Results 111 to 120 of about 8,722 (259)

Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity [PDF]

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis, which is characterized by increased bone resorption and inadequate bone formation.
Madsen, K., Hansen, Morten, Omata, Yasunori, Zaiss, M.M., Hansen, Morten Svarer, Gorvin, Caroline, Zaiss, Mario M., Madsen, Kaja, Hansen, Morten S.; id_orcid, Søe, K., Frost, Morten, Søe, Kent, Rauch, Alexander, Rauch, A., Hansen, Morten S., Hansen, M.S., Frost, M., Gorvin, C.M., Omata, Y., Gorvin, Caroline M; id_orcid, Madsen, Kaja; id_orcid, Gorvin, Caroline M., Price, Maria; id_orcid, Price, M., Zaiss, Mario, Frost, Morten; id_orcid, Price, Maria, Søe, Kent; id_orcid, Soe, Kent   +28 more
core   +1 more source

Role of cell-matrix interactions in osteoclast differentiation [PDF]

, 2007
Osteoclast and their mononuclear cell precursors are present within the bone microenvironment at sites of physiologic and pathologic bone resorption. Analysis of tissues from sites of bone resorption reveal that cells expressing the full morphological ...
Flannery, M., Zhenxin Shen, Crotti, T., Shen, Z., M. R. Flannery, Tania Crotti, Steven R. Goldring, Goldring, S., Roberto Jose Fajardo, McHugh, K., Fajardo, R., Benjamin E. Bierbaum, Bierbeum, B., Kevin P. McHugh   +13 more
core   +1 more source

Hells protects mitochondrial integrity via Nr2f2 suppression during osteoclast differentiation

Cell Communication and Signaling
Background Osteoclasts are specialized bone-resorbing cells essential for skeletal homeostasis. While chromatin remodelers play critical roles in gene regulation, their specific contributions to osteoclastogenesis remain largely unexplored. In particular,
Myoung Jun Kim, Sung Kyung Choi, Bitnuri Yu, Minho Kim, Un Yung Choi, Sunsook Hwang, Wahn Soo Choi, Jueng Soo You   +7 more
doaj   +1 more source

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

Advanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma, Lucinda A. E. Evans, Lucie E. Bourne, Jishizhan Chen, Alissa L. Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter D. Lee, Katherine A. Staines   +10 more
wiley   +1 more source

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

c-fos Antisense DNA Inhibits Proliferation of Osteoclast Progenitors in Osteoclast Developments but not Macrophage Differentiation In Vitro [PDF]

, 1996
We previously reported that osteoclast formation in vitro, by coculture of mouse bone marrow and primary osteoblastic cells, occurs in two phases: proliferation of osteoclast progenitors followed by terminal differentiation into mature osteoclasts. Using
Findlay, D., Wada, S., Udagawa, N., Chan, J.   +3 more
core   +1 more source

Moderate excess of pyruvate augments osteoclastogenesis

Biology Open, 2013
Summary Cell differentiation leads to adaptive changes in energy metabolism. Conversely, hyperglycemia induces malfunction of many body systems, including bone, suggesting that energy metabolism reciprocally affects cell differentiation.
Jenna E. Fong, Damien Le Nihouannen, Kerstin Tiedemann, Gulzhakhan Sadvakassova, Jake E. Barralet, Svetlana V. Komarova   +5 more
doaj   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

The potentiating effects of cell stress upon osteoclast differentiation [PDF]

, 2017
Osteoclast formation is a highly regulated multi-step process, which involves the differentiation of haemopoietic progenitor cells into mature, active osteoclasts.
Van der Kraan, A. Gabrielle Josephine (3806335)
core   +1 more source

Role of soft tissue and bone interactions in the developmental integration and modularity of the skull in neural crest‐specific gap junction alpha‐1 knockout mice

The Anatomical Record, EarlyView.
Abstract The vertebrate skull is composed of bones derived from neural crest cells and mesoderm. The evolutionary capacity of the skull has been linked, in part, to the emergence of neural crest cells; however, this increased capacity for evolutionary change requires that variation within neural crest‐ and mesoderm‐derived bones remains partly ...
Alyssa C. Moore, Madeline Tourigny, Diana Quinonez, Kevin Barr, Matthew W. Grol, Katherine E. Willmore   +5 more
wiley   +1 more source