Results 21 to 30 of about 18,733 (222)

Osteoblastic Bone Metastasis from Pancreatic Adenocarcinoma: One Case Report

Zhongliu Fangzhi Yanjiu, 2018
WANG Yongpeng, SUN Gaofeng
doaj   +2 more sources

Accurate Monitoring of the Response of Bone Metastases to Treatment in Patients with Prostate Cancer Using Choline PET/CT

Case Reports in Oncology, 2021
We here report 2 cases of castration-resistant prostate cancer (CRPC) observed two times on 11C-choline positron emission tomography computed tomography (PET/CT), which was useful to discriminate viable progressive osteoblastic bone metastasis from ...
Kazuhiro Kitajima, Shingo Yamamoto, Masayuki Fujiwara, Yusuke Kawanaka, Yusuke Yamada, Seiji Nagasawa, Kimihiro Shimatani, Takeshi Hanasaki, Motohiro Taguchi, Akihiro Kanematsu, Koichiro Yamakado   +10 more
doaj   +1 more source

Osteoblast‐derived extracellular vesicles exert osteoblastic and tumor‐suppressive functions via SERPINA3 and LCN2 in prostate cancer

Molecular Oncology, 2023
Clinically, the osteolytic phenotype is rare in prostate cancer (PCa), and the prognosis is generally worse than that of the osteoblastic phenotype. Osteoblastic prostate cancer (BPCa) is a major type of bone metastasis.
Kagenori Ito, Tomofumi Yamamoto, Yusuke Hayashi, Shun Sato, Jun Nakayama, Fumihiko Urabe, Takeo Shimasaki, Eijiro Nakamura, Yoshiyuki Matui, Hiroyuki Fujimoto, Takahiro Kimura, Shin Egawa, Takahiro Ochiya, Yusuke Yamamoto   +13 more
doaj   +1 more source

The link between bone-derived factors osteocalcin, fibroblast growth factor 23, sclerostin, lipocalin 2 and tumor bone metastasis

Frontiers in Endocrinology, 2023
The skeleton is the third most common site of metastatic disease, which causes serious bone complications and short-term prognosis in cancer patients.
Monika Martiniakova, Vladimira Mondockova, Roman Biro, Veronika Kovacova, Martina Babikova, Nina Zemanova, Sona Ciernikova, Radoslav Omelka   +7 more
doaj   +1 more source

The molecular signature of the stroma response in prostate cancer-induced osteoblastic bone metastasis highlights expansion of hematopoietic and prostate epithelial stem cell niches. [PDF]

PLoS ONE, 2014
The reciprocal interaction between cancer cells and the tissue-specific stroma is critical for primary and metastatic tumor growth progression. Prostate cancer cells colonize preferentially bone (osteotropism), where they alter the physiological balance ...
Berna C Özdemir, Janine Hensel, Chiara Secondini, Antoinette Wetterwald, Ruth Schwaninger, Achim Fleischmann, Wolfgang Raffelsberger, Olivier Poch, Mauro Delorenzi, Ramzi Temanni, Ian G Mills, Gabri van der Pluijm, George N Thalmann, Marco G Cecchini   +13 more
doaj   +1 more source

Technical Case Report of a Cranioplasty With ex vivo Frozen Ostoblastic Bone Graft From Large Skull Metastasis

Frontiers in Surgery, 2021
Objective: Liquid nitrogen cryotherapy has shown efficacy in the treatment of bone tumors of the extremities with good oncologic and functional outcomes.
Pang-Shuo Perng, Po-Hsuan Lee, Hao-Hsiang Hsu, Chi-Chen Huang, Chih-Yuan Huang, Jung-Shun Lee, Jung-Shun Lee, Jung-Shun Lee   +7 more
doaj   +1 more source

The role of osteoblasts in bone metastasis [PDF]

Journal of Bone Oncology, 2016
The primary role of osteoblasts is to lay down new bone during skeletal development and remodelling. Throughout this process osteoblasts directly interact with other cell types within bone, including osteocytes and haematopoietic stem cells. Osteoblastic cells also signal indirectly to bone-resorbing osteoclasts via the secretion of RANKL.
openaire   +4 more sources

Acid-Induced Inflammatory Cytokines in Osteoblasts: A Guided Path to Osteolysis in Bone Metastasis [PDF]

Frontiers in Cell and Developmental Biology, 2021
Bone metastasis (BM) is a dismal complication of cancer that frequently occurs in patients with advanced carcinomas and that often manifests as an osteolytic lesion. In bone, tumor cells promote an imbalance in bone remodeling via the release of growth factors that, directly or indirectly, stimulate osteoclast resorption activity.
Gemma Di Pompo, Costantino Errani, Robert Gillies, Laura Mercatali, Toni Ibrahim, Jacopo Tamanti, Nicola Baldini, Nicola Baldini, Sofia Avnet, Sofia Avnet   +9 more
openaire   +4 more sources

Targeting bone remodeling by isoflavone and 3,3'-diindolylmethane in the context of prostate cancer bone metastasis. [PDF]

PLoS ONE, 2012
Prostate cancer (PCa) bone metastases have long been believed to be osteoblastic because of bone remodeling leading to the formation of new bone. However, recent studies have shown increased osteolytic activity in the beginning stages of PCa bone ...
Yiwei Li, Dejuan Kong, Aamir Ahmad, Bin Bao, Fazlul H Sarkar   +4 more
doaj   +1 more source

Pathogenesis of bone metastasis

Journal of Oncological Sciences, 2016
Bone metastases are more frequently seen as a complication of cancer than primary bone tumors. For example, it can be seen in as many as 70% of advanced stage breast and prostate cancer cases.
Erdinc Nayir
doaj   +1 more source