Results 121 to 130 of about 136,319 (308)
Verification of rat mandibular osteoblasts.
, 2014 A, Osteoblasts were cultured in DMEM containing 10% FCS for 14 days, then mineralized nodules were detected by Alizarin Red S staining. Immunocytochemical staining showed that the osteoblasts expressed ALP (B), Col-1 (C) and OCN (D). Scale bars represent
Wei Xiong (58411) +6 more
core +1 more source
A Three-Dimensional Dense Collagen Hydrogel to Model Cancer Cell/Osteoblast Interactions
Journal of Functional Biomaterials, 2018 No curative treatment options exist once breast cancer metastasizes to bone. This is due, in part, to an incomplete understanding of how osteolytic cancers interact with bone.
Mark James-Bhasin +2 more
doaj +1 more source
Advanced Science, EarlyView.Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen +8 more
wiley +1 more source
Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy
Advanced Science, EarlyView.Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang +5 more
wiley +1 more source
Confirmation of cell viability in hASCs and osteoblasts.
, 2018 (A) High mitochondrial membrane potential in hASCs. (B) High mitochondrial membrane potential in osteoblasts. (C) Cytochrome-c levels in hASCs. (D) Cytochrome-c levels in osteoblasts. (E) Autophagy levels in hASCs. (F) Autophagy levels in osteoblasts. (G)
Willian F. Zambuzzi (127932) +16 more
core +1 more source
Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair
Advanced Science, EarlyView.Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li +9 more
wiley +1 more source
, 2012 [[abstract]]Hepatocyte growth factor (HGF) has been demonstrated to stimulate osteoblast proliferation and participated bone remodeling. Bone morphogenetic protein-2 (BMP-2) is a crucial mediator in bone formation during fracture healing.
黃元勵;Huang, Yuan-Li
core
Viridicatol from the Deep‐Sea‐Derived Fungus Alleviates Bone Loss by Targeting the Wnt/SHN3 Pathway
Advanced ScienceAs an enticing bone anabolic target, short‐term inhibition of Schnurri‐3 (SHN3) resulted in high‐bone mass due to augmented osteoblast activity. However, no studies are conducted to identify natural products targeting SHN3 inhibition. Herein, a screening
Chun‐Lan Xie +10 more
doaj +1 more source
Advanced Science, EarlyView.Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu +7 more
wiley +1 more source
FGF and TGFbeta signalling in an in-vitro model of craniosynostosis
, 2009 Fibroblast Growth Factor (FGF) and Transforming Growth Factor beta (TGFbeta) are key regulators of bone development. Constitutively activating mutations of FGF Receptors (FGFR) 1-3 result in craniosynostosis, premature fusion of cranial sutures.
Lee, K.M.A.
core