Motile Hair Cells Distinguish Mechanical Signals from Noise Best When They Operate on the Brink of Spontaneous Oscillation [PDF]
Biophysical Journal, 2018 Dáibhid Ó Maoiléidigh +2 more
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A model of cell biological signaling predicts a phase transition of signaling and provides mathematical formulae. [PDF]
PLoS ONE, 2014 A biological signal is transmitted by interactions between signaling molecules in the cell. To date, there have been extensive studies regarding signaling pathways using numerical simulation of kinetic equations that are based on equations of continuity ...
Tatsuaki Tsuruyama
doaj +1 more source
Computational modeling of the interplay between cadherin-mediated cell adhesion and Wnt signaling pathway. [PDF]
PLoS ONE, 2014 Wnt signaling and cadherin-mediated adhesion have been implicated in both processes of embryonic development and the progression of carcinomas. Recent experimental studies revealed that Wnt signaling and cadherin-mediated cell adhesion have close ...
Jiawen Chen, Zhong-Ru Xie, Yinghao Wu
doaj +1 more source
Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes. [PDF]
PLoS ONE, 2008 The Kv1.3 potassium channel plays an essential role in effector memory T cells and has been implicated in several important autoimmune diseases including multiple sclerosis, psoriasis and type 1 diabetes.
Yunzhao R Ren +10 more
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Disorder in cellular packing can alter proliferation dynamics to regulate growth [PDF]
Phys. Rev. E 104, L052401 (2021), 2021 Controlling growth via cell division is crucial in the development of higher organisms, and yet the mechanisms through which this is achieved, e.g., in epithelial tissue, is not yet fully understood. We show that by coupling the cell cycle oscillator governing cell division to signals that encode inter-cellular contacts, this phenomenon can be seen as ...
arxiv +1 more source
A transcriptomic taxonomy of Drosophila circadian neurons around the clock
eLife, 2021 Many different functions are regulated by circadian rhythms, including those orchestrated by discrete clock neurons within animal brains. To comprehensively characterize and assign cell identity to the 75 pairs of Drosophila circadian neurons, we ...
Dingbang Ma +6 more
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An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration [PDF]
Nature Cell Biology, 2013 It is generally believed that cytoskeletal activities drive random cell migration, whereas signal transduction events initiated by receptors regulate the cytoskeleton to guide cells. However, we find that the cytoskeletal network, involving SCAR/WAVE, Arp 2/3 and actin-binding proteins, is capable of generating only rapid oscillations and undulations ...
Chuan-Hsiang Huang +4 more
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Synchronization of oscillatory growth prepares fungal hyphae for fusion
eLife, 2023 Communication is crucial for organismic interactions, from bacteria, to fungi, to humans. Humans may use the visual sense to monitor the environment before starting acoustic interactions.
Valentin Wernet +5 more
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Blockage of spontaneous Ca2+ oscillation causes cell death in intraerythrocitic Plasmodium falciparum. [PDF]
PLoS ONE, 2012 Malaria remains one of the world's most important infectious diseases and is responsible for enormous mortality and morbidity. Resistance to antimalarial drugs is a challenging problem in malaria control.
Masahiro Enomoto +6 more
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Cellular tango: How extracellular matrix adhesion choreographs Rac-Rho signaling and cell movement [PDF]
, 2021 The small GTPases Rac and Rho are known to regulate eukaryotic cell shape, promoting front protrusion (Rac) or rear retraction (Rho) of the cell edge. Such cell deformation changes the contact and adhesion of cell to the extracellular matrix (ECM), while ECM signaling through integrin receptors also affects GTPase activity. We develop and investigate a
arxiv +1 more source