Results 51 to 60 of about 306,450 (317)

Microgravity influences circadian clock oscillation in human keratinocytes [PDF]

, 2015
Microgravity and sudden changes of gravitational forces exert numerous effects on tissues, organs and apparatus. Responses to these forces variably applied to cells indicate the existence of mechan- otransduction pathways able to modulate transcription ...
Avitabile, Balsalobre, Bjarnason, Casey, Clement, Czeisler, Dijk, Fuller, Grimm, Grosse, Hargens, Holley, Humphrey, Izumo, Janmey, Mallis, Murakami, Nabavi, Nagaraja, Pardo, Pietsch, Robinson, Shi, Spörl, Wang, Whitson, Wong, Ye, Zanello, Zayzafoon   +29 more
core   +1 more source

Dynamic intracellular mechanical cues facilitate collective signaling responses

iScience, 2021
Summary: Collective behavior emerges in diverse life machineries, e.g., the immune responses to dynamic stimulations. The essential questions that arise here are that whether and how cells in vivo collectively respond to stimulation frequencies higher ...
Bingchen Che, Wei Zhao, Yanan Liu, Dan Sun, Guangyin Jing, Jintao Bai, Xiqiao Feng, Ce Zhang   +7 more
doaj  

Experimental Design for Stochastic Models of Nonlinear Signaling Pathways Using an Interval-Wise Linear Noise Approximation and State Estimation. [PDF]

PLoS ONE, 2016
BACKGROUND:Computational modeling is a key technique for analyzing models in systems biology. There are well established methods for the estimation of the kinetic parameters in models of ordinary differential equations (ODE).
Christoph Zimmer
doaj   +1 more source

Circadian Oscillation Pattern of Endoplasmic Reticulum Quality Control (ERQC) Components in Human Embryonic Kidney HEK293 Cells

Journal of Circadian Rhythms, 2023
The circadian clock regulates the “push-pull” of the molecular signaling mechanisms that arrange the rhythmic organization of the physiology to maintain cellular homeostasis. In mammals, molecular clock genes tightly arrange cellular rhythmicity.
Yalcin Erzurumlu, Deniz Catakli, Hatice Kubra Dogan   +2 more
doaj   +1 more source

Genetic disruption of the core circadian clock impairs hippocampus-dependent memory [PDF]

, 2014
Perturbing the circadian system by electrolytically lesioning the suprachiasmatic nucleus (SCN) or varying the environmental light:dark schedule impairs memory, suggesting that memory depends on the circadian system.
Chen, Xuanmao, Phan, Trongha X., Saraf, Amit, Storm, Daniel R., Wardlaw, Sarah M.   +4 more
core   +2 more sources

Miro1-dependent mitochondrial dynamics in parvalbumin interneurons

eLife, 2021
The spatiotemporal distribution of mitochondria is crucial for precise ATP provision and calcium buffering required to support neuronal signaling.
Georgina Kontou, Pantelis Antonoudiou, Marina Podpolny, Blanka R Szulc, I Lorena Arancibia-Carcamo, Nathalie F Higgs, Guillermo Lopez-Domenech, Patricia C Salinas, Edward O Mann, Josef T Kittler   +9 more
doaj   +1 more source

Splice variants of DOMINO control Drosophila circadian behavior and pacemaker neuron maintenance. [PDF]

, 2019
Circadian clocks control daily rhythms in behavior and physiology. In Drosophila, the small ventral lateral neurons (sLNvs) expressing PIGMENT DISPERSING FACTOR (PDF) are the master pacemaker neurons generating locomotor rhythms.
Cai, Yao, Chiu, Joanna C, Lam, Vu H, Liu, Zhenxing, Mcintire, Pearson, Niu, Ye, Tabuloc, Christine A, Xue, Yongbo, Zhang, Yong   +8 more
core   +1 more source

Lattice gas cellular automata model for rippling and aggregation in myxobacteria

, 2004
A lattice-gas cellular automaton (LGCA) model is used to simulate rippling and aggregation in myxobacteria. An efficient way of representing cells of different cell size, shape and orientation is presented that may be easily extended to model later ...
Buchard, Börner, Dworkin, Gronewold, Hagen, Hodgkin, Hodgkin, Igoshin, Jelsbak, Jelsbak, Jiang, Julien, Kim, Kim, Kim, Kim, Kim, Kroos, Kruse, Li, Lutscher, Marée, Reichenbach, Sager, Sager, Shi, Shimkets, Shimkets, Shimkets, Stevens, Vasquez, Welch, Wolgemuth   +32 more
core   +1 more source

p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. [PDF]

, 2013
The p75 neurotrophin receptor (p75(NTR)) is a member of the tumor necrosis factor receptor superfamily with a widespread pattern of expression in tissues such as the brain, liver, lung, and muscle.
Akassoglou, Katerina, Baeza-Raja, Bernat, Eckel-Mahan, Kristin, Ptácek, Louis J, Sassone-Corsi, Paolo, Tsigelny, Igor F, Vagena, Eirini, Zhang, Luoying   +7 more
core   +2 more sources

Mechanical Stretch Induces mTOR Recruitment and Activation at the Phosphatidic Acid-Enriched Macropinosome in Muscle Cell

Frontiers in Cell and Developmental Biology, 2019
The mammalian target of rapamycin (mTOR) is an evolutionarily conserved kinase which assembles a signaling network that integrates diverse biochemical and mechanical cues to coordinate cell growth and proliferation.
Shan-Shan Lin, Ya-Wen Liu, Ya-Wen Liu
doaj   +1 more source