Results 111 to 120 of about 87,738 (302)

Spatio-temporal structure of cell distribution in cortical Bone Multicellular Units: a mathematical model

, 2010
Bone remodelling maintains the functionality of skeletal tissue by locally coordinating bone-resorbing cells (osteoclasts) and bone-forming cells (osteoblasts) in the form of Bone Multicellular Units (BMUs). Understanding the emergence of such structured
Bird, Bronckers, Buenzli, Burger, D.W. Smith, Evans, Frost, Frost, Gori, Halmos, Harada, Iqbal, Ishii, Ishii, Jaworski, Jaworski, Komarova, Lauffenburger, Lemaire, Martin, Martin, P. Pivonka, P.R. Buenzli, Parfitt, Parfitt, Parfitt, Pivonka, Roodman, Ryser, Ryser, Scheurer, Tang, Thomas, van Oers, Väänänen, Wolfram Research   +35 more
core   +2 more sources

Protocatechuic acid inhibits osteoclast differentiation and stimulates apoptosis in mature osteoclasts

Biomedicine & Pharmacotherapy, 2016
Imbalance in bone remodeling causes osteoporosis.In the present study, we identified that protocatechuic acid inhibits osteoclast differentiation and induces apoptosis in RAW264.7 murine macrophage cells.Tartrate-resistance acid phosphatase (TRAP) activity was used to determine osteoclast formation.
Yi-Xin, Wu, Tong-Yu, Wu, Bin-Bin, Xu, Xiao-Yan, Xu, Hong-Gan, Chen, Xi-Yao, Li, Guilong, Wang   +6 more
openaire   +2 more sources

Peptide Receptor‐Functionalized AuNP‐Embedded Zwitterionic Biopolymeric Nanohydrogel for Electrochemical Sclerostin Sensing

Advanced Science, EarlyView.
We report an electrochemical biosensor that employs biopanning‐derived affinity peptides as selective receptors on a multifunctional chitosan–zwitterionic–gold nanoparticle (CS–ZI–AuNPs) nanohydrogel interface. The CS–ZI–AuNPs nanohydrogel exhibits antifouling properties, abundant sites for stable peptide immobilization, and efficient electrochemical ...
Hyo Jeong Yang, Jae Hwan Shin, Mingi Jo, Changyeon Lee, Hyunmin Yi, Al‐Montaser Bellah H. Ali, Jong Pil Park   +6 more
wiley   +1 more source

Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin‐Mediated NRF2 Degradation

Advanced Science, EarlyView.
Lipid metabolic stress triggers ferroptosis in PDLSCs through the GSK3β/NRF2 pathway, thereby aggravating periodontal bone loss. Upregulated GSK3β promotes NRF2 ubiquitination and proteasomal degradation via β‐TrCP, suppressing NRF2 nuclear translocation and antioxidant target expression.
Yuxiao Zhang, Xiangyao Wang, Yaxin Wu, Liping Liu, Gaoshaer Nuerlan, Ahsawle Ozathaley, Xiaorui Zhang, Jinping Wang, Bowen Yang, Jing Mao, Yan Liu, Shiqiang Gong   +11 more
wiley   +1 more source

TRPA1 aggravates osteoclastogenesis and osteoporosis through activating endoplasmic reticulum stress mediated by SRXN1

Cell Death and Disease
Osteoporosis (OP) is a disorder of bone remodeling caused by an imbalance between bone resorption by osteoclasts and bone formation by osteoblasts. Therefore, inhibiting excessive osteoclast activity is one of the promising strategies for treating OP.
Pengfei Zhu, Huaqiang Tao, Kai Chen, Miao Chu, Qiufei Wang, Xing Yang, Jun Zhou, Huilin Yang, Dechun Geng   +8 more
doaj   +1 more source

Moderate excess of pyruvate augments osteoclastogenesis

Biology Open, 2013
Summary Cell differentiation leads to adaptive changes in energy metabolism. Conversely, hyperglycemia induces malfunction of many body systems, including bone, suggesting that energy metabolism reciprocally affects cell differentiation.
Jenna E. Fong, Damien Le Nihouannen, Kerstin Tiedemann, Gulzhakhan Sadvakassova, Jake E. Barralet, Svetlana V. Komarova   +5 more
doaj   +1 more source

Mangiferin positively regulates osteoblast differentiation and suppresses osteoclast differentiation

Molecular Medicine Reports, 2017
Mangiferin is a polyphenolic compound present in Salacia reticulata. It has been reported to reduce bone destruction and inhibit osteoclastic differentiation. This study aimed to determine whether mangiferin directly affects osteoblast and osteoclast proliferation and differentiation, and gene expression in MC3T3‑E1 osteoblastic cells and osteoclast ...
Sekiguchi, Yuusuke, Mano, Hiroshi, Nakatani, Sachie, Shimizu, Jun, Kataoka, Aya, Ogura, Kana, Kimira, Yoshifumi, Ebata, Midori, Wada, Masahiro   +8 more
openaire   +3 more sources

Bamboo‐Like Whiskers‐Reinforced Bioceramics Accelerate Large Segmental Bone Regeneration via Dual Modulation of Type‐H Vessels and Osteoinduction

Advanced Science, EarlyView.
The graphical abstract image of bamboo‐like whisker‐reinforced Ca‐P bioceramics accelerating large segmental bone regeneration. ABSTRACT Regenerative repair of segmental bone defect remains a major clinical challenge. The conventional mental implants suffer from mechanical strength mismatch and long‐term foreign bodies presence.
Cong Feng, Haibo Teng, Chuyao Xu, Jiaze He, Keting Liu, Xueying Li, Kai Zhang, Xiangdong Zhu, Xiangfeng Li, Jianguo Xu, Xingdong Zhang   +10 more
wiley   +1 more source

Canonical Wnt Signaling in Differentiated Osteoblasts Controls Osteoclast Differentiation

Developmental Cell, 2005
Inactivation of beta-catenin in mesenchymal progenitors prevents osteoblast differentiation; inactivation of Lrp5, a gene encoding a likely Wnt coreceptor, results in low bone mass (osteopenia) by decreasing bone formation. These observations indicate that Wnt signaling controls osteoblast differentiation and suggest that it may regulate bone formation
Glass, D.A., Bialek, P., Ahn, J.D., Starbuck, M., Patel, M.S., Clevers, J.C., Taketo, M.M., Long, F., McMahon, A.P., Lang, R.A., Karsenty, G.   +10 more
openaire   +3 more sources

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source