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A model of cell biological signaling predicts a phase transition of signaling and provides mathematical formulae. [PDF]
PLoS ONE, 2014 A biological signal is transmitted by interactions between signaling molecules in the cell. To date, there have been extensive studies regarding signaling pathways using numerical simulation of kinetic equations that are based on equations of continuity ...
Tatsuaki Tsuruyama
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Oscillations in a cAMP signalling model for cell aggregation – a geometric analysis [PDF]
Journal of Mathematical Analysis and Applications, 2020 In this article, the authors perform a geometric analysis of a singularly perturbed model for a cyclic adenosine monophosphate (cAMP) signalling system that controls aggregation of the amoeboid microorganism \textit{Dictyostelium discoideum} and which can be rewritten into the form of a planar system of ordinary differential equations with two small ...
Miao, Zhouqian +2 more
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iScience, 2022 Summary: Cholesterol, one of the major cell membrane components, stabilizes membrane fluidity and regulates signal transduction. Beside its canonical roles, cholesterol has been reported to directly activate signaling pathways such as hedgehog (Hh).
Chihiro Adachi +2 more
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Substrate stiffness-dependent regulatory volume decrease and calcium signaling in chondrocytes
Acta Biochimica et Biophysica Sinica, 2021 The pericellular matrix stiffness is strongly associated with its biochemical and structural changes during the aging and osteoarthritis progress of articular cartilage.
Zhang Min +4 more
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Oscillations and temporal signalling in cells [PDF]
Physical Biology, 2007 The development of new techniques to quantitatively measure gene expression in cells has shed light on a number of systems that display oscillations in protein concentration. Here we review the different mechanisms which can produce oscillations in gene expression or protein concentration, using a framework of simple mathematical models.
G. Tiana +4 more
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Oscillations Governed by the Incoherent Dynamics in Necroptotic Signaling
Frontiers in Physics, 2021 Emerging evidences have suggested that oscillation is important for the induction of cell death. However, whether and how oscillation behavior is involved and required for necroptosis remain elusive.
Fei Xu +12 more
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Jag1-Notch cis-interaction determines cell fate segregation in pancreatic development
Nature Communications, 2023 Notch signaling is crucial for pancreatic cell fate choice. With mathematical modeling and experiments, Xu et al. provides new insights into how different Notch ligands and Hes1 oscillation guide the spatial-temporal dynamics of cell differentiation.
Xiaochan Xu +7 more
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Dynamic intracellular mechanical cues facilitate collective signaling responses
iScience, 2021 Summary: Collective behavior emerges in diverse life machineries, e.g., the immune responses to dynamic stimulations. The essential questions that arise here are that whether and how cells in vivo collectively respond to stimulation frequencies higher ...
Bingchen Che +7 more
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Cell Death and Disease, 2022 Molecular clocks operate in peripheral tissues, including endocrine glands, and play important regulatory roles in this context. However, potential age-related changes in the expression rhythmicity of clock genes and the effects of these changes on the ...
Junguee Lee +4 more
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Purinergic signalling is required for calcium oscillations in migratory chondrogenic progenitor cells [PDF]
Pflügers Archiv - European Journal of Physiology, 2014 Osteoarthritis (OA) is the most common form of chronic musculoskeletal disorders. A migratory stem cell population termed chondrogenic progenitor cells (CPC) with in vitro chondrogenic potential was previously isolated from OA cartilage. Since intracellular Ca(2+) signalling is an important regulator of chondrogenesis, we aimed to provide a detailed ...
Matta, C +8 more
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