Oscillations and temporal signalling in cells [PDF]
Physical Biology, 2007 The development of new techniques to quantitatively measure gene expression in cells has shed light on a number of systems that display oscillations in protein concentration. Here we review the different mechanisms which can produce oscillations in gene expression or protein concentration, using a framework of simple mathematical models.
Jensen, M. H. +4 more
arxiv +13 more sources
Heat Oscillations Driven by the Embryonic Cell Cycle Reveal the Energetic Costs of Signaling [PDF]
Developmental Cell, 2020 All living systems function out of equilibrium and exchange energy in the form of heat with their environment. Thus, heat flow can inform on the energetic costs of cellular processes, which are largely unknown. Here, we have repurposed an isothermal calorimeter to measure heat flow between developing zebrafish embryos and the surrounding medium.
Jonathan Rodenfels +2 more
openalex +6 more sources
Oscillations in a cAMP signalling model for cell aggregation – a geometric analysis [PDF]
Journal of Mathematical Analysis and Applications, 2019 Abstract We study a singularly perturbed model for a cyclic adenosine monophosphate (cAMP) signalling system that controls aggregation of the amoeboid microorganism Dictyostelium discoideum. The model, which is based on a classical model due to Martiel and Goldbeter [16] , takes the form of a planar system of ordinary differential equations with two
Zhouqian Miao +2 more
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Visualization of Notch Signaling Oscillation in Cells and Tissues [PDF]
, 2014 The Notch signaling effectors Hes1 and Hes7 exhibit oscillatory expression with a period of about 2-3 h during embryogenesis. Hes1 oscillation is important for proliferation and differentiation of neural stem cells, whereas Hes7 oscillation regulates periodic formation of somites.
Hiromi Shimojo +2 more
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Signaling Pathways Underlying Muscarinic Receptor-induced [Ca2+] Oscillations in HEK293 Cells [PDF]
Journal of Biological Chemistry, 2001 We have investigated the signaling pathways underlying muscarinic receptor-induced calcium oscillations in human embryonic kidney (HEK293) cells. Activation of muscarinic receptors with a maximal concentration of carbachol (100 microm) induced a biphasic rise in cytoplasmic calcium ([Ca2+]i) comprised of release of Ca2+ from intracellular stores and ...
Dali Luo +3 more
openalex +5 more sources
Clock-modified mesenchymal stromal cells therapy rescues molecular circadian oscillation and age-related bone loss via miR142-3p/Bmal1/YAP signaling axis [PDF]
Cell Death Discovery, 2022 Age-related bone loss and disease strongly affect the quality of life of the elderly population. Cellular circadian rhythms have been reported to regulate bone aging, and micro RNAs (miRNAs) play crucial posttranscriptional regulatory roles in the ...
Sa Cha +5 more
doaj +2 more sources
Autonomous Ca2+ Oscillations Reflect Oncogenic Signaling in B-ALL Cells
Blood, 2019 Background: Engagement of the B-cell receptor (BCR) results in Ca2+ flux and is linked to B-cell survival based on store-operated Ca2+ entry (SOCE), which is triggered by ORAI1 and stromal interaction molecule-1 (STIM1). While normal B-cells release Ca2+ only in response to external stimuli (e.g. BCR-engagement), we recently observed that transformed B-
Kohei Kume +3 more
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IGF-I concentration determines cell fate by converting signaling dynamics as a bifurcation parameter in L6 myoblasts [PDF]
Scientific ReportsInsulin-like growth factor (IGF)-I mediates long-term activities that determine cell fate, including cell proliferation and differentiation. This study aimed to characterize the mechanisms by which IGF-I determines cell fate from the aspect of IGF-I ...
Ryosuke Okino +10 more
doaj +2 more sources
The Roles of Fission Yeast Ase1 in Mitotic Cell Division, Meiotic Nuclear Oscillation, and Cytokinesis Checkpoint Signaling [PDF]
Molecular Biology of the Cell, 2005 The Ase1/Prc1 proteins constitute a conserved microtubule-associated protein family that is implicated in central spindle formation and cytokinesis. Here we characterize a role for fission yeast Ase1. Ase1 localizes to microtubule overlapping zones and displays dynamic alterations of localization during the cell cycle.
Akira Yamashita +4 more
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Role of Regulator of G Protein Signaling 2 (RGS2) in Ca2+ Oscillations and Adaptation of Ca2+ Signaling to Reduce Excitability of RGS2–/– Cells [PDF]
Journal of Biological Chemistry, 2004 Regulators of G protein signaling (RGS) proteins accelerate the GTPase activity of Galpha subunits to determine the duration of the stimulated state and control G protein-coupled receptor-mediated cell signaling. RGS2 is an RGS protein that shows preference toward Galpha(q).
Xinhua Wang +4 more
openalex +4 more sources