Results 21 to 30 of about 24,134 (239)
A Review of Melatonin, Its Receptors and Drugs
Eurasian Journal of Medicine, 2019 After a Turkish scientist took Nobel Prize due to his contributions to understand clock genes, melatonin, closely related to these genes, may begin to shine.
Mucahit Emet +5 more
doaj +1 more source
Role of the Orphan Nuclear Receptor NR4A Family in T-Cell Biology
Frontiers in Endocrinology, 2021 The nuclear orphan receptors NR4A1, NR4A2, and NR4A3 are immediate early genes that are induced by various signals. They act as transcription factors and their activity is not regulated by ligand binding and are thus regulated via their expression levels.
Livia Odagiu +7 more
doaj +1 more source
Molecular pharmacokinetic determinants of anticancer kinase inhibitors in humans
Oncology Reviews, 2011 This review presents the published data regarding the molecular determinants (drug metabolizing enzymes, drug transporters and orphan nuclear receptors) of approved anticancer kinase inhibitors pharmacokinetics in humans.
Julie Scholler, Dominique Leveque
doaj +1 more source
PLoS ONE, 2016 Many genes are differentially expressed in the cortex of people with schizophrenia, implicating factors that control transcription more generally. Hormone nuclear receptors dimerize to coordinate context-dependent changes in gene expression.
Susan M Corley +3 more
doaj +1 more source
Antioxidants, 2021 Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor superfamily. Originally described as “orphan nuclear receptors”, they can bind both natural and synthetic ligands acting as agonists or antagonists.
Giuliana Muzio +2 more
doaj +1 more source
Adopted orphans as regulators of inflammation, immunity and skeletal homeostasis
Swiss Medical Weekly, 2014 Adopted orphan nuclear receptors, such as peroxisome proliferator-activated receptors (PPARs) and liver X receptors (LXRs), have emerged as key regulators of inflammation and immunity and likewise control skeletal homeostasis.
Natacha Ipseiz +3 more
doaj +1 more source
Nuclear Receptor RORα/γ: Exciting Modulators in Metabolic Syndrome and Related Disorders
Frontiers in Nutrition, 2022 Under the influences of modern lifestyle, metabolic syndromes (MetS), including insulin resistance, obesity, and fatty liver, featuring a worldwide chronic disease, greatly raise the risk of type 2 diabetes, heart disease, and stroke.
Haotian Gu +8 more
doaj +1 more source
Drosophila motor neuron retraction during metamorphosis is mediated by inputs from TGF-β/BMP signaling and orphan nuclear receptors. [PDF]
PLoS ONE, 2012 Larval motor neurons remodel during Drosophila neuro-muscular junction dismantling at metamorphosis. In this study, we describe the motor neuron retraction as opposed to degeneration based on the early disappearance of β-Spectrin and the continuing ...
Ana Boulanger +4 more
doaj +1 more source
Coactivators for the Orphan Nuclear Receptor RORα [PDF]
Molecular Endocrinology, 1999 A mutation in the nuclear orphan receptor RORalpha results in a severe impairment of cerebellar development by unknown mechanisms. We have shown previously that RORalpha contains a strong constitutive activation domain in its C terminus. We therefore searched for mammalian RORalpha coactivators using the minimal activation domain as bait in a two ...
G B, Atkins +5 more
openaire +2 more sources
Molecules, 2018 Orphan nuclear receptor TLX (NR2E1) plays a critical role in the regulation of neural stem cells (NSC) as well as in the development of NSC-derived brain tumors.
Evgenia Dueva +5 more
doaj +1 more source