Results 31 to 40 of about 1,311,722 (333)

Oscillation dynamics underlie functional switching of NF-κB for B-cell activation. [PDF]

, 2016
Transcription factor nuclear factor kappa B (NF-κB) shows cooperative switch-like activation followed by prolonged oscillatory nuclear translocation in response to extracellular stimuli.
Aihara, Kazuyuki, Behar, Marcelo, Hoffmann, Alexander, Inoue, Kentaro, Okada-Hatakeyama, Mariko, Shinohara, Hisaaki, Tanaka, Gouhei, Yumoto, Noriko   +7 more
core   +1 more source

Multiplexing oscillatory biochemical signals [PDF]

, 2013
In recent years it is increasingly being recognized that biochemical signals are not necessarily constant in time and that the temporal dynamics of a signal can be the information carrier.
de Ronde, Wiet, Wolde, Pieter Rein ten
core   +2 more sources

Photoswitchable diacylglycerols enable optical control of protein kinase C. [PDF]

, 2016
Increased levels of the second messenger lipid diacylglycerol (DAG) induce downstream signaling events including the translocation of C1-domain-containing proteins toward the plasma membrane. Here, we introduce three light-sensitive DAGs, termed PhoDAGs,
A Betz, A Burgalossi, A Nadler, A Nadler, A Wuttke, AC Newton, Alexander Gottschalk, C Yang, Carsten Schultz, CI Bargmann, CJ Nolan, D Toullec, DA Jacobson, DA Jacobson, David J Hodson, DB Konrad, Dirk Trauner, Dmytro A Yushchenko, E Oancea, F Plenge-Tellechea, F Varoqueaux, FM Ashcroft, G Reither, GA Rutter, Guy A Rutter, H Fliegl, H Ishihara, J Basu, J Das, JA Frank, JA Lewis, James Allen Frank, Jatin Nagpal, JD Violin, JD Violin, JE Toettcher, Jeong-Seop Rhee, JM Herbert, JS Rhee, JT Fleming, KDB Wierda, L Coussens, M Almena, M Putyrski, MA Ravier, MA Ravier, MS Pessin, N Brose, N Brose, N Brose, Nils Brose, Noa Lipstein, P Bergsten, PA Marignani, PA Wender, PK Dadi, RJ Davis, S Brenner, S Corbalán-García, S Feng, T Hofmann, TR Mahoney, U Kikkawa, X Lou, Y Kurohane Kaneko, Y Zhao   +65 more
core   +3 more sources

Heat Oscillations Driven by the Embryonic Cell Cycle Reveal the Energetic Costs of Signaling [PDF]

Developmental Cell, 2019
All living systems function out of equilibrium and exchange energy in the form of heat with their environment. Thus, heat flow can inform on the energetic costs of cellular processes, which are largely unknown. Here, we have repurposed an isothermal calorimeter to measure heat flow between developing zebrafish embryos and the surrounding medium.
Jonathan, Rodenfels, Karla M, Neugebauer, Jonathon, Howard   +2 more
openaire   +3 more sources

Blockage of spontaneous Ca2+ oscillation causes cell death in intraerythrocitic Plasmodium falciparum. [PDF]

PLoS ONE, 2012
Malaria remains one of the world's most important infectious diseases and is responsible for enormous mortality and morbidity. Resistance to antimalarial drugs is a challenging problem in malaria control.
Masahiro Enomoto, Shin-ichiro Kawazu, Satoru Kawai, Wakako Furuyama, Tohru Ikegami, Jun-ichi Watanabe, Katsuhiko Mikoshiba   +6 more
doaj   +1 more source

Synchronization of oscillatory growth prepares fungal hyphae for fusion

eLife, 2023
Communication is crucial for organismic interactions, from bacteria, to fungi, to humans. Humans may use the visual sense to monitor the environment before starting acoustic interactions.
Valentin Wernet, Marius Kriegler, Vojtech Kumpost, Ralf Mikut, Lennart Hilbert, Reinhard Fischer   +5 more
doaj   +1 more source

Splice variants of DOMINO control Drosophila circadian behavior and pacemaker neuron maintenance. [PDF]

, 2019
Circadian clocks control daily rhythms in behavior and physiology. In Drosophila, the small ventral lateral neurons (sLNvs) expressing PIGMENT DISPERSING FACTOR (PDF) are the master pacemaker neurons generating locomotor rhythms.
Cai, Yao, Chiu, Joanna C, Lam, Vu H, Liu, Zhenxing, Mcintire, Pearson, Niu, Ye, Tabuloc, Christine A, Xue, Yongbo, Zhang, Yong   +8 more
core   +1 more source

Messages across time and space

eLife, 2020
Compartmentalized oscillations of second messengers affect global cellular signaling.
Sascha M Kuhn, André Nadler
doaj   +1 more source

Receptor-specific Ca2+ oscillation patterns mediated by differential regulation of P2Y purinergic receptors in rat hepatocytes

iScience, 2021
Summary: Extracellular agonists linked to inositol-1,4,5-trisphosphate (IP3) formation elicit cytosolic Ca2+ oscillations in many cell types, but despite a common signaling pathway, distinct agonist-specific Ca2+ spike patterns are observed.
Juliana C. Corrêa-Velloso, Paula J. Bartlett, Robert Brumer, Lawrence D. Gaspers, Henning Ulrich, Andrew P. Thomas   +5 more
doaj   +1 more source

TRPV4-A Missing Link Between Mechanosensation and Immunity [PDF]

, 2020
Transient receptor potential vanilloid-type 4 (TRPV4) cation channel is widely expressed in all tissues as well as in immune cells and its function as mechanosensitive Ca2+ channel seems to be conserved throughout all mammalian species. Of late, emerging
Kuebler, Wolfgang M., Michalick, Laura
core   +1 more source