Results 1 to 10 of about 52,778 (298)

PLCγ2 controls neutrophil-like cell sensitivity through calcium oscillation and gates chemoattractant concentration range for chemotaxis [PDF]

Frontiers in Immunology
The relationship between calcium oscillation and cell sensitivity is poorly understood. Calcium oscillation can occur spontaneously or be triggered upon receptor-ligand binding.
Xuehua Xu, Woo Sung Kim, Arthur Lee, Tian Jin   +3 more
doaj   +2 more sources

An agent-based model of metabolic signaling oscillations in Bacillus subtilis biofilms. [PDF]

PLoS Computational Biology
Microbes of nearly every species can form biofilms, communities of cells bound together by a self-produced matrix. It is not understood how variation at the cellular level impacts putatively beneficial, colony-level behaviors, such as cell-to-cell ...
Obadiah J Mulder, Maya Peters Kostman, Abdulrahmen Almodaimegh, Michael D Edge, Joseph W Larkin   +4 more
doaj   +2 more sources

Calcium oscillations in mesenchymal stem cells, a control on cell cycle progression to influence cell fate towards proliferation or differentiation? [PDF]

Stem Cell Research & Therapy
Background Under regular culture conditions, mesenchymal stem cells (MSCs) exhibit cytosolic calcium concentration oscillations (Ca2+ oscillations), that change, especially in frequency, after the differentiation of the MSCs.
Leslie A. Vallet, Marina Sánchez-Petidier, Romain Fernandes, Nataliia Naumova, Caterina Merla, Claudia Consales, Giorgia Innamorati, Franck M. André, Lluis M. Mir   +8 more
doaj   +2 more sources

Immediate nuclear accumulation of BMAL1 to regulate cellular circadian clock synchronization [PDF]

Communications Biology
Cell-autonomous circadian clocks coordinate daily physiological timing, allowing them to synchronize with the environment. However, the initial signaling events shared by diverse synchronizing cues remain elusive.
Teruya Tamaru, Genki Kawamura, Hikari Yoshitane, Satoshi Koinuma, Yoshitaka Fukada, Atsuhiko Naito, Takeaki Ozawa, Ken Takamatsu   +7 more
doaj   +2 more sources

Cholesterol-induced robust Ca oscillation in astrocytes required for survival and lipid droplet formation in high-cholesterol condition

iScience, 2022
Summary: Cholesterol, one of the major cell membrane components, stabilizes membrane fluidity and regulates signal transduction. Beside its canonical roles, cholesterol has been reported to directly activate signaling pathways such as hedgehog (Hh).
Chihiro Adachi, Shio Otsuka, Takafumi Inoue   +2 more
doaj   +1 more source

Substrate stiffness-dependent regulatory volume decrease and calcium signaling in chondrocytes

Acta Biochimica et Biophysica Sinica, 2021
The pericellular matrix stiffness is strongly associated with its biochemical and structural changes during the aging and osteoarthritis progress of articular cartilage.
Zhang Min, Wu Xiaoan, Du Genlai, Chen Weiyi, Zhang Quanyou   +4 more
doaj   +1 more source

Oscillations in a cAMP signalling model for cell aggregation – a geometric analysis [PDF]

Journal of Mathematical Analysis and Applications, 2020
In this article, the authors perform a geometric analysis of a singularly perturbed model for a cyclic adenosine monophosphate (cAMP) signalling system that controls aggregation of the amoeboid microorganism \textit{Dictyostelium discoideum} and which can be rewritten into the form of a planar system of ordinary differential equations with two small ...
Miao, Zhouqian, Popovic, Nikola, Szmolyan, Peter   +2 more
openaire   +3 more sources

Oscillations and temporal signalling in cells [PDF]

Physical Biology, 2007
The development of new techniques to quantitatively measure gene expression in cells has shed light on a number of systems that display oscillations in protein concentration. Here we review the different mechanisms which can produce oscillations in gene expression or protein concentration, using a framework of simple mathematical models.
G. Tiana, S. Krishna, S. Pigolotti, M. H. Jensen, K. Sneppen   +4 more
openaire   +5 more sources

Oscillations Governed by the Incoherent Dynamics in Necroptotic Signaling

Frontiers in Physics, 2021
Emerging evidences have suggested that oscillation is important for the induction of cell death. However, whether and how oscillation behavior is involved and required for necroptosis remain elusive.
Fei Xu, Fei Xu, Zhiyong Yin, Ligang Zhu, Jun Jin, Qingzhu He, Qingzhu He, Xiang Li, Xiang Li, Jianwei Shuai, Jianwei Shuai, Jianwei Shuai, Jianwei Shuai   +12 more
doaj   +1 more source

Jag1-Notch cis-interaction determines cell fate segregation in pancreatic development

Nature Communications, 2023
Notch signaling is crucial for pancreatic cell fate choice. With mathematical modeling and experiments, Xu et al. provides new insights into how different Notch ligands and Hes1 oscillation guide the spatial-temporal dynamics of cell differentiation.
Xiaochan Xu, Philip Allan Seymour, Kim Sneppen, Ala Trusina, Anuska la Rosa Egeskov-Madsen, Mette Christine Jørgensen, Mogens Høgh Jensen, Palle Serup   +7 more
doaj   +1 more source