Oscillations and temporal signalling in cells [PDF]
Physical Biology, 2007 The development of new techniques to quantitatively measure gene expression in cells has shed light on a number of systems that display oscillations in protein concentration. Here we review the different mechanisms which can produce oscillations in gene expression or protein concentration, using a framework of simple mathematical models.
G. Tiana +4 more
core +11 more sources
The roles of fission yeast ase1 in mitotic cell division, meiotic nuclear oscillation, and cytokinesis checkpoint signaling. [PDF]
Molecular Biology of the Cell, 2005 The Ase1/Prc1 proteins constitute a conserved microtubule-associated protein family that is implicated in central spindle formation and cytokinesis. Here we characterize a role for fission yeast Ase1. Ase1 localizes to microtubule overlapping zones and displays dynamic alterations of localization during the cell cycle.
A. Yamashita +4 more
semanticscholar +5 more sources
Ca2+ oscillation frequency decoding in cardiac cell hypertrophy: Role of calcineurin/NFAT as Ca2+ signal integrators [PDF]
Proceedings of the National Academy of Sciences, 2008 The role of Ca 2+ signaling in triggering hypertrophy was investigated in neonatal rat cardiomyocytes in vitro . We show that an increase in cell size and sarcomere reorganization were elicited by receptor agonists such as Angiotensin II, aldosterone, and norepinephrine and by a small rise in
M. Colella +5 more
semanticscholar +7 more sources
Heat Oscillations Driven by the Embryonic Cell Cycle Reveal the Energetic Costs of Signaling [PDF]
Developmental Cell, 2019 All living systems function out of equilibrium and exchange energy in the form of heat with their environment. Thus, heat flow can inform on the energetic costs of cellular processes, which are largely unknown. Here, we have repurposed an isothermal calorimeter to measure heat flow between developing zebrafish embryos and the surrounding medium.
Jonathan Rodenfels +2 more
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Oscillations in a cAMP signalling model for cell aggregation – a geometric analysis [PDF]
Journal of Mathematical Analysis and Applications, 2020 Abstract We study a singularly perturbed model for a cyclic adenosine monophosphate (cAMP) signalling system that controls aggregation of the amoeboid microorganism Dictyostelium discoideum. The model, which is based on a classical model due to Martiel and Goldbeter [16] , takes the form of a planar system of ordinary differential equations with two
Miao, Zhouqian +2 more
openaire +4 more sources
A model of cell biological signaling predicts a phase transition of signaling and provides mathematical formulae. [PDF]
PLoS ONE, 2014 A biological signal is transmitted by interactions between signaling molecules in the cell. To date, there have been extensive studies regarding signaling pathways using numerical simulation of kinetic equations that are based on equations of continuity ...
Tatsuaki Tsuruyama
doaj +2 more sources
Cellular Architecture Regulates Collective Calcium Signaling and Cell Contractility.
PLoS Computational Biology, 2016 A key feature of multicellular systems is the ability of cells to function collectively in response to external stimuli. However, the mechanisms of intercellular cell signaling and their functional implications in diverse vascular structures are poorly ...
Jian Sun +4 more
doaj +2 more sources
Frontiers in Cell and Developmental Biology, 2020 This article explores and summarizes recent progress in and the characterization of main players in the regulation and cyclic regeneration of hair follicles.
Patrycja Daszczuk +5 more
doaj +2 more sources
PLCγ2 controls neutrophil-like cell sensitivity through calcium oscillation and gates chemoattractant concentration range for chemotaxis [PDF]
Frontiers in ImmunologyThe relationship between calcium oscillation and cell sensitivity is poorly understood. Calcium oscillation can occur spontaneously or be triggered upon receptor-ligand binding.
Xuehua Xu +3 more
doaj +2 more sources
Visualization of Notch Signaling Oscillation in Cells and Tissues [PDF]
, 2014 The Notch signaling effectors Hes1 and Hes7 exhibit oscillatory expression with a period of about 2-3 h during embryogenesis. Hes1 oscillation is important for proliferation and differentiation of neural stem cells, whereas Hes7 oscillation regulates periodic formation of somites.
Shimojo, Hiromi +2 more
openaire +4 more sources