Results 1 to 10 of about 130,158 (334)

Osteoclasts and Microgravity [PDF]

Life, 2020
Astronauts are at risk of losing 1.0% to 1.5% of their bone mass for every month they spend in space despite their adherence to diets and exercise regimens designed to protect their musculoskeletal systems. This loss is the result of microgravity-related
John Kelly Smith
doaj   +5 more sources

Osteocyte-Driven Downregulation of Snail Restrains Effects of Drd2 Inhibitors on Mammary Tumor Cells [PDF]

, 2018
While bone is a frequent target of breast cancer-associated metastasis, little is known about the effects of tumor-bone interactions on the efficacy of tumor-suppressing agents.
Chen, Andy, Fan, Yao, Jalali, Aydin, Li, Bai-Yan, Liu, Shengzhi, Minami, Kazumasa, Nakshatri, Harikrishna, Ogawa, Kazuhiko, Yokota, Hiroki   +8 more
core   +1 more source

IgSF11-mediated phosphorylation of pyruvate kinase M2 regulates osteoclast differentiation and prevents pathological bone loss

Bone Research, 2023
Osteoclasts are primary bone-resorbing cells, and receptor-activated NF-kB ligand (RANKL) stimulation is the key driver of osteoclast differentiation.
Hyunsoo Kim, Noriko Takegahara, Yongwon Choi   +2 more
doaj   +1 more source

The unbearable lightness of bone marrow homeostasis [PDF]

, 2015
The anatomical and functional dimensions of bone marrow topography have been at the forefront of modern bone and immunological research for many years and remain a source of complexity and perplexity due to the multitude of microhabitats within this ...
AGAS, DIMITRIOS, Douni E., MARCHETTI, Luigi, SABBIETI, Maria Giovanna   +3 more
core   +1 more source

Electron Microscopic Studying of Rat Bone Cells Under Microgravity Conditions [PDF]

, 2016
In the experiments on rats (SLS-2) with the use of electron microscopy there was made the study of the osteoclasts population and the peculiarities of resorptive processes in a spongy bone of the epiphyses and the iliac crest.The results of investigation
Polkovenko, O. (Olga)
core   +2 more sources

Recruitment, augmentation and apoptosis of rat osteoclasts in 1,25-(OH)2D3 response to short-term treatment with 1,25-dihydroxyvitamin D3in vivo [PDF]

, 2002
Background Although much is known about the regulation of osteoclast (OC) formation and activity, little is known about OC senescence. In particular, the fate of of OC seen after 1,25-(OH)2D3 administration in vivo is unclear.
A Jäger, A Kahn, B Riggs, C Dijkstra, D Fischman, D Hughes, F Solari, G Hattersley, G Hattersley, G Roodman, G Vaes, H Uy, I McLean, J Bollerslev, J Feyen, J Gram, J Merke, J Owens, J Zerwekh, JC Gallagher, JG Damoiseaux, JJ Reynolds, M Holtrop, N Athanasou, N Udagawa, P Bianco, P Geusens, P Hauschka, P McSheehy, R Beelen, R Boyce, R Felix, R Felix, R Kitazawa, RG Erben, S Manolagas, S Marks, S Mori, S Ott, S Tinkler, T Murakami, T Sminia, T Suda, T Suda, W Bourque, Y Kobayashi, Y Tanaka   +46 more
core   +4 more sources

IL-17A deficiency inhibits lung cancer-induced osteoclastogenesis by promoting apoptosis of osteoclast precursor cells.

PLoS ONE
Osteoclasts are crucial in the events leading to bone metastasis of lung cancer. Interleukin-17A (IL-17A) affects osteogenesis by regulating the survival of osteoclast precursors (OCPs) and is enriched in lung cancer cells.
Hongkai Wang, Hao Tang, Shujie Yuan, Chuntao Liang, Yuanxin Li, Shida Zhu, Kai Chen   +6 more
doaj   +1 more source

Nrf2 is required for suppressing osteoclast RANKL-induced differentiation in RAW 264.7 cells via inactivating cannabinoid receptor type 2 with AM630

Regenerative Therapy, 2020
Objective: Nuclear factor-erythroid 2-related factor 2 (Nrf2) is shown to as a negative-regulatory cause in osteoclasts differentiation. Cannabinoid receptor type 2 (CB2) is verified to regulate osteoclast differentiation, though with diversed results ...
Wan Li, Yongxin Sun
doaj  

Calcium phosphate-based materials regulate osteoclast-mediated osseointegration

Bioactive Materials, 2021
Calcium phosphate-based materials (CaP) have been widely used as bone graft substitutes with a decent osseointegration. However, the mechanism whereby cells function and repair the bone defect in CaP micro-environment is still elusive.
Xiaogang Wang, Yuanman Yu, Luli Ji, Zhen Geng, Jing Wang, Changsheng Liu   +5 more
doaj  

Osteoclast-Derived Extracellular Vesicles: Novel Regulators of Osteoclastogenesis and Osteoclast–Osteoblasts Communication in Bone Remodeling

Frontiers in Physiology, 2018
Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, play an important role in cellular communication during skeletal growth and homeostasis.
Feng-Lai Yuan, Qian-yuan Wu, Zong-Ning Miao, Ming-Hui Xu, Rui-Sheng Xu, Dong-Lin Jiang, Jun-Xing Ye, Fei-hu Chen, Ming-Dong Zhao, Hao-jue Wang, Xia Li   +10 more
doaj   +1 more source