source

Synthetic organotelluride compounds induce the reversal of Pdr5p mediated fluconazole resistance in Saccharomyces cerevisiae [PDF]

, 2014
Background: Resistance to fluconazole, a commonly used azole antifungal, is a challenge for the treatment of fungal infections. Resistance can be mediated by overexpression of ABC transporters, which promote drug efflux that requires ATP hydrolysis.
Comasseto, Joao V., Dos Santos, Alcindo A., Ferreira-Pereira, Antonio, Goncalves, Augusto Cesar, Reis de Sa, Leandro Figueira, Sousa, Bruno Artur de, Tessis, Ana Claudia, Toledo, Fabiano Travanca, Wendler, Edison P.   +8 more
core   +3 more sources

Molecular Packing in Crystals of Phenoselenazine [PDF]

, 1976
The crystal structure of phenoselenazine was solved by molecular-packing analysis. Trial models of the rigid molecule were oriented and positioned in the Cheshire cell. The refinement was carried out by structure-factor least-squares calculations using
Conde Amiano, Alejandro, Jiménez Garay, Rafael, Márquez Delgado, Rafael, Villares Durán, María del Pilar   +3 more
core   +1 more source

Reduction of Diphenyl Diselenide and Analogs by Mammalian Thioredoxin Reductase Is Independent of Their Gluthathione Peroxidase-Like Activity: A Possible Novel Pathway for Their Antioxidant Activity

Molecules, 2010
Since the successful use of the organoselenium drug ebselen in clinical trials for the treatment of neuropathological conditions associated with oxidative stress, there have been concerted efforts geared towards understanding the precise mechanism of ...
João Batista Teixeira Rocha, Diego Alves, Lisiane Oliveira Porciúncula, Jéssie Haigert Sudati, Caroline Wagner, Andressa Sausen de Freitas, Alessandro de Souza Prestes, Ige Joseph Kade   +7 more
doaj   +1 more source

Stereoselective Synthesis of Selenium-Containing Glycoconjugates via the Mitsunobu Reaction

Molecules, 2021
A simple and efficient route for the synthesis of new glycoconjugates has been developed. The approach acts as a model for a mini-library of compounds with a deoxy-selenosugar core joined to a polyphenolic moiety with well-known antioxidant properties ...
Luigia Serpico, Mauro De Nisco, Flavio Cermola, Michele Manfra, Silvana Pedatella   +4 more
doaj   +1 more source

The Crystal Structure and Molecular Conformation of 3,7-Dichlorophenoselenazine [PDF]

, 1974
The crystal structure of SeC12NCI2H7 has been solved by Patterson and Fourier methods and refined to an R of 7-5 % by full-matrix least-squares methods.
Bernier, F., Conde Amiano, Alejandro, Márquez Delgado, Rafael   +2 more
core   +2 more sources

Biological importance of organoselenium compounds

Indian Journal of Pharmaceutical Sciences, 2007
Selenium, a nonmetallic element, has structural and enzymatic roles. Selenium influences a number of endocrine processes; selenium supplementation has recently shown some of the important pharmacological intervention, especially in cancer chemoprevention.
MD Karvekar, AK Das, C Narajji
openaire   +1 more source

Mercury and selenium binding biomolecules in terrestrial mammals (Cervus elaphus and Sus scrofa) from a mercury exposed area [PDF]

, 2017
Acknowledgements The authors are grateful to Junta de Comunidades de Castilla-La Mancha (PCC-05-004-2, PAI06-0094, PCI-08-0096, PEII09-0032-5329) and the Ministerio de Economía y Competitividad (CTQ2013-48411-P) for financial support. M.J.
Fariñas, N. Rodríguez, Krupp, E., Martín-Doimeadiosa, R. C. Rodríguez, Matteo, R., Nevado, J. J. Berzas, Ropero, M. J. Patiño   +5 more
core   +1 more source

Thia- and selenaheterocycles by a four-component reaction using elemental sulfur and selenium [PDF]

, 2006
The course of the four-component reactions of (2-benzimidazolyl) acetonitrile, carbondisulfide, isothiocyanate, and sulfur and selenium, respectively, is quite different.
Atanassov, P K, Heimgartner, H, Linden, Anthony   +2 more
core   +1 more source

Antimicrobial Activity of Organoselenium Compounds [PDF]

, 2014
The use of organoselenium reagents as catalysts is a common thread that runs through the chapters of this book, introducing important aspects of the modern organoselenium chemistry: organocatalysis, green chemistry, bioinspiration, antioxidant activity.
  +5 more sources