Results 11 to 20 of about 18,733 (222)

DKK1 and Kremen Expression Predicts the Osteoblastic Response to Bone Metastasis

Translational Oncology, 2018
Bone metastasis is a complication of advanced breast and prostate cancer. Tumor-secreted Dickkopf homolog 1 (DKK1), an inhibitor of canonical Wnt signaling and osteoblast differentiation, was proposed to regulate the osteoblastic response to metastatic ...
Katrina L. Clines, Gregory A. Clines
doaj   +3 more sources

The host microenvironment influences prostate cancer invasion, systemic spread, bone colonization, and osteoblastic metastasis [PDF]

Frontiers in Oncology, 2014
Prostate cancer (PCa) is the second leading cause of cancer death in men worldwide. Most PCa patients die with osteoblastic bone metastases. What triggers PCa metastasis to the bone and what causes osteoblastic lesions remain unanswered.
Sourik S Ganguly, Xiaohong eLi, Cindy K Miranti   +2 more
doaj   +3 more sources

Canine prostatic cancer cell line (LuMa) with osteoblastic bone metastasis. [PDF]

Prostate, 2020
AbstractBackgroundOsteoblastic bone metastasis represents the most common complication in men with prostate cancer (PCa). During progression and bone metastasis, PCa cells acquire properties similar to bone cells in a phenomenon called osteomimicry, which promotes their ability to metastasize, proliferate, and survive in the bone microenvironment.
Elshafae SM, Dirksen WP, Alasonyalilar-Demirer A, Breitbach J, Yuan S, Kantake N, Supsavhad W, Hassan BB, Attia Z, Alstadt LB, Rosol TJ.   +10 more
europepmc   +5 more sources

GDF15 promotes prostate cancer bone metastasis and colonization through osteoblastic CCL2 and RANKL activation [PDF]

Bone Research, 2022
Bone metastases occur in patients with advanced-stage prostate cancer (PCa). The cell-cell interaction between PCa and the bone microenvironment forms a vicious cycle that modulates the bone microenvironment, increases bone deformities, and drives tumor ...
Jawed Akhtar Siddiqui, Parthasarathy Seshacharyulu, Sakthivel Muniyan, Ramesh Pothuraju, Parvez Khan, Raghupathy Vengoji, Sanjib Chaudhary, Shailendra Kumar Maurya, Subodh Mukund Lele, Maneesh Jain, Kaustubh Datta, Mohd Wasim Nasser, Surinder Kumar Batra   +12 more
doaj   +4 more sources

Mechanisms of Osteoblastic Bone Metastasis in Prostate Cancer: Role of Prostatic Acid Phosphatase. [PDF]

J Endocr Soc, 2019
Abstract Prostate cancer (PCa) preferentially metastasizes to bone, leading to complications including severe pain, fractures, spinal cord compression, bone marrow suppression, and a mortality of ∼70%. In spite of recent advances in chemo-, hormonal, and radiation therapies, bone-metastatic, castrate-resistant PCa is incurable.
Quiroz-Munoz M, Izadmehr S, Arumugam D, Wong B, Kirschenbaum A, Levine AC.   +5 more
europepmc   +4 more sources

Osteoblastic Factors in Prostate Cancer Bone Metastasis [PDF]

Current Osteoporosis Reports, 2018
Prostate cancer bone metastasis is the lethal progression of the disease. The disease frequently presents with osteoblastic lesions in bone. The tumor-induced bone can cause complications that significantly hamper the quality of life of patients. A better understanding of how prostate cancer induces aberrant bone formation and how the aberrant bone ...
Song-Chang, Lin, Li-Yuan, Yu-Lee, Sue-Hwa, Lin   +2 more
openaire   +2 more sources

Relationship between clinical features and gene mutations in non-small cell lung cancer with osteoblastic bone metastasis

Cancer Treatment and Research Communications, 2021
Objective: Lung cancer patients presenting with osteoblastic bone metastases at the first visit is rare. We investigated the clinical characteristics and gene mutation rate of non-small cell lung cancer patients with osteoblastic bone metastases at the ...
Yutaka Takahara, Keisuke Nakase, Masafumi Nojiri, Ryo Kato, Shohei Shinomiya, Taku Oikawa, Shiro Mizuno   +6 more
doaj   +1 more source

Ovarian cancer with osteoblastic bone metastasis – A rare case report

Journal of Cancer Research and Therapeutics, 2023
ABSTRACT Ovarian cancer with bone involvement occurs rarely with an incidence of 0.1–0.12%. The common sites of bone metastasis are vertebrae, pelvic bones, and the skull. Patients present with severe localized bone pain, swelling, and difficulty in walking.
Saloni, Singhal, Ruchi, Sharma, Somya, Sharma, Ashar I, Lodi, Virendra, Bhandari   +4 more
openaire   +2 more sources

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Cellular and molecular mediators of bone metastatic lesions [PDF]

, 2018
Bone is the preferential site of metastasis for breast and prostate tumor. Cancer cells establish a tight relationship with the host tissue, secreting factors that stimulate or inhibit bone cells, receiving signals generated from the bone remodeling ...
Battafarano, Giulia, Del Fattore, Andrea, Marampon, Francesco, Rossi, Michela   +3 more
core   +5 more sources