Results 1 to 10 of about 23,870 (115)

GABA Regulates Ca²⁺ Oscillations and Synchronization in Pancreatic Beta Cells [PDF]

Metabolites
Background/Objectives: Gamma-aminobutyric acid (GABA) is increasingly recognized as an important modulator of pancreatic beta-cell function, but the mechanisms by which it regulates intracellular Ca2+ oscillations and coordinated beta-cell activity ...
Vladimir Grubelnik, Marko Marhl
doaj   +2 more sources

Oscillatory ERK Signaling and Morphology Determine Heterogeneity of Breast Cancer Cell Chemotaxis via MEK-ERK and p38-MAPK Signaling Pathways

Bioengineering, 2023
Chemotaxis, regulated by oscillatory signals, drives critical processes in cancer metastasis. Crucial chemoattractant molecules in breast cancer, CXCL12 and EGF, drive the activation of ERK and Akt.
Kenneth K. Y. Ho, Siddhartha Srivastava, Patrick C. Kinnunen, Krishna Garikipati, Gary D. Luker, Kathryn E. Luker   +5 more
doaj   +3 more sources

A model of cell biological signaling predicts a phase transition of signaling and provides mathematical formulae. [PDF]

PLoS ONE, 2014
A biological signal is transmitted by interactions between signaling molecules in the cell. To date, there have been extensive studies regarding signaling pathways using numerical simulation of kinetic equations that are based on equations of continuity ...
Tatsuaki Tsuruyama
doaj   +3 more sources

PLCγ2 controls neutrophil-like cell sensitivity through calcium oscillation and gates chemoattractant concentration range for chemotaxis

Frontiers in Immunology
The relationship between calcium oscillation and cell sensitivity is poorly understood. Calcium oscillation can occur spontaneously or be triggered upon receptor-ligand binding.
Xuehua Xu, Woo Sung Kim, Arthur Lee, Tian Jin   +3 more
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An agent-based model of metabolic signaling oscillations in Bacillus subtilis biofilms. [PDF]

PLoS Computational Biology
Microbes of nearly every species can form biofilms, communities of cells bound together by a self-produced matrix. It is not understood how variation at the cellular level impacts putatively beneficial, colony-level behaviors, such as cell-to-cell ...
Obadiah J Mulder, Maya Peters Kostman, Abdulrahmen Almodaimegh, Michael D Edge, Joseph W Larkin   +4 more
doaj   +2 more sources

Cholesterol-induced robust Ca oscillation in astrocytes required for survival and lipid droplet formation in high-cholesterol condition

iScience, 2022
Summary: Cholesterol, one of the major cell membrane components, stabilizes membrane fluidity and regulates signal transduction. Beside its canonical roles, cholesterol has been reported to directly activate signaling pathways such as hedgehog (Hh).
Chihiro Adachi, Shio Otsuka, Takafumi Inoue   +2 more
doaj   +1 more source

Substrate stiffness-dependent regulatory volume decrease and calcium signaling in chondrocytes

Acta Biochimica et Biophysica Sinica, 2021
The pericellular matrix stiffness is strongly associated with its biochemical and structural changes during the aging and osteoarthritis progress of articular cartilage.
Zhang Min, Wu Xiaoan, Du Genlai, Chen Weiyi, Zhang Quanyou   +4 more
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Oscillations Governed by the Incoherent Dynamics in Necroptotic Signaling

Frontiers in Physics, 2021
Emerging evidences have suggested that oscillation is important for the induction of cell death. However, whether and how oscillation behavior is involved and required for necroptosis remain elusive.
Fei Xu, Fei Xu, Zhiyong Yin, Ligang Zhu, Jun Jin, Qingzhu He, Qingzhu He, Xiang Li, Xiang Li, Jianwei Shuai, Jianwei Shuai, Jianwei Shuai, Jianwei Shuai   +12 more
doaj   +1 more source

Jag1-Notch cis-interaction determines cell fate segregation in pancreatic development

Nature Communications, 2023
Notch signaling is crucial for pancreatic cell fate choice. With mathematical modeling and experiments, Xu et al. provides new insights into how different Notch ligands and Hes1 oscillation guide the spatial-temporal dynamics of cell differentiation.
Xiaochan Xu, Philip Allan Seymour, Kim Sneppen, Ala Trusina, Anuska la Rosa Egeskov-Madsen, Mette Christine Jørgensen, Mogens Høgh Jensen, Palle Serup   +7 more
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Dynamic intracellular mechanical cues facilitate collective signaling responses

iScience, 2021
Summary: Collective behavior emerges in diverse life machineries, e.g., the immune responses to dynamic stimulations. The essential questions that arise here are that whether and how cells in vivo collectively respond to stimulation frequencies higher ...
Bingchen Che, Wei Zhao, Yanan Liu, Dan Sun, Guangyin Jing, Jintao Bai, Xiqiao Feng, Ce Zhang   +7 more
doaj   +1 more source