Results 1 to 10 of about 182,622 (382)

Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

Nature Communications, 2016
Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs (miRNAs) have a crucial role in regulating osteoclast and osteoblast function.
Defang Li, Jin Liu, Baosheng Guo, Chao Liang, Lei Dang, Cheng Lu, Xiaojuan He, Hilda Yeuk-Siu Cheung, Liang Xu, Changwei Lu, Bing He, Biao Liu, Atik Badshah Shaikh, Fangfei Li, Luyao Wang, Zhijun Yang, Doris Wai-Ting Au, Songlin Peng, Zongkang Zhang, Bao-Ting Zhang, Xiaohua Pan, Airong Qian, Peng Shang, Lianbo Xiao, Baohong Jiang, Chris Kong-Chu Wong, Jiake Xu, Zhaoxiang Bian, Zicai Liang, De-an Guo, Hailong Zhu, Weihong Tan, Aiping Lu, Ge Zhang   +33 more
doaj   +2 more sources

Osteoclast-Derived Extracellular Vesicles: Novel Regulators of Osteoclastogenesis and Osteoclast–Osteoblasts Communication in Bone Remodeling

Frontiers in Physiology, 2018
Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, play an important role in cellular communication during skeletal growth and homeostasis.
Feng-Lai Yuan, Qian-yuan Wu, Zong-Ning Miao, Ming-Hui Xu, Rui-Sheng Xu, Dong-Lin Jiang, Jun-Xing Ye, Fei-hu Chen, Ming-Dong Zhao, Hao-jue Wang, Xia Li   +10 more
doaj   +2 more sources

A Novel Role of Protecadherin-7 in Regulation of Pydc3 Expression and the IFN-β Response During Osteoclast Differentiation [PDF]

Cells
Protocadherin-7 (Pcdh7) is a member of the protocadherin family, a subgroup of the cadherin superfamily. We previously demonstrated that Pcdh7 functions as a signaling receptor in osteoclast differentiation.
Hyunsoo Kim, Noriko Takegahara, Yongwon Choi   +2 more
doaj   +2 more sources

The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation [PDF]

, 2010
Background: Clock genes and their protein products regulate circadian rhythms in mammals but have also been implicated in various physiological processes, including bone formation.
AE Hoffman, AM Parfitt, Arndt F. Schilling, AV Neutzsky-Wulff, B Zheng, CA Feillet, CJ Rosen, DA Corral, Dong-Yan Jin, E Grundberg, Erik Maronde, G Hampp, Gijsbertus van der Horst, GT van der Horst, H Oster, H Viswambharan, Isabelle Schmutz, J Liu, JM Gimble, K Bae, K Henriksen, K Shidara, L Fu, L Fu, LP Shearman, M Amling, M Merrow, M Rucinski, M Zaidi, MH Hastings, Michael Amling, R Dallmann, R Spanagel, S Sato, S Stephan, S Vaira, S Yoo, S Zvonic, Sebastian Seitz, SM Reppert, Thorsten Schinke, U Albrecht, Urs Albrecht, V Pilorz, X Wu, X Wu, X Wu   +46 more
core   +13 more sources

Accelerated Lactate Dehydrogenase Activity Potentiates Osteoclastogenesis via NFATc1 Signaling. [PDF]

PLoS ONE, 2016
Osteoclasts seem to be metabolic active during their differentiation and bone-resorptive activation. However, the functional role of lactate dehydrogenase (LDH), a tetrameric enzyme consisting of an A and/or B subunit that catalyzes interconversion of ...
Heejin Ahn, Kyunghee Lee, Jin Man Kim, So Hyun Kwon, Seoung Hoon Lee, Soo Young Lee, Daewon Jeong   +6 more
doaj   +1 more source

CYP27A1 deficiency promoted osteoclast differentiation [PDF]

PeerJ, 2023
Background The elevating osteoclast differentiation can lead to an imbalance in bone homeostasis, which was responsible for bone loss and bone diseases, such as osteoporosis. Multiple pathways and molecules have been involved in osteoclast formation, but
Ziqi Fang, Guangdong Cheng, Mengting He, Yanliang Lin   +3 more
doaj   +2 more sources

Ceritinib (LDK378) prevents bone loss via suppressing Akt and NF-κB-induced osteoclast formation

Frontiers in Endocrinology, 2022
BackgroundCeritinib is used for the treatment of patients with anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC), who are at the risk of developing bone metastasis.
Wenxin He, Wenxin He, Wenxin He, Xiankun Cao, Keyu Kong, Kewei Rong, Shuai Han, An Qin   +7 more
doaj   +1 more source

Mechanical stimulation controls osteoclast function through the regulation of Ca2+-activated Cl− channel Anoctamin 1

Communications Biology, 2023
Mechanical force loading is essential for maintaining bone homeostasis, and unloading exposure can lead to bone loss. Osteoclasts are the only bone resorbing cells and play a crucial role in bone remodeling. The molecular mechanisms underlying mechanical
Weijia Sun, Yuheng Li, Jianwei Li, Yingjun Tan, Xinxin Yuan, Haoye Meng, Jianting Ye, Guohui Zhong, XiaoYan Jin, Zizhong Liu, Ruikai Du, Wenjuan Xing, Dingsheng Zhao, Jinping Song, Youyou Li, Junjie Pan, Yunzhang Zhao, Qi Li, Aiyuan Wang, Shukuan Ling, Rongji Dai, Yingxian Li   +21 more
doaj   +1 more source

The Macrophage-Osteoclast Axis in Osteoimmunity and Osteo-Related Diseases

Frontiers in Immunology, 2021
Osteoimmunity is involved in regulating the balance of bone remodeling and resorption, and is essential for maintaining normal bone morphology. The interaction between immune cells and osteoclasts in the bone marrow or joint cavity is the basis of ...
Yao Yao, Xiaoyu Cai, Fu-jia Ren, Yiqing Ye, Fengmei Wang, Caihong Zheng, Ying Qian, Meng Zhang   +7 more
semanticscholar   +1 more source

Vitamin Regulation of Osteoclast Differentiation

Central Asian Journal of Medical Sciences, 2020
Objectives: Vitamins play critical roles in cellular metabolism, growth, and many enzymatic processes of the human body. They are also crucial in signal transduction and transcription pathways of many processes, including osteoclast differentiation. This
Erdenezaya Odkhuu, Shijir Narmandakh, Munkhjargal Zinamyadar, Juramt Bold, Avirmed Amgalanbaatar, Enebish Sundui   +5 more
doaj   +1 more source