Novel Orthopoxvirus and Lethal Disease in Cat, Italy [PDF]
Emerging Infectious Diseases, 2018 We report detection and full-genome characterization of a novel orthopoxvirus (OPXV) responsible for a fatal infection in a cat. The virus induced skin lesions histologically characterized by leukocyte infiltration and eosinophilic cytoplasmic inclusions. Different PCR approaches were unable to assign the virus to a defined OPXV species.
Lanave, Gianvito +10 more
doaj +6 more sources
Emerging Microbes and Infections, 2023 The worldwide outbreak of the monkeypox virus (MPXV) has become a “Public Health Emergency of International Concern” (PHEIC). Severe monkeypox virus infection can be fatal, however, effective therapeutic methods are yet to be developed.
Mengjun Li +21 more
doaj +2 more sources
Ectromelia Virus Infections of Mice as a Model to Support the Licensure of Anti-Orthopoxvirus Therapeutics [PDF]
Viruses, 2010 The absence of herd immunity to orthopoxviruses and the concern that variola or monkeypox viruses could be used for bioterroristic activities has stimulated the development of therapeutics and safer prophylactics.
R. Mark Buller +4 more
doaj +2 more sources
Orthopoxvirus Seroprevalence and Infection Susceptibility in France, Bolivia, Laos, and Mali
Emerging Infectious Diseases, 2022 To determine a demographic overview of orthopoxvirus seroprevalence, we tested blood samples collected during 2003–2019 from France (n = 4,876), Bolivia (n = 601), Laos (n = 657), and Mali (n = 255) for neutralizing antibodies against vaccinia virus. In
Léa Luciani +11 more
doaj +2 more sources
Low prevalence of anti-Orthopoxvirus neutralizing antibodies in an urban population of Brazil [PDF]
Journal of Medical Virology, 2023 Since 1999, Vaccinia virus (VACV) has been described as a causative agent of bovine vaccinia (BV), a zoonotic disease that occurs mainly in rural areas of Brazil.
Galileu Barbosa Costa +8 more
openalex +2 more sources
Orthopoxvirus-specific antibodies wane to undetectable levels 1 year after MVA-BN vaccination of at-risk individuals, the Netherlands, 2022 to 2023. [PDF]
Euro SurveillIn response to the mpox outbreak in 2022 and 2023, widespread vaccination with modified vaccinia Ankara-Bavarian Nordic (MVA-BN, also known as JYNNEOS or Imvanex) was initiated.
van Leeuwen LP +13 more
europepmc +2 more sources
Orthopoxvirus Infections in Rodents, Nigeria, 2018–2019
Emerging Infectious Diseases, 2023 To investigate animal reservoirs of monkeypox virus in Nigeria, we sampled 240 rodents during 2018-2019. Molecular (real-time PCR) and serologic (IgM) evidence indicated orthopoxvirus infections, but presence of monkeypox virus was not confirmed.
Clement Meseko +15 more
openaire +4 more sources
Estimation of anti-orthopoxvirus immunity in Moscow residents and potential risks of spreading Monkeypox virus [PDF]
Frontiers in Immunology, 2022 WHO has declared the outbreak of monkeypox as a public health emergency of international concern. In less than three months, monkeypox was detected in more than 30 000 people and spread to more than 80 countries around the world.
Vladimir А. Gushchin +35 more
openalex +2 more sources
Two noncompeting human neutralizing antibodies targeting MPXV B6 show protective effects against orthopoxvirus infections [PDF]
Nature CommunicationsThe recent outbreak of mpox epidemic, caused by monkeypox virus (MPXV), poses a new threat to global public health. Here, we initially assessed the preexisting antibody level to the MPXV B6 protein in vaccinia vaccinees born before the end of the ...
Runchu Zhao +13 more
openalex +2 more sources
Smallpox, Monkeypox and Other Human Orthopoxvirus Infections
Viruses, 2022 Considering that vaccination against smallpox with live vaccinia virus led to serious adverse effects in some cases, the WHO, after declaration of the global eradication of smallpox in 1980, strongly recommended to discontinue the vaccination in all countries.
Galina A. Shchelkunova +1 more
openaire +4 more sources