Results 31 to 40 of about 50,029 (292)

Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes. [PDF]

PLoS ONE, 2008
The Kv1.3 potassium channel plays an essential role in effector memory T cells and has been implicated in several important autoimmune diseases including multiple sclerosis, psoriasis and type 1 diabetes.
Yunzhao R Ren, Fan Pan, Suhel Parvez, Andrea Fleig, Curtis R Chong, Jing Xu, Yongjun Dang, Jin Zhang, Hongsi Jiang, Reinhold Penner, Jun O Liu   +10 more
doaj   +1 more source

An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration [PDF]

Nature Cell Biology, 2013
It is generally believed that cytoskeletal activities drive random cell migration, whereas signal transduction events initiated by receptors regulate the cytoskeleton to guide cells. However, we find that the cytoskeletal network, involving SCAR/WAVE, Arp 2/3 and actin-binding proteins, is capable of generating only rapid oscillations and undulations ...
Chuan-Hsiang Huang, Ming Tang, Changji Shi, Pablo A. Iglesias, Peter N. Devreotes   +4 more
openaire   +2 more sources

A transcriptomic taxonomy of Drosophila circadian neurons around the clock

eLife, 2021
Many different functions are regulated by circadian rhythms, including those orchestrated by discrete clock neurons within animal brains. To comprehensively characterize and assign cell identity to the 75 pairs of Drosophila circadian neurons, we ...
Dingbang Ma, Dariusz Przybylski, Katharine C Abruzzi, Matthias Schlichting, Qunlong Li, Xi Long, Michael Rosbash   +6 more
doaj   +1 more source

Synchronization of oscillatory growth prepares fungal hyphae for fusion

eLife, 2023
Communication is crucial for organismic interactions, from bacteria, to fungi, to humans. Humans may use the visual sense to monitor the environment before starting acoustic interactions.
Valentin Wernet, Marius Kriegler, Vojtech Kumpost, Ralf Mikut, Lennart Hilbert, Reinhard Fischer   +5 more
doaj   +1 more source

Blockage of spontaneous Ca2+ oscillation causes cell death in intraerythrocitic Plasmodium falciparum. [PDF]

PLoS ONE, 2012
Malaria remains one of the world's most important infectious diseases and is responsible for enormous mortality and morbidity. Resistance to antimalarial drugs is a challenging problem in malaria control.
Masahiro Enomoto, Shin-ichiro Kawazu, Satoru Kawai, Wakako Furuyama, Tohru Ikegami, Jun-ichi Watanabe, Katsuhiko Mikoshiba   +6 more
doaj   +1 more source

Analysis of circadian pattern reveals tissue-specific alternative transcription in leptin signaling pathway [PDF]

, 2007
*Background* It has been previously reported that most mammalian genes display a circadian oscillation in their baseline expression. Consequently, the phase and amplitude of each component of a signal transduction cascade has downstream ...
A Savitzky, AA Ptitsyn, AA Ptitsyn, Andrey A Ptitsyn, AU Viola, BP Tu, E Selkov, E Selkov, H Yang, HR Ueda, JB Hogenesch, Jeffrey M Gimble, KF Storch, PJ Enriori, RR Klevecz, S Panda, S Zvonic, SN Archer   +17 more
core   +3 more sources

Mathematical models for somite formation [PDF]

, 2007
Somitogenesis is the process of division of the anterior–posterior vertebrate embryonic axis into similar morphological units known as somites. These segments generate the prepattern which guides formation of the vertebrae, ribs and other associated ...
Armstrong, Aulehla, Aulehla, Aulehla, Baker, Baker, Baker, Chernoff, Collier, Cooke, Cooke, Cooke, Dale, Dale, Dale, del Barco Barrantes, Dequéant, Diez del Corral, Diez del Corral, Diez del Corral, Drake, Duband, Dubrulle, Dubrulle, Dubrulle, Dubrulle, Duguay, Foty, Galli, Giudicelli, Goldbeter, Gossler, Grima, Haraguichi, Hirata, Horikawa, Ishikawa, Jiang, Jiang, Kalcheim, Kulesa, Lewis, Maroto, McGrew, McGrew, McInerney, Meier, Molotkova, Monk, Moreno, Morimoto, Packard, Packard, Palmeirim, Pourquié, Pourquié, Pourquié, Pourquié, Pourquié, Pourquié, Primmett, Primmett, Rida, Saga, Schnell, Schnell, Schnell, Stockdale, Tabin, Takahashi, Takashi, Tam, Turner   +72 more
core   +3 more sources

Messages across time and space

eLife, 2020
Compartmentalized oscillations of second messengers affect global cellular signaling.
Sascha M Kuhn, André Nadler
doaj   +1 more source

Cellular Architecture Regulates Collective Calcium Signaling and Cell Contractility.

PLoS Computational Biology, 2016
A key feature of multicellular systems is the ability of cells to function collectively in response to external stimuli. However, the mechanisms of intercellular cell signaling and their functional implications in diverse vascular structures are poorly ...
Jian Sun, James B Hoying, Pierre A Deymier, Donna D Zhang, Pak Kin Wong   +4 more
doaj   +1 more source

An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities

Frontiers in Cell and Developmental Biology, 2020
This article explores and summarizes recent progress in and the characterization of main players in the regulation and cyclic regeneration of hair follicles.
Patrycja Daszczuk, Paula Mazurek, Tomasz D. Pieczonka, Alicja Olczak, Łukasz M. Boryń, Krzysztof Kobielak   +5 more
doaj   +1 more source