Clock-modified mesenchymal stromal cells therapy rescues molecular circadian oscillation and age-related bone loss via miR142-3p/Bmal1/YAP signaling axis [PDF]
Cell Death Discovery, 2022 Age-related bone loss and disease strongly affect the quality of life of the elderly population. Cellular circadian rhythms have been reported to regulate bone aging, and micro RNAs (miRNAs) play crucial posttranscriptional regulatory roles in the ...
Sa Cha +5 more
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A model of cell biological signaling predicts a phase transition of signaling and provides mathematical formulae. [PDF]
PLoS ONE, 2014 A biological signal is transmitted by interactions between signaling molecules in the cell. To date, there have been extensive studies regarding signaling pathways using numerical simulation of kinetic equations that are based on equations of continuity ...
Tatsuaki Tsuruyama
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Cellular Architecture Regulates Collective Calcium Signaling and Cell Contractility.
PLoS Computational Biology, 2016 A key feature of multicellular systems is the ability of cells to function collectively in response to external stimuli. However, the mechanisms of intercellular cell signaling and their functional implications in diverse vascular structures are poorly ...
Jian Sun +4 more
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Frontiers in Cell and Developmental Biology, 2020 This article explores and summarizes recent progress in and the characterization of main players in the regulation and cyclic regeneration of hair follicles.
Patrycja Daszczuk +5 more
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PLCγ2 controls neutrophil-like cell sensitivity through calcium oscillation and gates chemoattractant concentration range for chemotaxis [PDF]
Frontiers in ImmunologyThe relationship between calcium oscillation and cell sensitivity is poorly understood. Calcium oscillation can occur spontaneously or be triggered upon receptor-ligand binding.
Xuehua Xu +3 more
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Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes. [PDF]
PLoS ONE, 2008 The Kv1.3 potassium channel plays an essential role in effector memory T cells and has been implicated in several important autoimmune diseases including multiple sclerosis, psoriasis and type 1 diabetes.
Yunzhao R Ren +10 more
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A transcriptomic taxonomy of Drosophila circadian neurons around the clock
eLife, 2021 Many different functions are regulated by circadian rhythms, including those orchestrated by discrete clock neurons within animal brains. To comprehensively characterize and assign cell identity to the 75 pairs of Drosophila circadian neurons, we ...
Dingbang Ma +6 more
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Oscillations and temporal signalling in cells [PDF]
, 2007 The development of new techniques to quantitatively measure gene expression in cells has shed light on a number of systems that display oscillations in protein concentration.
G. Tiana +9 more
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Dynamic expression of Notch signaling genes in neural stem/progenitor cells
Frontiers in Neuroscience, 2011 In neural stem/progenitor cells, expression of the Notch effector Hes1, a transcriptional repressor, oscillates with a period of 2-3 hours by negative feedback, and Hes1 oscillations induce the oscillatory expression of the proneural gene Neurogenin2 ...
Hiromi eShimojo +2 more
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Computer identification of Notch3 in the neurogenic progenitor cells of mammalian early optic vesicles [PDF]
BMC Research NotesObjective The developing mammalian retina initially contains undifferentiated cells, providing a model for investigating the mechanisms of differentiation.
Yoshitoku Watabe +3 more
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