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Osteoclasts and Microgravity [PDF]

Life, 2020
Astronauts are at risk of losing 1.0% to 1.5% of their bone mass for every month they spend in space despite their adherence to diets and exercise regimens designed to protect their musculoskeletal systems. This loss is the result of microgravity-related
John Kelly Smith
doaj   +5 more sources

Interleukin-32 promotes osteoclast differentiation but not osteoclast activation.

PLoS ONE, 2009
BackgroundInterleukin-32 (IL-32) is a newly described cytokine produced after stimulation by IL-2 or IL-18 and IFN-gamma. IL-32 has the typical properties of a pro-inflammatory mediator and although its role in rheumatoid arthritis has been recently ...
Guillaume Mabilleau, Afsie Sabokbar
doaj   +3 more sources

Accelerated Lactate Dehydrogenase Activity Potentiates Osteoclastogenesis via NFATc1 Signaling. [PDF]

PLoS ONE, 2016
Osteoclasts seem to be metabolic active during their differentiation and bone-resorptive activation. However, the functional role of lactate dehydrogenase (LDH), a tetrameric enzyme consisting of an A and/or B subunit that catalyzes interconversion of ...
Heejin Ahn, Kyunghee Lee, Jin Man Kim, So Hyun Kwon, Seoung Hoon Lee, Soo Young Lee, Daewon Jeong   +6 more
doaj   +1 more source

Ceritinib (LDK378) prevents bone loss via suppressing Akt and NF-κB-induced osteoclast formation

Frontiers in Endocrinology, 2022
BackgroundCeritinib is used for the treatment of patients with anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC), who are at the risk of developing bone metastasis.
Wenxin He, Wenxin He, Wenxin He, Xiankun Cao, Keyu Kong, Kewei Rong, Shuai Han, An Qin   +7 more
doaj   +1 more source

CYP27A1 deficiency promoted osteoclast differentiation [PDF]

PeerJ, 2023
Background The elevating osteoclast differentiation can lead to an imbalance in bone homeostasis, which was responsible for bone loss and bone diseases, such as osteoporosis. Multiple pathways and molecules have been involved in osteoclast formation, but
Ziqi Fang, Guangdong Cheng, Mengting He, Yanliang Lin   +3 more
doaj   +2 more sources

Mechanical stimulation controls osteoclast function through the regulation of Ca2+-activated Cl− channel Anoctamin 1

Communications Biology, 2023
Mechanical force loading is essential for maintaining bone homeostasis, and unloading exposure can lead to bone loss. Osteoclasts are the only bone resorbing cells and play a crucial role in bone remodeling. The molecular mechanisms underlying mechanical
Weijia Sun, Yuheng Li, Jianwei Li, Yingjun Tan, Xinxin Yuan, Haoye Meng, Jianting Ye, Guohui Zhong, XiaoYan Jin, Zizhong Liu, Ruikai Du, Wenjuan Xing, Dingsheng Zhao, Jinping Song, Youyou Li, Junjie Pan, Yunzhang Zhao, Qi Li, Aiyuan Wang, Shukuan Ling, Rongji Dai, Yingxian Li   +21 more
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Vitamin Regulation of Osteoclast Differentiation

Central Asian Journal of Medical Sciences, 2020
Objectives: Vitamins play critical roles in cellular metabolism, growth, and many enzymatic processes of the human body. They are also crucial in signal transduction and transcription pathways of many processes, including osteoclast differentiation. This
Erdenezaya Odkhuu, Shijir Narmandakh, Munkhjargal Zinamyadar, Juramt Bold, Avirmed Amgalanbaatar, Enebish Sundui   +5 more
doaj   +1 more source

Surface proteins of Propionibacterium freudenreichii MJ2 inhibit RANKL-induced osteoclast differentiation by lipocalin-2 upregulation and lipocalin-2-mediated NFATc1 inhibition

Scientific Reports, 2023
Osteoclasts degrade bone and osteoclast differentiation has been implicated in bone destruction in rheumatoid arthritis. The dairy bacterium Propionibacterium freudenreichii MJ2 (MJ2) isolated from raw milk inhibits osteoclast differentiation and ...
Jiah Yeom, Seongho Ma, Dong Joon Yim, Young-Hee Lim   +3 more
doaj   +1 more source

Origin of Osteoclasts: Osteoclast Precursor Cells

Journal of Bone Metabolism, 2023
Osteoclasts are multinucleated bone-resorbing cells and a key player in bone remodeling for health and disease. Since the discovery of osteoclasts in 1873, the structure and function of osteoclasts and the molecular and cellular mechanisms of osteoclastogenesis have been extensively studied.
Jefferson Tsai, Kaichi Kaneko, Andrew J. Suh, Richard Bockman, Kyung-Hyun Park-Min   +4 more
openaire   +2 more sources

Complex dynamics of osteoclast formation and death in long-term cultures. [PDF]

PLoS ONE, 2008
BACKGROUND: Osteoclasts, cells responsible for bone resorption, contribute to the development of degenerative, metabolic and neoplastic bone diseases, which are often characterized by persistent changes in bone microenvironment.
Timur Akchurin, Tayeb Aissiou, Naomi Kemeny, Erin Prosk, Nilima Nigam, Svetlana V Komarova   +5 more
doaj   +1 more source