Results 61 to 70 of about 4,458,897 (200)

Protease-activated receptor-2 promotes osteogenesis in skeletal mesenchymal stem cells at the expense of adipogenesis: Involvement of interleukin-6

Bone Reports, 2021
Bone marrow mesenchymal stem cells (MSCs) give rise to osteoblasts and adipocytes, with an inverse relationship between the two. The MSCs from protease-activated receptor-2 knockout (PAR2 KO) mice have a reduced capacity to generate osteoblasts.
R. Sanaei, P.K. Kularathna, N. Taghavi, J.D. Hooper, C.N. Pagel, E.J. Mackie   +5 more
doaj   +1 more source

Cell‐cell interactions in regulating osteogenesis and osteoblast function [PDF]

Birth Defects Research Part C: Embryo Today: Reviews, 2005
AbstractEndochondral bone formation requires an elaborate interplay among autocrine, paracrine, and endocrine signals, positional cues, and cell‐cell contacts to mediate the complex three‐dimensional architecture and function of the skeleton. Embryonic bone development occurs by migration, aggregation, and condensation of immature mesenchymal ...
Joseph P, Stains, Roberto, Civitelli
openaire   +2 more sources

Vinpocetine Attenuates the Osteoblastic Differentiation of Vascular Smooth Muscle Cells. [PDF]

, 2016
Vascular calcification is an active process of osteoblastic differentiation of vascular smooth muscle cells; however, its definite mechanism remains unknown.
Qiu-Hua Liang, Yu-Zhong Wang, Yun-Yun Ma, Xiu-Juan Chen, Na Wang, Peng-Fei Yi, Bo Zhang, Lin Sun, Min Song   +8 more
core   +1 more source

Steroid Formation in Osteoblast-Like Cells

Journal of International Medical Research, 1998
For preventing the reduction of bone mass in post-menopausal women, oestrogen replacement is known to be useful and the importance of sex steroids in bone metabolism in both sexes is well established. The presence of steroid-converting-enzyme activities in various osteoblast and osteoblast-like cells has been demonstrated using in vitro culture systems.
H, Saito, T, Yanaihara
openaire   +2 more sources

Osteoblastic cells regulate the haematopoietic stem cell niche [PDF]

Nature, 2003
Stem cell fate is influenced by specialized microenvironments that remain poorly defined in mammals. To explore the possibility that haematopoietic stem cells derive regulatory information from bone, accounting for the localization of haematopoiesis in bone marrow, we assessed mice that were genetically altered to produce osteoblast-specific, activated
L M, Calvi, G B, Adams, K W, Weibrecht, J M, Weber, D P, Olson, M C, Knight, R P, Martin, E, Schipani, P, Divieti, F R, Bringhurst, L A, Milner, H M, Kronenberg, D T, Scadden   +12 more
openaire   +2 more sources

Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia

, 2012
Pancytopenia is a major cause of morbidity in acute myeloid leukemia (AML), yet its cause is unclear. Normal osteoblastic cells have been shown to support hematopoiesis.
Craig T. Jordan, Michael W. Becker, John M. Ashton, Laura M. Calvi, Benjamin J. Frisch, Lianping Xing   +5 more
core   +2 more sources

The Osteoblastic Microenvironment Determines the Fate of Breast Cancer Cells Disseminated in the Bone Marrow

Advanced Science
Bone is the most common destination of metastatic breast cancer cells. Upon dissemination to the bone, cancer cells may either colonize aggressively or enter a quiescent state, depending on interactions with the bone microenvironment. This study revealed
Hong‐Li Wang, Rui Zhang, Xiao‐Min Yue, Jie Zhou, Yu‐Fan Huang, Rong Meng, Yu‐Li Wang, Xiao‐Qing Li   +7 more
doaj   +1 more source

Periostin inhibits mechanical stretch-induced apoptosis in osteoblast-like MG-63 cells

Journal of the Formosan Medical Association, 2018
Background/purpose: Appropriate mechanical stress plays an important role in regulating the proliferation and differentiation of osteoblasts, whereas high-level mechanical stress may be harmful and compromise cell survival.
Kai-Wen Yu, Chung-Chen Yao, Jiiang-Huei Jeng, Hao-Ying Shieh, Yi-Jane Chen   +4 more
doaj   +1 more source

PIEZO1 and TRPV4, which Are Distinct Mechano-Sensors in the Osteoblastic MC3T3-E1 Cells, Modify Cell-Proliferation

, 2019
Mechanical-loading and unloading can modify osteoblast functioning. Ca2+ signaling is one of the earliest events in osteoblasts to induce a mechanical stimulus, thereby demonstrating the importance of the underlying mechanical sensors for the sensation ...
Hiroka Suzuki, Miyazawa, Ken, Goto, Shigemi, Nakano, Sayumi, Shigemi Goto, Maki Yoneda, Katsuhiko Muraki, Suzuki, Hiroka, Muraki, Katsuhiko, Yukiko Muraki, Ken Miyazawa, Sayumi Nakano, Yoneda, Maki, Muraki, Yukiko, Noriyuki Hatano, Hatano, Noriyuki   +15 more
core   +1 more source

Effects of eluted components from 4-META/MMA-TBB adhesive resin sealer on osteoblastic cell proliferation

Journal of Dental Sciences, 2012
Background/purpose: Adhesive resin sealer systems are applied to seal root-canal systems more effectively through the formation of a resin impregnation layer.
Aya Kawasaki, Yoshihiko Hayashi, Kajiro Yanagiguchi, Shizuka Yamada, Minoru Syudo, Kazunari Igawa, Takeshi Ikeda, Shisei Kubo, Mamoru Fujiwara   +8 more
doaj   +1 more source