Cellular Architecture Regulates Collective Calcium Signaling and Cell Contractility.
PLoS Computational Biology, 2016 A key feature of multicellular systems is the ability of cells to function collectively in response to external stimuli. However, the mechanisms of intercellular cell signaling and their functional implications in diverse vascular structures are poorly ...
Jian Sun +4 more
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Frontiers in Cell and Developmental Biology, 2020 This article explores and summarizes recent progress in and the characterization of main players in the regulation and cyclic regeneration of hair follicles.
Patrycja Daszczuk +5 more
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A model of cell biological signaling predicts a phase transition of signaling and provides mathematical formulae. [PDF]
PLoS ONE, 2014 A biological signal is transmitted by interactions between signaling molecules in the cell. To date, there have been extensive studies regarding signaling pathways using numerical simulation of kinetic equations that are based on equations of continuity ...
Tatsuaki Tsuruyama
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The Roles of Fission Yeast Ase1 in Mitotic Cell Division, Meiotic Nuclear Oscillation, and Cytokinesis Checkpoint Signaling [PDF]
Molecular Biology of the Cell, 2005 The Ase1/Prc1 proteins constitute a conserved microtubule-associated protein family that is implicated in central spindle formation and cytokinesis. Here we characterize a role for fission yeast Ase1. Ase1 localizes to microtubule overlapping zones and displays dynamic alterations of localization during the cell cycle.
Akira, Yamashita +4 more
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PLCγ2 controls neutrophil-like cell sensitivity through calcium oscillation and gates chemoattractant concentration range for chemotaxis [PDF]
Frontiers in ImmunologyThe relationship between calcium oscillation and cell sensitivity is poorly understood. Calcium oscillation can occur spontaneously or be triggered upon receptor-ligand binding.
Xuehua Xu +3 more
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Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes. [PDF]
PLoS ONE, 2008 The Kv1.3 potassium channel plays an essential role in effector memory T cells and has been implicated in several important autoimmune diseases including multiple sclerosis, psoriasis and type 1 diabetes.
Yunzhao R Ren +10 more
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A transcriptomic taxonomy of Drosophila circadian neurons around the clock
eLife, 2021 Many different functions are regulated by circadian rhythms, including those orchestrated by discrete clock neurons within animal brains. To comprehensively characterize and assign cell identity to the 75 pairs of Drosophila circadian neurons, we ...
Dingbang Ma +6 more
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An agent-based model of metabolic signaling oscillations in Bacillus subtilis biofilms. [PDF]
PLoS Computational BiologyMicrobes of nearly every species can form biofilms, communities of cells bound together by a self-produced matrix. It is not understood how variation at the cellular level impacts putatively beneficial, colony-level behaviors, such as cell-to-cell ...
Obadiah J Mulder +4 more
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Activation of nuclear Ca2+-dependent gene expression by CRAC channel Ca2+ nanodomains [PDF]
Cell ReportsSummary: Oscillations in the levels of second messengers are observed throughout the phylogenetic tree, with signaling information encoded in the frequency of the spikes.
Yu-Ping Lin +4 more
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Dynamic expression of Notch signaling genes in neural stem/progenitor cells
Frontiers in Neuroscience, 2011 In neural stem/progenitor cells, expression of the Notch effector Hes1, a transcriptional repressor, oscillates with a period of 2-3 hours by negative feedback, and Hes1 oscillations induce the oscillatory expression of the proneural gene Neurogenin2 ...
Hiromi eShimojo +2 more
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