Results 51 to 60 of about 1,502,276 (251)
Photoswitchable diacylglycerols enable optical control of protein kinase C. [PDF]
, 2016 Increased levels of the second messenger lipid diacylglycerol (DAG) induce downstream signaling events including the translocation of C1-domain-containing proteins toward the plasma membrane. Here, we introduce three light-sensitive DAGs, termed PhoDAGs,
A Betz +65 more
core +3 more sources
Entrainment of heterogeneous glycolytic oscillations in single cells [PDF]
Scientific Reports 5 (2015) 9404, 2015 Cell signaling, gene expression, and metabolism are affected by cell-cell heterogeneity and random changes in the environment. The effects of such fluctuations on cell signaling and gene expression have recently been studied intensively using single-cell experiments.
arxiv +1 more source
FGF signaling controls somite boundary position and regulates segmentation clock control of spatiotemporal Hox gene activation [PDF]
, 2001 Vertebrate segmentation requires a molecular oscillator, the segmentation clock, acting in presomitic mesoderm (PSM) cells to set the pace at which segmental boundaries are laid down. However, the signals that position each boundary remain unclear. Here,
Dubrulle, J, McGrew, M J, Pourquié, O
core +2 more sources
Spontaneous Spatiotemporal Ordering of Shape Oscillations Enhances Cell Migration [PDF]
Soft Matter 15, 4939 (2019), 2019 The migration of cells is relevant for processes such as morphogenesis, wound healing, and invasion of cancer cells. In order to move, single cells deform cyclically. However, it is not understood how these shape oscillations influence collective properties.
arxiv +1 more source
Frontiers in Computational Neuroscience, 2020 Neurons in many brain regions exhibit spontaneous, intrinsic rhythmic firing activity. This rhythmic firing activity may determine the way in which these neurons respond to extrinsic synaptic inputs. We hypothesized that neurons should be most responsive
Luuk van der Velden +2 more
doaj +1 more source
Splice variants of DOMINO control Drosophila circadian behavior and pacemaker neuron maintenance. [PDF]
, 2019 Circadian clocks control daily rhythms in behavior and physiology. In Drosophila, the small ventral lateral neurons (sLNvs) expressing PIGMENT DISPERSING FACTOR (PDF) are the master pacemaker neurons generating locomotor rhythms.
Cai, Yao +8 more
core +1 more source
Molecular Pharmacology, 2009 Agonist stimulation of the type 5 metabotropic glutamate (mGlu5) receptor initiates robust oscillatory changes in cytosolic Ca2+ concentration ([Ca2+]i) in single cells by rapid, repeated cycles of phosphorylation/dephosphorylation of the mGlu5 receptor,
S. Bradley, J. Watson, R. Challiss
semanticscholar +1 more source
Genetic disruption of the core circadian clock impairs hippocampus-dependent memory [PDF]
, 2014 Perturbing the circadian system by electrolytically lesioning the suprachiasmatic nucleus (SCN) or varying the environmental light:dark schedule impairs memory, suggesting that memory depends on the circadian system.
Chen, Xuanmao +4 more
core +2 more sources
Genes & Development, 2017 Cells communicate with each other to coordinate their gene activities at the population level through signaling pathways. It has been shown that many gene activities are oscillatory and that the frequency and phase of oscillatory gene expression encode ...
Akihiro Isomura +3 more
semanticscholar +1 more source
Dynamic intracellular mechanical cues facilitate collective signaling responses
iScience, 2021 Summary: Collective behavior emerges in diverse life machineries, e.g., the immune responses to dynamic stimulations. The essential questions that arise here are that whether and how cells in vivo collectively respond to stimulation frequencies higher ...
Bingchen Che +7 more
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