Results 21 to 30 of about 222,196 (348)
Advanced Biomedical Research, 2012 Background: There are significant limitations in repair of irrecoverable bone defects. Stem-cell therapy is a promising approach for the construction of bone tissue.
Vahid Bahrambeigi +3 more
doaj +1 more source
Increased local bone turnover in patients with chronic periprosthetic joint infection
Bone & Joint Research, 2023 Aims: The management of periprosthetic joint infection (PJI) remains a major challenge in orthopaedic surgery. In this study, we aimed to characterize the local bone microstructure and metabolism in a clinical cohort of patients with chronic PJI ...
Nico Hinz +7 more
doaj +1 more source
Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces [PDF]
, 2015 The diverse composition and structure of extracellular matrix (ECM) interfaces encountered by tumor cells at secondary tissue sites can influence metastatic progression. Extensive in vitro and in vivo data has confirmed that metastasizing tumor cells can
Caley, Matthew P. +7 more
core +2 more sources
RAGE Signaling in Skeletal Biology [PDF]
, 2019 PURPOSE OF REVIEW: The receptor for advanced glycation end products (RAGE) and several of its ligands have been implicated in the onset and progression of pathologies associated with aging, chronic inflammation, and cellular stress. In particular, the
Davis, Hannah M. +2 more
core +2 more sources
Local origins impart conserved bone type-related differences in human osteoblast behaviour [PDF]
, 2015 Osteogenic behaviour of osteoblasts from trabecular, cortical and subchondral bone were examined to determine any bone type-selective differences in samples from both osteoarthritic (OA) and osteoporotic (OP) patients.
Clarkin, C E +6 more
core +3 more sources
Osteocytes as a record of bone formation dynamics: A mathematical model of osteocyte generation in bone matrix [PDF]
, 2014 The formation of new bone involves both the deposition of bone matrix, and the formation of a network of cells embedded within the bone matrix, called osteocytes.
Buenzli, Pascal R
core +3 more sources
Osteoblast–osteoclast interactions [PDF]
Connective Tissue Research, 2017 Bone homeostasis depends on the resorption of bones by osteoclasts and formation of bones by the osteoblasts. Imbalance of this tightly coupled process can cause diseases such as osteoporosis. Thus, the mechanisms that regulate communication between osteoclasts and osteoblasts are critical to bone cell biology.
Xiao, Chen +5 more
openaire +2 more sources
Carboxyl-modified single-wall carbon nanotubes improve bone tissue formation in vitro and repair in an in vivo rat model. [PDF]
, 2014 The clinical management of bone defects caused by trauma or nonunion fractures remains a challenge in orthopedic practice due to the poor integration and biocompatibility properties of the scaffold or implant material. In the current work, the osteogenic
Barrientos-Durán, Antonio +5 more
core +2 more sources
Biomolecules, 2020 Accumulating evidence demonstrates that the risk of osteoporotic fractures increases in patients with diabetes mellitus. Thus, diabetes-induced bone fragility has recently been recognized as a diabetic complication. As the fracture risk is independent of
Eun-Jung Lee +8 more
doaj +1 more source
MicroRNA-21: An Emerging Player in Bone Diseases
Frontiers in Pharmacology, 2021 MicroRNAs (MiRNAs) are small endogenous non-coding RNAs that bind to the 3′-untranslated region of target genes and promote their degradation or inhibit translation, thereby regulating gene expression. MiRNAs are ubiquitous in biology and are involved in
Chen Chen +6 more
doaj +1 more source