Results 41 to 50 of about 1,311,722 (333)

Autonomous Ca2+ Oscillations Reflect Oncogenic Signaling in B-ALL Cells

Blood, 2019
Background: Engagement of the B-cell receptor (BCR) results in Ca2+ flux and is linked to B-cell survival based on store-operated Ca2+ entry (SOCE), which is triggered by ORAI1 and stromal interaction molecule-1 (STIM1). While normal B-cells release Ca2+ only in response to external stimuli (e.g. BCR-engagement), we recently observed that transformed B-
Kohei Kume, Liting Chen, Jaewoong Lee, Markus Müschen   +3 more
openaire   +1 more source

Genetic disruption of the core circadian clock impairs hippocampus-dependent memory [PDF]

, 2014
Perturbing the circadian system by electrolytically lesioning the suprachiasmatic nucleus (SCN) or varying the environmental light:dark schedule impairs memory, suggesting that memory depends on the circadian system.
Chen, Xuanmao, Phan, Trongha X., Saraf, Amit, Storm, Daniel R., Wardlaw, Sarah M.   +4 more
core   +2 more sources

STIM1- and Orai1-mediated Ca2+ oscillation orchestrates invadopodium formation and melanoma invasion

Journal of Cell Biology, 2014
Calcium signaling mediated by STIM1 and Orai1 activates Src to promote invadopodium assembly while simultaneously promoting MT1-MMP recycling to the plasma membrane to promote ECM degradation.
Jianwei Sun, Fujian Lu, Huifang He, Junling Shen, Jane Messina, Rahel A Mathew, Dapeng Wang, A. Sarnaik, Wei-Chiao Chang, Minjung Kim, Heping Cheng, Shengyu Yang   +11 more
semanticscholar   +1 more source

The circadian clock protein Cryptochrome 1 is a direct target and feedback regulator of the Hippo pathway

iScience, 2023
Summary: Circadian clock controls daily behavior and physiology. The activity of various signaling pathways affects clock gene expression. Here, we show that the core circadian clock gene CRY1 is a direct target of the Hippo pathway effector YAP.
Abdelhalim Azzi, Zhipeng Tao, Yang Sun, Hannah Erb, Carla Guarino, Xu Wu   +5 more
doaj   +1 more source

Mathematical models for somite formation [PDF]

, 2007
Somitogenesis is the process of division of the anterior–posterior vertebrate embryonic axis into similar morphological units known as somites. These segments generate the prepattern which guides formation of the vertebrae, ribs and other associated ...
Armstrong, Aulehla, Aulehla, Aulehla, Baker, Baker, Baker, Chernoff, Collier, Cooke, Cooke, Cooke, Dale, Dale, Dale, del Barco Barrantes, Dequéant, Diez del Corral, Diez del Corral, Diez del Corral, Drake, Duband, Dubrulle, Dubrulle, Dubrulle, Dubrulle, Duguay, Foty, Galli, Giudicelli, Goldbeter, Gossler, Grima, Haraguichi, Hirata, Horikawa, Ishikawa, Jiang, Jiang, Kalcheim, Kulesa, Lewis, Maroto, McGrew, McGrew, McInerney, Meier, Molotkova, Monk, Moreno, Morimoto, Packard, Packard, Palmeirim, Pourquié, Pourquié, Pourquié, Pourquié, Pourquié, Pourquié, Primmett, Primmett, Rida, Saga, Schnell, Schnell, Schnell, Stockdale, Tabin, Takahashi, Takashi, Tam, Turner   +72 more
core   +1 more source

Optogenetic perturbation and bioluminescence imaging to analyze cell-to-cell transfer of oscillatory information.

Genes & Development, 2017
Cells communicate with each other to coordinate their gene activities at the population level through signaling pathways. It has been shown that many gene activities are oscillatory and that the frequency and phase of oscillatory gene expression encode ...
Akihiro Isomura, F. Ogushi, H. Kori, R. Kageyama   +3 more
semanticscholar   +1 more source

Human iNKT Cells Promote Protective Inflammation by Inducing Oscillating Purinergic Signaling in Monocyte-Derived DCs [PDF]

Cell Reports, 2016
Invariant natural killer T (iNKT) cells are innate T lymphocytes that promote host defense against a variety of microbial pathogens. Whether microbial ligands are required for their protective effects remains unclear. Here, we show that iNKT cells stimulate human-monocyte-derived dendritic cells (DCs) to produce inflammatory mediators in a manner that ...
Xuequn Xu, Ginger M. Pocock, Akshat Sharma, Stephen L. Peery, J. Scott Fites, Laura Felley, Robert Zarnowski, Douglas Stewart, Erwin Berthier, Bruce S. Klein, Nathan M. Sherer, Jenny E. Gumperz   +11 more
openaire   +3 more sources

A Rho family GTPase controls actin dynamics and tip growth via two counteracting downstream pathways in pollen tubes. [PDF]

, 2005
Tip growth in neuronal cells, plant cells, and fungal hyphae is known to require tip-localized Rho GTPase, calcium, and filamentous actin (F-actin), but how they interact with each other is unclear.
Dowd, Peter, Fu, Ying, Gilroy, Simon, Gu, Ying, Li, Shundai, Vernoud, Vanessa, Yang, Zhenbiao   +6 more
core   +3 more sources

Noise-induced Input Dependence in a Convective Unstable Dynamical System

, 1998
Unidirectionally coupled dynamical system is studied by focusing on the input (or boundary) dependence. Due to convective instability, noise at an up-flow is spatially amplified to form an oscillation. The response, given by the down-flow dynamics, shows
Fujimoto, Koichi, Kaneko, Kunihiko
core   +1 more source

Cell Signaling Microdomain with Na,K-ATPase and Inositol 1,4,5-Trisphosphate Receptor Generates Calcium Oscillations [PDF]

Journal of Biological Chemistry, 2003
Recent studies indicate novel roles for the ubiquitous ion pump, Na,K-ATPase, in addition to its function as a key regulator of intracellular sodium and potassium concentration. We have previously demonstrated that ouabain, the endogenous ligand of Na,K-ATPase, can trigger intracellular Ca2+ oscillations, a versatile intracellular signal controlling a ...
Ayako, Miyakawa-Naito, Per, Uhlén, Mark, Lal, Oleg, Aizman, Katsuhiko, Mikoshiba, Hjalmar, Brismar, Sergey, Zelenin, Anita, Aperia   +7 more
openaire   +2 more sources