Results 111 to 120 of about 24,134 (239)
The multiple mechanisms of NR4A2 in neurological disorders and advances in targeted therapy research
Neurobiology of DiseaseNuclear Receptor Subfamily 4 Group A Member 2 (NR4A2) is a transcription factor widely distributed in the central nervous system, playing a crucial regulatory role in various physiological and pathological processes, including dopaminergic neuronal ...
Kexin Duan +8 more
doaj +1 more source
Rapid Communications in Mass Spectrometry, Volume 40, Issue 8, 30 April 2026.ABSTRACT Rationale Estrogen‐related receptor (ERR) agonists such as the drug candidates SLU‐PP‐332 and SLU‐PP‐915 are currently being investigated as exercise mimetics, given their ability to trigger human physiological processes similar to those initiated by actual physical activity.
Tristan Möller +2 more
wiley +1 more source
American Journal of Hematology, Volume 101, Issue 4, Page 718-727, April 2026.ABSTRACT Sickle cell disease (SCD) is a chronic inflammatory state, characterized by increased plasma values of inflammatory and angiogenic proteins. Although red blood cell (RBC) transfusion is known to have immunomodulatory effects in other conditions, its potential effects on the inflammatory state in SCD remain largely unknown.
Lydian A. de Ligt +9 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2012 核受体（nuclear receptor,NR）是一类配体依赖的转录因子,它在生物体内分布广泛、成员众多,是一个大家族。核受体一般可分为四大类:类固醇激素受体、甲状腺激素、维生素D受体及孤儿核受体（orphan nuclear receptors,ONR）[1]。通常,核受体都会含有氨基端（N端）的功能激活结构域、中间的DNA结合结构域以及羧基端（C端）的配体结合结构域 ...
张鹏, 王前, 郑磊
doaj
CRISPR/Cas Genome Editing and Its Applications in Cereal Crop Improvement
Plant-Environment Interactions, Volume 7, Issue 2, April 2026.ABSTRACT CRISPR/Cas‐based genome editing has emerged as a transformative tool for precise genetic improvement of cereal crops. Recent advances in CRISPR technologies, including Cas9, Cas12, Cas13, base editing, and prime editing, have enabled targeted modification of genes and regulatory elements controlling yield, stress tolerance, and grain ...
Sirisha Kaniganti +12 more
wiley +1 more source
Nuclear Receptors: Mechanistic Insights into Endocrine Resistance in Prostate and Breast Cancers
ReceptorsThis review focuses on the pivotal roles of nuclear receptors (NRs) in driving endocrine resistance in prostate and breast cancers. In prostate cancer (PCa), androgen receptor (AR) amplification, mutations, and altered coactivator interactions sustain ...
Macrina Beatriz Silva-Cázares +5 more
doaj +1 more source
Expression and Function Profiling of Orphan Nuclear Receptors using Bacterial Artificial Chromosome (BAC) Transgenesis [PDF]
, 2003 Éric Némoz-Gaillard +2 more
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StabLyzeGraph: High‐throughput screening of combinatorial mutations using graph neural networks
Protein Science, Volume 35, Issue 4, April 2026.Abstract Engineering protein stability is a powerful strategy across biotechnology and medicine, supporting a broad range of applications such as atomic structure determination, discovery of therapeutic molecules, biomanufacturing, diagnostic reagents, industrial biocatalysis, etc.
Muhammad Waqas +5 more
wiley +1 more source
Artificial intelligence streamlines scientific discovery of drug–target interactions
British Journal of Pharmacology, Volume 183, Issue 8, Page 1673-1690, April 2026.Abstract Drug discovery is a complicated process through which new therapeutics are identified to prevent and treat specific diseases. Identification of drug–target interactions (DTIs) stands as a pivotal aspect within the realm of drug discovery and development. The traditional process of drug discovery, especially identification of DTIs, is marked by
Yuxin Yang, Feixiong Cheng
wiley +1 more source
Supplementary Figure S2 from Mapping the FOXA1 Interactome in ER<sup>+</sup> Breast Cancer Cells Using Proximity Labeling Reveals Novel Interactions with the Orphan Nuclear Receptor NR2C2 [PDF]
Rosemary N. Plagens +8 more
openalex +1 more source