Results 141 to 150 of about 136,319 (308)
Advanced Science, EarlyView.Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv +13 more
wiley +1 more source
Evaluation of Propolis and Milk Administration on Caffein-Induced Mus musculus Fetus Skeletal
Pharmaceutical Sciences and Research, 2018 Caffeine consumption by pregnant women at doses above 300 mg/ day cause skeletal damage. One solution to protect skeletal damage is propolis, propolis contains flavonoids, which could increase the number of osteoblasts.
Dwisari Dillasamola +5 more
doaj
Advanced Science, EarlyView.A periosteum‐inspired Janus piezoelectric scaffold converts micromechanical forces into electrical signals and synergizes with controlled resveratrol release. This dual action reprograms endothelial metabolism, drives H‑type vessel formation, and restores bone–vessel coupling in diabetic bone defects.
Kai Wang, Kai Jiang
wiley +1 more source
, 2009 Introduction: The bone marrow microenvironment is further enriched by growth factors released during osteoclastic bone resorption. It has been reported that the chemokine interleukin (IL)-8 is a potent and direct activator of osteoclastic differentiation
FONG, YI-CHIN;MAA, MING-CHEI;TSAI, FUU- JEN;CHEN, WEN-CHI;LIN, JAUNG-GENG;JENG, LONG-BIN;YANG, RONG-SEN;FU, WEN-MEI;TANG, CHIH-HSIN +1 more
core
Paxillin expression and localization in osteoblasts.
, 2013 (A–C) Paxillin expression in MC3T3 osteoblasts, FAK+/+ osteoblasts and FAK−/− osteoblasts is similar. (D–F) Overlay of paxillin (red) and F-actin (green) as shown by phalloidin staining shows regions of strong paxillin expression and localization ...
Kristen L. Lee (306199) +10 more
core +1 more source
FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model
Advanced Science, EarlyView.FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble +9 more
wiley +1 more source
siRNA therapy in osteoarthritis: targeting cellular pathways for advanced treatment approaches
Frontiers in ImmunologyOsteoarthritis (OA) is a common joint disorder characterized by the degeneration of cartilage and inflammation, affecting millions worldwide. The disease’s complex pathogenesis involves various cell types, such as chondrocytes, synovial cells ...
Yunshen Li +9 more
doaj +1 more source
Biodegradable Zn‐Based Implants: Progress, Challenges, and Pathways toward Clinical Translation
Advanced Science, EarlyView.Exploring biodegradable Zn‐based implants offers a promising pathway to next‐generation biomedical devices with balanced degradation and biocompatibility. A comprehensive overview of biodegradable Zn‐based implants, covering their biological significance, material design principles, and advanced engineering strategies is provided.
Panfeng Zhao +10 more
wiley +1 more source
Advanced Science, EarlyView.This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun +14 more
wiley +1 more source
Gene-expression analysis of cementoblasts and osteoblasts.
, 2016 Cementum and bone are similar mineralized tissues, but cementum accumulates much more slowly than bone, does not have vasculature or innervation and does not undergo remodeling.
Roeder, E +18 more
core +1 more source