Results 1 to 10 of about 23,152 (261)
PLCγ2 controls neutrophil-like cell sensitivity through calcium oscillation and gates chemoattractant concentration range for chemotaxis [PDF]
Frontiers in ImmunologyThe relationship between calcium oscillation and cell sensitivity is poorly understood. Calcium oscillation can occur spontaneously or be triggered upon receptor-ligand binding.
Xuehua Xu +3 more
doaj +4 more sources
A model of cell biological signaling predicts a phase transition of signaling and provides mathematical formulae. [PDF]
PLoS ONE, 2014 A biological signal is transmitted by interactions between signaling molecules in the cell. To date, there have been extensive studies regarding signaling pathways using numerical simulation of kinetic equations that are based on equations of continuity ...
Tatsuaki Tsuruyama
doaj +3 more sources
Bioengineering, 2023 Chemotaxis, regulated by oscillatory signals, drives critical processes in cancer metastasis. Crucial chemoattractant molecules in breast cancer, CXCL12 and EGF, drive the activation of ERK and Akt.
Kenneth K. Y. Ho +5 more
doaj +3 more sources
An agent-based model of metabolic signaling oscillations in Bacillus subtilis biofilms. [PDF]
PLoS Computational BiologyMicrobes of nearly every species can form biofilms, communities of cells bound together by a self-produced matrix. It is not understood how variation at the cellular level impacts putatively beneficial, colony-level behaviors, such as cell-to-cell ...
Obadiah J Mulder +4 more
doaj +2 more sources
The Roles of Fission Yeast Ase1 in Mitotic Cell Division, Meiotic Nuclear Oscillation, and Cytokinesis Checkpoint Signaling [PDF]
Molecular Biology of the Cell, 2005 The Ase1/Prc1 proteins constitute a conserved microtubule-associated protein family that is implicated in central spindle formation and cytokinesis. Here we characterize a role for fission yeast Ase1. Ase1 localizes to microtubule overlapping zones and displays dynamic alterations of localization during the cell cycle.
Takashi Toda, Masamitsu Sato
exaly +3 more sources
Oscillations in a cAMP signalling model for cell aggregation – a geometric analysis [PDF]
Journal of Mathematical Analysis and Applications, 2020 In this article, the authors perform a geometric analysis of a singularly perturbed model for a cyclic adenosine monophosphate (cAMP) signalling system that controls aggregation of the amoeboid microorganism \textit{Dictyostelium discoideum} and which can be rewritten into the form of a planar system of ordinary differential equations with two small ...
Miao, Zhouqian +2 more
openaire +3 more sources
iScience, 2022 Summary: Cholesterol, one of the major cell membrane components, stabilizes membrane fluidity and regulates signal transduction. Beside its canonical roles, cholesterol has been reported to directly activate signaling pathways such as hedgehog (Hh).
Chihiro Adachi +2 more
doaj +1 more source
Substrate stiffness-dependent regulatory volume decrease and calcium signaling in chondrocytes
Acta Biochimica et Biophysica Sinica, 2021 The pericellular matrix stiffness is strongly associated with its biochemical and structural changes during the aging and osteoarthritis progress of articular cartilage.
Zhang Min +4 more
doaj +1 more source
Oscillations and temporal signalling in cells [PDF]
Physical Biology, 2007 The development of new techniques to quantitatively measure gene expression in cells has shed light on a number of systems that display oscillations in protein concentration. Here we review the different mechanisms which can produce oscillations in gene expression or protein concentration, using a framework of simple mathematical models.
G. Tiana +4 more
openaire +5 more sources
Oscillations Governed by the Incoherent Dynamics in Necroptotic Signaling
Frontiers in Physics, 2021 Emerging evidences have suggested that oscillation is important for the induction of cell death. However, whether and how oscillation behavior is involved and required for necroptosis remain elusive.
Fei Xu +12 more
doaj +1 more source