Results 11 to 20 of about 24,134 (239)

Orphan nuclear receptor function in the ovary [PDF]

Frontiers in Bioscience, 2007
Orphan nuclear receptors such as germ cell nuclear factor (GCNF), steroidogenic factor 1 (SF-1) and liver receptor homolog-1 (LRH-1), are emerging as important ovarian factors in regulating female reproduction. Within the ovary, GCNF (NR6A1) expression is restricted to the oocyte, while SF-1 (NR5A1) is expressed only in the somatic cells, such as ...
Huajun, Zhao, Zili, Li, Austin J, Cooney, Zi-Jian, Lan   +3 more
openaire   +3 more sources

Minireview: role of orphan nuclear receptors in cancer and potential as drug targets. [PDF]

Mol Endocrinol, 2014
Safe S, Jin UH, Hedrick E, Reeder A, Lee SO.   +4 more
europepmc   +2 more sources

Orphan nuclear receptors [PDF]

Br J Pharmacol, 2009
europepmc   +3 more sources

Nuclear Receptors: Lonesome orphans [PDF]

Current Biology, 1995
Nuclear receptors typically bind to DNA as homodimers or heterodimers, but increasing numbers of orphan receptors have been identified that bind DNA as monomers.
Laudet, Vincent, Adelmant, Guillaume
openaire   +2 more sources

Nuclear Hormone Receptors and Their Ligands: Metabolites in Control of Transcription

Cells, 2020
Nuclear hormone receptors are a family of transcription factors regulated by small molecules derived from the endogenous metabolism or diet. There are forty-eight nuclear hormone receptors in the human genome, twenty of which are still orphans.
Lian Jing Tao, Dong Eun Seo, Benjamin Jackson, Natalia B. Ivanova, Fabio Rinaldo Santori   +4 more
doaj   +1 more source

Small Heterodimer Partner and Innate Immune Regulation [PDF]

Endocrinology and Metabolism, 2016
The nuclear receptor superfamily consists of the steroid and non-steroid hormone receptors and the orphan nuclear receptors. Small heterodimer partner (SHP) is an orphan family nuclear receptor that plays an essential role in the regulation of glucose ...
Jae-Min Yuk, Hyo Sun Jin, Eun-Kyeong Jo
doaj   +1 more source

Identification of an endogenous ligand bound to a native orphan nuclear receptor. [PDF]

PLoS ONE, 2009
Orphan nuclear receptors have been instrumental in identifying novel signaling pathways and therapeutic targets. However, identification of ligands for these receptors has often been based on random compound screens or other biased approaches.
Xiaohui Yuan, Tuong Chi Ta, Min Lin, Jane R Evans, Yinchen Dong, Eugene Bolotin, Mark A Sherman, Barry M Forman, Frances M Sladek   +8 more
doaj   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Estrogen-related receptors alpha, beta and gamma expression and function is associated with transcriptional repressor EZH2 in breast carcinoma

BMC Cancer, 2018
Background Orphan nuclear receptors ERRα, ERRβ and ERRγ that belong to NR3B or type IV nuclear receptor family are well studied for their role in breast cancer pathophysiology.
Kanchan Kumari, Amit K. Adhya, Arabinda Kumar Rath, P. B. Reddy, Sandip K. Mishra   +4 more
doaj   +1 more source

Nuclear Receptors as Autophagy-Based Antimicrobial Therapeutics

Cells, 2020
Autophagy is an intracellular process that targets intracellular pathogens for lysosomal degradation. Autophagy is tightly controlled at transcriptional and post-translational levels.
Prashanta Silwal, Seungwha Paik, Sang Min Jeon, Eun-Kyeong Jo   +3 more
doaj   +1 more source