Decorin Promotes Osteoblastic Differentiation of Human Periodontal Ligament Stem Cells [PDF]
Molecules, 2022 The aim of this study is to clarify the biological functions of decorin (DCN) in the healing and regeneration of wounded periodontal tissue. We investigated the expression pattern of DCN during the healing of wounded periodontal tissue in rats by ...
Orie Adachi +13 more
doaj +2 more sources
OstemiR: a novel panel of microRNA biomarkers in osteoblastic and osteocytic differentiation from mesencymal stem cells. [PDF]
PLoS ONE, 2013 MicroRNAs (miRNAs) are small RNA molecules of 21-25 nucleotides that regulate cell behavior through inhibition of translation from mRNA to protein, promotion of mRNA degradation and control of gene transcription.
Takanori Eguchi +5 more
doaj +8 more sources
The importance of cellular and exosomal miRNAs in mesenchymal stem cell osteoblastic differentiation [PDF]
Scientific Reports, 2021 The differentiation of osteoblasts is under complex regulation that includes autocrine and paracrine signaling from MSCs. Exosomes are important components of the MSC secretome and their cargo contains numerous miRNAs.
Sajjad Shirazi +5 more
doaj +2 more sources
The role of lysophosphatidylcholine acyltransferase 2 in osteoblastic differentiation of C2C12 cells [PDF]
FEBS Open BioGlycerophospholipids, a primary component of cellular membranes, play important structural and functional roles in cells. In the remodelling pathway (Lands' cycle), the concerted actions of phospholipase As and lysophospholipid acyltransferases (LPLATs ...
Shirou Tabe +5 more
doaj +2 more sources
An In Vitro Evaluation of Selenium Nanoparticles on Osteoblastic Differentiation and Antimicrobial Properties against Porphyromonas gingivalis [PDF]
Nanomaterials, 2022 Despite numerous treatment methods, there is no gold standard for the treatment of peri-implantitis—an infectious peri-implant disease. Here, we examined selenium nanoparticles (SeNPs) at a wide range of concentrations to investigate their cytotoxicity ...
Jason Hou +6 more
doaj +2 more sources
Promotion effect of apical tooth germ cell-conditioned medium on osteoblastic differentiation of periodontal ligament stem cells through regulating miR-146a-5p [PDF]
BMC Oral Health, 2022 Background MicroRNAs (miRNAs) play an important role in gene regulation that controls stem cells differentiation. Periodontal ligament stem cells (PDLSCs) could differentiate into osteo-/cementoblast-like cells that secretes cementum-like matrix both in ...
Yueqiang Xie +3 more
doaj +2 more sources
Substrate Stiffness Controls Osteoblastic and Chondrocytic Differentiation of Mesenchymal Stem Cells without Exogenous Stimuli [PDF]
, 2017 Stem cell fate has been linked to the mechanical properties of their underlying substrate, affecting mechanoreceptors and ultimately leading to downstream biological response.
Boyan, Barbara D. +8 more
core +27 more sources
Enhanced osteogenic differentiation in zoledronate-treated osteoporotic patients [PDF]
, 2017 Bisphosphonates are well known inhibitors of osteoclast activity and thus may be employed to influence osteoblast activity. The present study was designed to evaluate the in vivo effects of zoledronic acid (ZA) on the proliferation and osteoblastic ...
Carbonare, Luca Dalle +7 more
core +14 more sources
Journal of Dental Sciences, 2021 Background/purpose: PDLSCs (periodontal ligament stem cells), derived from dental tissues, are candidate cells for regeneration of dental tissues. MiRNAs could regulate osteogenic differentiation and the transformation into osteoblasts.
Chunying Li, Guanglin Duan, Yaopu Feng
doaj +1 more source
lncRNA TUG1 promotes proliferation and differentiation of osteoblasts by regulating the miR-545-3p/CNR2 axis [PDF]
Brazilian Journal of Medical and Biological Research, 2020 Osteoblast differentiation is an effective way to promote bone formation. Long non-coding RNA taurine upregulated 1 (TUG1) has been identified as a crucial modulator of multiple biological processes. This study was designed to investigate the function of
Ruizheng Hao +4 more
doaj +1 more source