Results 1 to 10 of about 116 (67)

A model of cell biological signaling predicts a phase transition of signaling and provides mathematical formulae. [PDF]

PLoS ONE, 2014
A biological signal is transmitted by interactions between signaling molecules in the cell. To date, there have been extensive studies regarding signaling pathways using numerical simulation of kinetic equations that are based on equations of continuity ...
Tatsuaki Tsuruyama
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Oscillatory ERK Signaling and Morphology Determine Heterogeneity of Breast Cancer Cell Chemotaxis via MEK-ERK and p38-MAPK Signaling Pathways

Bioengineering, 2023
Chemotaxis, regulated by oscillatory signals, drives critical processes in cancer metastasis. Crucial chemoattractant molecules in breast cancer, CXCL12 and EGF, drive the activation of ERK and Akt.
Kenneth K. Y. Ho, Siddhartha Srivastava, Patrick C. Kinnunen, Krishna Garikipati, Gary D. Luker, Kathryn E. Luker   +5 more
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PLCγ2 controls neutrophil-like cell sensitivity through calcium oscillation and gates chemoattractant concentration range for chemotaxis

Frontiers in Immunology
The relationship between calcium oscillation and cell sensitivity is poorly understood. Calcium oscillation can occur spontaneously or be triggered upon receptor-ligand binding.
Xuehua Xu, Woo Sung Kim, Arthur Lee, Tian Jin   +3 more
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Cholesterol-induced robust Ca oscillation in astrocytes required for survival and lipid droplet formation in high-cholesterol condition

iScience, 2022
Summary: Cholesterol, one of the major cell membrane components, stabilizes membrane fluidity and regulates signal transduction. Beside its canonical roles, cholesterol has been reported to directly activate signaling pathways such as hedgehog (Hh).
Chihiro Adachi, Shio Otsuka, Takafumi Inoue   +2 more
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Substrate stiffness-dependent regulatory volume decrease and calcium signaling in chondrocytes

Acta Biochimica et Biophysica Sinica, 2021
The pericellular matrix stiffness is strongly associated with its biochemical and structural changes during the aging and osteoarthritis progress of articular cartilage.
Zhang Min, Wu Xiaoan, Du Genlai, Chen Weiyi, Zhang Quanyou   +4 more
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Oscillations Governed by the Incoherent Dynamics in Necroptotic Signaling

Frontiers in Physics, 2021
Emerging evidences have suggested that oscillation is important for the induction of cell death. However, whether and how oscillation behavior is involved and required for necroptosis remain elusive.
Fei Xu, Fei Xu, Zhiyong Yin, Ligang Zhu, Jun Jin, Qingzhu He, Qingzhu He, Xiang Li, Xiang Li, Jianwei Shuai, Jianwei Shuai, Jianwei Shuai, Jianwei Shuai   +12 more
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Jag1-Notch cis-interaction determines cell fate segregation in pancreatic development

Nature Communications, 2023
Notch signaling is crucial for pancreatic cell fate choice. With mathematical modeling and experiments, Xu et al. provides new insights into how different Notch ligands and Hes1 oscillation guide the spatial-temporal dynamics of cell differentiation.
Xiaochan Xu, Philip Allan Seymour, Kim Sneppen, Ala Trusina, Anuska la Rosa Egeskov-Madsen, Mette Christine Jørgensen, Mogens Høgh Jensen, Palle Serup   +7 more
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Dynamic intracellular mechanical cues facilitate collective signaling responses

iScience, 2021
Summary: Collective behavior emerges in diverse life machineries, e.g., the immune responses to dynamic stimulations. The essential questions that arise here are that whether and how cells in vivo collectively respond to stimulation frequencies higher ...
Bingchen Che, Wei Zhao, Yanan Liu, Dan Sun, Guangyin Jing, Jintao Bai, Xiqiao Feng, Ce Zhang   +7 more
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Loss of thyroid gland circadian PER2 rhythmicity in aged mice and its potential association with thyroid cancer development

Cell Death and Disease, 2022
Molecular clocks operate in peripheral tissues, including endocrine glands, and play important regulatory roles in this context. However, potential age-related changes in the expression rhythmicity of clock genes and the effects of these changes on the ...
Junguee Lee, Hae Joung Sul, Hyunsu Choi, Dong Hyun Oh, Minho Shong   +4 more
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Computational modeling of the interplay between cadherin-mediated cell adhesion and Wnt signaling pathway. [PDF]

PLoS ONE, 2014
Wnt signaling and cadherin-mediated adhesion have been implicated in both processes of embryonic development and the progression of carcinomas. Recent experimental studies revealed that Wnt signaling and cadherin-mediated cell adhesion have close ...
Jiawen Chen, Zhong-Ru Xie, Yinghao Wu
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