Results 51 to 60 of about 5,649,689 (153)

JAK2 Inhibition by Fedratinib Reduces Osteoblast Differentiation and Mineralisation of Human Mesenchymal Stem Cells

Molecules, 2021
Several signalling pathways, including the JAK/STAT signalling pathway, have been identified to regulate the differentiation of human bone marrow skeletal (mesenchymal) stem cells (hBMSCs) into bone-forming osteoblasts.
Nihal AlMuraikhi, Hanouf Alaskar, Sarah Binhamdan, Amal Alotaibi, Moustapha Kassem, Musaad Alfayez   +5 more
doaj   +1 more source

Manifestation of osteoblastic phenotypes in the sarcomatous component of epithelial carcinoma and sarcomatoid carcinoma

Tumor Biology, 2017
Epithelial carcinomas occasionally have sarcomatous components that consist primarily of spindle and cuboidal cells, which often resemble osteoblasts. Sarcomatoid carcinomas consist of similar cells. Recent studies have characterized these phenomena as a
Yasutoshi Takashima, Teppei Murakami, Takao Inoue, Man Hagiyama, Azusa Yoneshige, Syunji Nishimura, Masao Akagi, Akihiko Ito   +7 more
doaj   +1 more source

In vitro characterization of immune-related properties of human fetal bone cells for potential tissue engineering applications [PDF]

, 2009
We describe herein some immunological properties of human fetal bone cells recently tested for bone tissue-engineering applications. Adult mesenchymal stem cells (MSCs) and osteoblasts were included in the study for comparison.
Martin, I, Arnaud Scherberich, Montjovent, MO, Scherberich, A, Scherberich, Arnaud, Lee Ann Applegate, Montjovent, Marc-Olivier, Marc-Olivier Montjovent, Scaletta, Corinne, Dominique P. Pioletti, Bocelli-Tyndall, Chiara, Martin, Ivan, Applegate, LA, Laurent-Applegate, Lee, Bocelli-Tyndall, C., Pioletti, DP, Scherberich, A., Silke Mark, Montjovent, M.O., Scaletta, C, Pioletti, Dominique P., Mark, Silke, Mark, S., Bocelli-Tyndall, C, Applegate, Lee Ann, Mark, S, Pioletti, D.P., Corinne Scaletta, Scaletta, C., Ivan Martin, Martin, I., Applegate, L.A., Chiara Bocelli-Tyndall, Applegate LA, Pioletti DP, Mark S, Martin I, Bocelli-Tyndall C, Montjovent MO, Scaletta C, Scherberich A, Montjovent, Marc-Oliver   +41 more
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The Osteoblastic Microenvironment Determines the Fate of Breast Cancer Cells Disseminated in the Bone Marrow

Advanced Science
Bone is the most common destination of metastatic breast cancer cells. Upon dissemination to the bone, cancer cells may either colonize aggressively or enter a quiescent state, depending on interactions with the bone microenvironment. This study revealed
Hong‐Li Wang, Rui Zhang, Xiao‐Min Yue, Jie Zhou, Yu‐Fan Huang, Rong Meng, Yu‐Li Wang, Xiao‐Qing Li   +7 more
doaj   +1 more source

Prostate cancer bone metastases promote both osteolytic and osteoblastic activity [PDF]

, 2004
Advanced prostate cancer is frequently accompanied by the development of metastasis to bone. In the past, prostate cancer bone metastases were characterized as being osteoblastic (i.e., increasing bone density) based on radiographs.
Brown, Julie, Keller, Evan T.
core   +1 more source

Osteoblastic cell behavior on nanostructured metal implants.

, 2008
Item does not contain fulltextAIMS: Surface modifications at the nanometric scale may promote protein adsorption, cell adhesion and thus favor the osseointegration of metal implants.
Layrolle, P., Lopez-Heredia, M.A., Guehennec, L. Le, Martin, F., Lopez, M.A., Louarn, G., Amouriq, Y., Cousty, J., Le Guehennec, L.   +8 more
core   +1 more source

Periostin inhibits mechanical stretch-induced apoptosis in osteoblast-like MG-63 cells

Journal of the Formosan Medical Association, 2018
Background/purpose: Appropriate mechanical stress plays an important role in regulating the proliferation and differentiation of osteoblasts, whereas high-level mechanical stress may be harmful and compromise cell survival.
Kai-Wen Yu, Chung-Chen Yao, Jiiang-Huei Jeng, Hao-Ying Shieh, Yi-Jane Chen   +4 more
doaj   +1 more source

Gene expression analysis in osteoblastic differentiation from peripheral blood mesenchymal stem cells

, 2008
MSCs are known to have an extensive proliferative potential and ability to differentiate in various cell types. Osteoblastic differentiation from mesenchymal progenitor cells is an important step of bone formation, though the pattern of gene expression
DONATELLI, Luca, LO CASCIO, Vincenzo, ZANATTA, Mirko, DALLE CARBONARE, Luca Giuseppe, BERTOLDO, Francesco, VALENTI, Maria Teresa   +5 more
core   +1 more source

Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors

, 1995
We reported that interleukin (IL) 6 alone cannot induce osteoclast formation in cocultures of mouse bone marrow and osteoblastic cells, but soluble IL-6 receptor (IL-6R) strikingly triggered osteoclast formation induced by IL-6.
Taga, T, Takahashi, N, Findlay, DM, Hirota, H, John Martin, T, Udagawa, N, Katagiri, T, Wada, S, Tamura, T, Kishimoto, T, Suda, T   +10 more
core   +1 more source

Functionalizing biomaterials for osseointegration – microRNAs at the crossroads of bone formation and immune modulation

Bone & Joint Research
MicroRNAs (miRNAs) play an important role in post-transcriptional gene regulation by binding to messenger RNA and thereby modulating protein synthesis and affecting cellular functions such as proliferation and apoptosis. In bone biology, miRNAs influence
Mandana Azari, Elena Della Bella, Britt Wildemann   +2 more
doaj   +1 more source