Clock-modified mesenchymal stromal cells therapy rescues molecular circadian oscillation and age-related bone loss via miR142-3p/Bmal1/YAP signaling axis [PDF]
Cell Death Discovery, 2022 Age-related bone loss and disease strongly affect the quality of life of the elderly population. Cellular circadian rhythms have been reported to regulate bone aging, and micro RNAs (miRNAs) play crucial posttranscriptional regulatory roles in the ...
Sa Cha +5 more
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PLCγ2 controls neutrophil-like cell sensitivity through calcium oscillation and gates chemoattractant concentration range for chemotaxis [PDF]
Frontiers in ImmunologyThe relationship between calcium oscillation and cell sensitivity is poorly understood. Calcium oscillation can occur spontaneously or be triggered upon receptor-ligand binding.
Xuehua Xu +3 more
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Computer identification of Notch3 in the neurogenic progenitor cells of mammalian early optic vesicles [PDF]
BMC Research NotesObjective The developing mammalian retina initially contains undifferentiated cells, providing a model for investigating the mechanisms of differentiation.
Yoshitoku Watabe +3 more
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Calcium oscillations in mesenchymal stem cells, a control on cell cycle progression to influence cell fate towards proliferation or differentiation? [PDF]
Stem Cell Research & TherapyBackground Under regular culture conditions, mesenchymal stem cells (MSCs) exhibit cytosolic calcium concentration oscillations (Ca2+ oscillations), that change, especially in frequency, after the differentiation of the MSCs.
Leslie A. Vallet +8 more
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Remodeling of calcium signaling and store operated calcium entry as a consequence of human neural progenitor cell differentiation [PDF]
Scientific ReportsThe differentiation of neural progenitor cells into glial and neuronal lineages is a fundamental process in neurodevelopment. This complex process is tightly regulated by several signaling pathways, including calcium signaling. Calcium signaling not only
Silke B. Chalmers +4 more
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Origins of Ultrasensitivity and Complex Signaling Dynamics of Cellular Hydrogen Peroxide and Peroxiredoxin [PDF]
AntioxidantsHydrogen peroxide (H2O2) plays a crucial role in cell signaling in response to physiological and environmental perturbations. H2O2 can oxidize typical 2-Cys peroxiredoxin (PRX) first into a sulfenic acid, which resolves into a disulfide that can be ...
Shengnan Liu, Jingbo Pi, Qiang Zhang
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iScience, 2022 Summary: Cholesterol, one of the major cell membrane components, stabilizes membrane fluidity and regulates signal transduction. Beside its canonical roles, cholesterol has been reported to directly activate signaling pathways such as hedgehog (Hh).
Chihiro Adachi +2 more
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Substrate stiffness-dependent regulatory volume decrease and calcium signaling in chondrocytes
Acta Biochimica et Biophysica Sinica, 2021 The pericellular matrix stiffness is strongly associated with its biochemical and structural changes during the aging and osteoarthritis progress of articular cartilage.
Zhang Min +4 more
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Oscillations Governed by the Incoherent Dynamics in Necroptotic Signaling
Frontiers in Physics, 2021 Emerging evidences have suggested that oscillation is important for the induction of cell death. However, whether and how oscillation behavior is involved and required for necroptosis remain elusive.
Fei Xu +12 more
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Dynamic intracellular mechanical cues facilitate collective signaling responses
iScience, 2021 Summary: Collective behavior emerges in diverse life machineries, e.g., the immune responses to dynamic stimulations. The essential questions that arise here are that whether and how cells in vivo collectively respond to stimulation frequencies higher ...
Bingchen Che +7 more
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