An Update of Orthopoxvirus Molecular Evolution [PDF]
Viruses, 2022 Although variola virus (VARV) has been eradicated through widespread vaccination, other orthopoxviruses pathogenic for humans circulate in nature. Recently, new orthopoxviruses, including some able to infect humans, have been found and their complete ...
Igor V. Babkin +2 more
doaj +3 more sources
Orthopoxvirus Genome Evolution: The Role of Gene Loss [PDF]
Viruses, 2010 Poxviruses are highly successful pathogens, known to infect a variety of hosts. The family Poxviridae includes Variola virus, the causative agent of smallpox, which has been eradicated as a public health threat but could potentially reemerge as a ...
Eneida L. Hatcher +3 more
doaj +4 more sources
Serologic evidence of human orthopoxvirus infections in Sierra Leone [PDF]
BMC Research Notes, 2011 Background Orthopoxviruses, including variola virus, vaccinia virus, and monkeypox virus, have previously been documented in humans in West Africa, however, no cases of human orthopoxvirus infection have been reported in the region since 1986.
Goba Augustine +12 more
doaj +4 more sources
Ectromelia Virus Infections of Mice as a Model to Support the Licensure of Anti-Orthopoxvirus Therapeutics [PDF]
Viruses, 2010 The absence of herd immunity to orthopoxviruses and the concern that variola or monkeypox viruses could be used for bioterroristic activities has stimulated the development of therapeutics and safer prophylactics.
Scott Parker +4 more
openalex +3 more sources
Mécanismes d'échappement immunitaire des Orthopoxvirus Orthopoxvirus immune evasion mechanism
Médecine et Maladies Infectieuses, 2004 Frédérique Messud-Petit +1 more
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Estimation of anti-orthopoxvirus immunity in Moscow residents and potential risks of spreading Monkeypox virus [PDF]
Frontiers in Immunology, 2022 WHO has declared the outbreak of monkeypox as a public health emergency of international concern. In less than three months, monkeypox was detected in more than 30 000 people and spread to more than 80 countries around the world.
Vladimir А. Gushchin +35 more
openalex +3 more sources
Skin lesions caused by Orthopoxvirus, cowpox - case report from Poland
Journal of Education, Health and Sport, 2021 Background:Despite the elimination of smallpox, other orthopoxviruses, including cowpox virus, still infect humans. Wild rodents are its natural reservoir.
Konrad Kania +4 more
doaj +1 more source
Evolution of the orthopoxvirus core genome
Virus Research, 2023 Orthopoxviruses comprise several relevant pathogens, including the causative agent of smallpox and monkeypox virus. Analysis of orthopoxvirus genome evolution mainly focused on gene gains/losses. We instead analyzed core genes, which are conserved in all orthopoxviruses.
Molteni, Cristian +5 more
openaire +4 more sources
Therapeutic and Prophylactic Drugs to Treat Orthopoxvirus Infections [PDF]
Future Virology, 2008 With the global eradication of smallpox in 1979, the causative agent, variola, no longer circulates in human populations. Other human poxvirus infections, such as those caused by vaccinia, cowpox virus and molluscum, are usually relatively benign in immunocompetent individuals.
Scott Parker +2 more
openalex +3 more sources
Dynamic Cap-Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease. [PDF]
Adv Sci (Weinh)The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Su H +12 more
europepmc +2 more sources