Results 31 to 40 of about 1,506,122 (305)

Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation

Cell, 2018
Summary How signaling dynamics encode information is a central question in biology. During vertebrate development, dynamic Notch signaling oscillations control segmentation of the presomitic mesoderm (PSM).
Katharina F. Sonnen, Volker M. Lauschke, Julia Uraji, Henning J Falk, Yvonne Petersen, Maja C. Funk, Mathias Beaupeux, P. François, C. Merten, A. Aulehla   +9 more
semanticscholar   +1 more source

Blockage of spontaneous Ca2+ oscillation causes cell death in intraerythrocitic Plasmodium falciparum. [PDF]

PLoS ONE, 2012
Malaria remains one of the world's most important infectious diseases and is responsible for enormous mortality and morbidity. Resistance to antimalarial drugs is a challenging problem in malaria control.
Masahiro Enomoto, Shin-ichiro Kawazu, Satoru Kawai, Wakako Furuyama, Tohru Ikegami, Jun-ichi Watanabe, Katsuhiko Mikoshiba   +6 more
doaj   +1 more source

Messages across time and space

eLife, 2020
Compartmentalized oscillations of second messengers affect global cellular signaling.
Sascha M Kuhn, André Nadler
doaj   +1 more source

Receptor-specific Ca2+ oscillation patterns mediated by differential regulation of P2Y purinergic receptors in rat hepatocytes

iScience, 2021
Summary: Extracellular agonists linked to inositol-1,4,5-trisphosphate (IP3) formation elicit cytosolic Ca2+ oscillations in many cell types, but despite a common signaling pathway, distinct agonist-specific Ca2+ spike patterns are observed.
Juliana C. Corrêa-Velloso, Paula J. Bartlett, Robert Brumer, Lawrence D. Gaspers, Henning Ulrich, Andrew P. Thomas   +5 more
doaj   +1 more source

Autonomous Ca2+ Oscillations Reflect Oncogenic Signaling in B-ALL Cells

Blood, 2019
Background: Engagement of the B-cell receptor (BCR) results in Ca2+ flux and is linked to B-cell survival based on store-operated Ca2+ entry (SOCE), which is triggered by ORAI1 and stromal interaction molecule-1 (STIM1). While normal B-cells release Ca2+ only in response to external stimuli (e.g. BCR-engagement), we recently observed that transformed B-
Kohei Kume, Liting Chen, Jaewoong Lee, Markus Müschen   +3 more
openaire   +1 more source

The circadian clock protein Cryptochrome 1 is a direct target and feedback regulator of the Hippo pathway

iScience, 2023
Summary: Circadian clock controls daily behavior and physiology. The activity of various signaling pathways affects clock gene expression. Here, we show that the core circadian clock gene CRY1 is a direct target of the Hippo pathway effector YAP.
Abdelhalim Azzi, Zhipeng Tao, Yang Sun, Hannah Erb, Carla Guarino, Xu Wu   +5 more
doaj   +1 more source

Clock-modified mesenchymal stromal cells therapy rescues molecular circadian oscillation and age-related bone loss via miR142-3p/Bmal1/YAP signaling axis

Cell Death Discovery, 2022
Age-related bone loss and disease strongly affect the quality of life of the elderly population. Cellular circadian rhythms have been reported to regulate bone aging, and micro RNAs (miRNAs) play crucial posttranscriptional regulatory roles in the ...
Sa Cha, Jiangyue Wang, Sueng Min Lee, Zhen Tan, Qing Zhao, Ding Bai   +5 more
doaj   +1 more source

Human iNKT Cells Promote Protective Inflammation by Inducing Oscillating Purinergic Signaling in Monocyte-Derived DCs [PDF]

Cell Reports, 2016
Invariant natural killer T (iNKT) cells are innate T lymphocytes that promote host defense against a variety of microbial pathogens. Whether microbial ligands are required for their protective effects remains unclear. Here, we show that iNKT cells stimulate human-monocyte-derived dendritic cells (DCs) to produce inflammatory mediators in a manner that ...
Xuequn Xu, Ginger M. Pocock, Akshat Sharma, Stephen L. Peery, J. Scott Fites, Laura Felley, Robert Zarnowski, Douglas Stewart, Erwin Berthier, Bruce S. Klein, Nathan M. Sherer, Jenny E. Gumperz   +11 more
openaire   +3 more sources

Cell Signaling Microdomain with Na,K-ATPase and Inositol 1,4,5-Trisphosphate Receptor Generates Calcium Oscillations [PDF]

Journal of Biological Chemistry, 2003
Recent studies indicate novel roles for the ubiquitous ion pump, Na,K-ATPase, in addition to its function as a key regulator of intracellular sodium and potassium concentration. We have previously demonstrated that ouabain, the endogenous ligand of Na,K-ATPase, can trigger intracellular Ca2+ oscillations, a versatile intracellular signal controlling a ...
Ayako, Miyakawa-Naito, Per, Uhlén, Mark, Lal, Oleg, Aizman, Katsuhiko, Mikoshiba, Hjalmar, Brismar, Sergey, Zelenin, Anita, Aperia   +7 more
openaire   +2 more sources

Resonance in the Mouse Ventral Tegmental Area Dopaminergic Network Induced by Regular and Poisson Distributed Optogenetic Stimulation in-vitro

Frontiers in Computational Neuroscience, 2020
Neurons in many brain regions exhibit spontaneous, intrinsic rhythmic firing activity. This rhythmic firing activity may determine the way in which these neurons respond to extrinsic synaptic inputs. We hypothesized that neurons should be most responsive
Luuk van der Velden, Martin A. Vinck, Wytse J. Wadman   +2 more
doaj   +1 more source