Results 81 to 90 of about 13,277 (283)
(+)‐Camphor and (−)‐borneol derivatives as potential anti‐orthopoxvirus agents
Archiv der Pharmazie, 2021 Although the World Health Organisation had announced that smallpox was eradicated over 40 years ago, the disease and other related pathogenic poxviruses such as monkeypox remain potential bioterrorist weapons and could also re‐emerge as natural ...
A. Sokolova +9 more
semanticscholar +1 more source
Organoid Models to Study Human Infectious Diseases
Cell Proliferation, EarlyView.Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu +4 more
wiley +1 more source
Conservation and Variation in Orthopoxvirus Genome Structure
Journal of General Virology, 1979 Orthopoxvirus DNA from representative strains of rabbitpox, vaccinia, monkeypox, variola, cowpox and ectromelia viruses was analysed by cleavage with restriction endonucleases HindIII, XhoI or SmaI. Genome mol. wt. vary from about 120 x 10(6) for rabbitpox to about 145 x 10(6) for cowpox.
M. Mackett, L. C. Archard
openaire +3 more sources
medRxivIn the summer of 2022, a large outbreak of Monkeypox virus (MPXV) cases occurred globally. By December 2022, a total of 3,582 Mpox cases had been confirmed within the UK.
B. Hicks +16 more
semanticscholar +1 more source
Primary Human Macrophages Serve as Vehicles for Vaccinia Virus Replication and Dissemination [PDF]
, 2014 Human monocytic and professional antigen-presenting cells have been reported only to exhibit abortive infections with vaccinia virus (VACV). We found that monocyte-derived macrophages (MDMs), including granulocyte macrophage colony-stimulating factor (GM-
Amet, Tohti +7 more
core +1 more source
Viruses, 2021 Orthpoxvirus infection can spread more easily in a population with a waning immunity with the subsequent emergence/re-emergence of the viruses pertaining to this genus.
Francesca Rosone +7 more
semanticscholar +1 more source
Journal of Medical Virology, Volume 97, Issue 9, September 2025.ABSTRACT In the wake of the COVID‐19 pandemic, awareness of emerging pathogens has significantly increased, prompting greater investment in research and preparedness. In this context, arboviral diseases are recognized as unmet medical challenges due to their rapid spread. Notably, the geographical range of several flaviviral diseases is expanding: Zika
Erika Plicanti +11 more
wiley +1 more source
A retrospective study of the orthopoxvirus molecular evolution
Infection, Genetics and Evolution, 2012 The data on the structure of conserved genes of the Old and New World orthopoxviruses and unclassified Yoka poxvirus were used for a Bayesian dating of their independent evolution. This reconstruction estimates the time when an orthopoxvirus ancestor was transferred to the North American continent as approximately 50 thousand years ago (TYA) and allows
Igor V. Babkin +2 more
openaire +3 more sources
Development of ST-246® for Treatment of Poxvirus Infections
Viruses, 2010 ST-246 (Tecovirimat) is a small synthetic antiviral compound being developed to treat pathogenic orthopoxvirus infections of humans. The compound was discovered as part of a high throughput screen designed to identify inhibitors of vaccinia virus-induced
Dennis E. Hruby +3 more
doaj +1 more source
medRxivImmunological memory mediates rapid protection following infection or vaccination including heterologous exposure. However, cross-reactive memory responses in humans remain poorly characterized.
Jameson Crandell +23 more
semanticscholar +1 more source