Results 121 to 130 of about 31,358 (262)

ZMAT1 Promotes Osteoclastogenesis Through TRIM46 Mediated YAP1 Degradation and Inhibits Osteoblastogenesis

Advanced Science, EarlyView.
Zmat1 deficiency mitigates pathological bone loss by impairing osteoclastogenesis and promoting osteoblastogenesis. Mechanistically, in osteoclasts, Zmat1 loss relieves transcriptional repression of the E3 ligase TRIM46, promoting YAP1 degradation and inhibiting osteoclastogenic genes.
Xinyu Chang, Yijin Hou, Likun Cui, Huiqi Yu, Rong Liu, Junhao Sui, Zhong Zheng, Lu Liu, Jie Chen, Mengchen Chen, Chen Ding, Shuogui Xu, Sheng Xu, Hao Zhang   +13 more
wiley   +1 more source

Approaching Scarless Wound Healing: From Passive Anti‐Fibrotic to Proactive and Programmable Pro‐Regenerative Strategies

Advanced Science, EarlyView.
This review outlines the wound healing process and factors influencing scar formation, explores how certain animals and human fetuses achieve scarless skin or tissue regeneration, and details tissue engineering material strategies employed in scarless wound dressings.
Meimei Fu, Zhuoyi Huang, Jintao Li, Yue Li, Zhou Fang, Yiwen Jiang, Keke Wu, Jinshan Guo   +7 more
wiley   +1 more source

Development‐based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction

Advanced Science, EarlyView.
We present a development‐based in vivo bioreactor strategy to generate rejuvenated bone grafts (vBR‐Bone) within aged hosts. By enclosing vBR‐Bone fragments within an asymmetric biomimetic periosteum, segmental femoral defects in aged mice were successfully repaired within 6 weeks. Mechanistically, the multifactors of vBR‐Bone reconstitute a remodeling
Wenchao Zhang, Kai Dai, Tong Shen, Zehua Gao, Fengying Yan, Yuke Feng, Xuanlin Wang, Shaozhen Zhang, Jing Wang, Changsheng Liu   +9 more
wiley   +1 more source

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

Advanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin, Si‐ying He, Ting‐hui Xiao, Da‐mao Dai, Xin‐jia Hu, Nan Jiang   +5 more
wiley   +1 more source

Autophagy in osteoblasts is involved in mineralization and bone homeostasis

, 2015
Marie Nollet, Sabine Santucci‐Darmanin, Véronique Breuil, Rasha Al-Sahlanee, Chantal Cros, Majlinda Topi, David Momier, Michel Samson, Sophie Pagnotta, Laurence Cailleteau, Séverine Battaglia, Delphine Farlay, Romain Dacquin, Nicolas Barois, Pierre Jurdic, Georges Boivin, Dominique Heymann, Frank Lafont, Shi Shou Lu, David W. Dempster, Georges F. Carle, Valérie Pierrefite‐Carle   +21 more
openalex   +1 more source

The Topographic Effect of Zinc Oxide Nanoflowers on Osteoblast Growth and Osseointegration [PDF]

, 2010
Jung Kyu Park, Yong‐Jin Kim, Junseok Yeom, Ju Hyeong Jeon, Gyu‐Chul Yi, Jung Ho Je, Sei Kwang Hahn   +6 more
openalex   +1 more source

A LDH‐Based Supramolecular Photosensitizer‐Functionalized Bioactive Glass Scaffold for Integrated Postoperative Osteosarcoma Recurrence Prevention and Bone Regeneration

Advanced Science, EarlyView.
An intercalation assembly strategy is proposed to construct a novel LDH‐based supramolecular photosensitizer, which exhibits outstanding reactive oxygen species generation activity under 1270 nm laser irradiation. The deposition of supramolecular photosensitizer onto the surface of bioactive glass scaffolds results in the development of an innovative ...
Tao Wang, Yixin Bian, Tingting Hu, Mengyang Li, Yuqin Tan, Yu Yang, Xiaolan Jian, Xisheng Weng, Chaoliang Tan, Ruizheng Liang   +9 more
wiley   +1 more source

Osteoblast [PDF]

, 2018
openaire   +2 more sources

Supplementary Material for: Distinct Gene Expression Patterns Defining Human Osteoblasts' Response to BMP2 Treatment: Is the Therapeutic Success All a Matter of Timing?

, 2016
Sabrina Ehnert, Romina H. Aspera-Werz, Thomas Freude, Marie K. Reumann, Björn Gunnar Ochs, Christian Bahrs, Steffen Schröter, Elke Wintermeyer, Andreas K. Nüssler, Stefan Pscherer   +9 more
openalex   +1 more source

Regulation of Osteoblast Differentiation by Pasteurella Multocida Toxin (PMT): A Role for Rho GTPase in Bone Formation [PDF]

, 2004
Dympna Harmey, Gudrun Stenbeck, Catherine D. Nobes, Alistair J. Lax, Agamemnon E. Grigoriadis   +4 more
openalex   +1 more source