Results 51 to 60 of about 65,828 (262)

Histomorphometric evaluation of bone regeneration induced by biodegradable scaffolds as carriers for dental pulp stem cells in a rat model of calvarial "critical size" defect [PDF]

, 2016
Objective: The aim of this study was to test specific stem cells that could enhance bone formation in combination with specific scaffolds. Methods: Dental Pulp Stem Cells (DPSCs) were seeded with Granular Deproteinized Bovine Bone (GDPB) or Beta ...
ANNIBALI, Susanna, BELLAVIA, Diana, CICCONETTI, Andrea, CRISTALLI, MARIA PAOLA, OTTOLENGHI, Livia, PILLONI, ANDREA, QUARANTA, ROBERTA, Scarano, Antonio   +7 more
core   +1 more source

Indirect osteoblast differentiation by liposomal clodronate [PDF]

Journal of Cellular and Molecular Medicine, 2017
AbstractBisphosphonates impair function of osteoclasts and prevent bone resorption, the mechanism of which has been studied extensively. However, the possible effects of bisphosphonates on chondroblast differentiation and calcium deposition by osteoblasts have only been demonstrated recently.
Emi Okada, Hidemi Nakata, Maiko Yamamoto, Shohei Kasugai, Shinji Kuroda   +4 more
openaire   +2 more sources

Effect of Menin Deletion in Early Osteoblast Lineage on the Mineralization of an In Vitro 3D Osteoid-like Dense Collagen Gel Matrix

Biomimetics, 2022
Bone has a complex microenvironment formed by an extracellular matrix (ECM) composed mainly of mineralized type I collagen fibres. Bone ECM regulates signaling pathways important in the differentiation of osteoblast-lineage cells, necessary for bone ...
Ildi Troka, Gabriele Griffanti, Lucie Canaff, Geoffrey N. Hendy, David Goltzman, Showan N. Nazhat   +5 more
doaj   +1 more source

Investigation of the role of the miR17-92 cluster in BMP9-induced osteoblast lineage commitment

Journal of Orthopaedic Surgery and Research, 2021
Background Bone morphogenetic protein 9 (BMP9) has been identified as a crucial inducer of osteoblastic differentiation in mesenchymal stem cells (MSCs).
Yunyuan Zhang, Xuran Jing, Zhongzhu Li, Qingwu Tian, Qing Wang, Xian Chen   +5 more
doaj   +1 more source

Exenatide Improves Bone Quality in a Murine Model of Genetically Inherited Type 2 Diabetes Mellitus [PDF]

, 2017
Type 2 diabetes mellitus (T2DM) is associated with skeletal complications, including an increased risk of fractures. Reduced blood supply and bone strength may contribute to this skeletal fragility.
Andreozzi, Anetzberger, Anichini, Aoyama, Baggio, Balint, Ban, Beckman, Bouxsein, Brunton, Chen, Coleman, Dempster, Ealey, Eckel, Feng, Flatt, Friedman, Griffith, Griffith, Hamilton, Hu, Karim, Kim, Lee, Lu, Ma, Mabilleau, Mabilleau, Mansur, Marenzana, Mieczkowska, Napoli, Nuche-Berenguer, Nuche-Berenguer, Nuche-Berenguer, Nystrom, Nystrom, Odgaard, Okerson, Orland, Orriss, Paschalis, Pereira, Pereira, Prisby, Richard, Roche, Roszer, Schalkwijk, Scheller, Selley, Shymkiw, Smits, Stabley, Sun, Tartaglia, Upadhyay, van Bloemendaal, Vijan, Williams, Wu, Yamamoto, Yamamoto, Yamamoto   +64 more
core   +6 more sources

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Low magnetic field promotes recombinant human BMP-2-induced bone formation and influences orientation of trabeculae and bone marrow-derived stromal cells

Bone Reports, 2021
Effects of high magnetic fields [MFs, ≥ 1 T (T)] on osteoblastic differentiation and the orientation of cells or matrix proteins have been reported. However, the effect of low MFs (< 1 T) on the orientation of bone formation is not well known. This study
Rintaro Okada, Kai Yamato, Minoru Kawakami, Joe Kodama, Junichi Kushioka, Daisuke Tateiwa, Yuichiro Ukon, Bal Zeynep, Takuya Ishimoto, Takayoshi Nakano, Hideki Yoshikawa, Takashi Kaito   +11 more
doaj   +1 more source

Runt-Related Transcription Factor 2 Induction During Differentiation of Wharton's Jelly Mesenchymal Stem Cells to Osteoblasts Is Regulated by Jumonji AT-Rich Interactive Domain 1B Histone Demethylase [PDF]

, 2017
Indexación: ScopusNovel bone regeneration approaches aim to obtain immature osteoblasts from somatic stem cells. Umbilical cord Wharton's jelly mesenchymal stem cells (WJ-MSCs) are an ideal source for cell therapy. Hence, the study of mechanisms involved
Amini, Baksh, Banerjee, Brydone, Burchell, Canha-Gouveia, Caplan, Carbonare, Cellot, Cho, Corotchi, Damme, Dey, Dignani, Dominici, Dull, Edwards, Fong, Frausin, Gauthaman, Geraerts, Grandy, Hassan, Hu, Huang, Hubble, Hung, Ji, Joerger-Messerli, Kalaszczynska, Karsenty, Kidder, Kim, Komori, Langenbach, Lee, Lee, Lee, Lian, Liu, Liu, Marolt, Marupanthorn, Maruyama, Mosna, Nekanti, Pittenger, Prieto, Reppel, Rocca, Rojas, Ryoo, Sarugaser, Sayegh, Schmitz, Sepulveda, Shibuya, Si, Soutoglou, Stanford, Stein, Tumber, Venugopal, Wang, Wang, Wang, Xie, Zhao   +67 more
core   +2 more sources

Extracellular vesicle microRNAs contribute to the osteogenic inhibition of mesenchymal stem cells in multiple myeloma [PDF]

, 2020
Osteolytic bone disease is the major complication associated with the progression of multiple myeloma (MM). Recently, extracellular vesicles (EVs) have emerged as mediators of MM-associated bone disease by inhibiting the osteogenic differentiation of ...
Alessandro R., Carlisi M., Conigliaro A., De Luca A., Giavaresi G., Lo Bosco G., Parisi S., Raimondi L., Raimondo S., Siragusa S., Urzi O.   +10 more
core   +1 more source

Gene regulatory landscape in osteoblast differentiation

Bone, 2020
The development of osteoblasts, a bone-forming cell population, occurs in conjunction with development of the skeleton, which creates our physical framework and shapes the body. In the past two decades, genetic studies have uncovered the molecular framework of this process-namely, transcriptional regulators and signaling pathways coordinate the cell ...
Hironori Hojo, Shinsuke Ohba
openaire   +2 more sources