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Osteocytes and Diabetes: Altered Function of Diabetic Osteocytes
Current Osteoporosis Reports, 2020Diabetes mellitus is a prevalent chronic disease affecting millions of people in the world. Bone fragility is a complication found in diabetic patients. Although osteoblasts and osteoclasts are directly affected by diabetes, herein we focus on how the diabetic state-based on hyperglycemia and accumulation of advanced glycation end products among other ...
Arancha R. Gortázar, Juan A. Ardura
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Archives of Biochemistry and Biophysics, 2008
The osteocyte resides in the lacuna/canalicular system in bone and has been hypothesized to orchestrate local bone remodeling. Certainly the identification of the osteocyte as the source of Sclerostin, a molecule that regulates osteoblast function, has supported this possibility.
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The osteocyte resides in the lacuna/canalicular system in bone and has been hypothesized to orchestrate local bone remodeling. Certainly the identification of the osteocyte as the source of Sclerostin, a molecule that regulates osteoblast function, has supported this possibility.
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Isolation of fossil osteocytes
Journal of the Royal Microscopical Society, 1965During routine maceration of shales for the extraction of fossil spores, a number of unusual structures appeared which were eventually identified as osteocytes from scales belonging to a palaeoniscid, a primitive bony fish. No vertebrate tissues had been expected, since the technique employed destroys virtually all substances with the exception of ...
R, NEVES, L B, TARLO
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Current Osteoporosis Reports, 2003
The osteocyte is the most abundant cell type of bone. There are approximately 10 times as many osteocytes as osteoblasts in adult human bone, and the number of osteoclasts is only a fraction of the number of osteoblasts. Our current knowledge of the role of osteocytes in bone metabolism is far behind our insight into the properties and functions of the
Klein Nulend, J. +2 more
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The osteocyte is the most abundant cell type of bone. There are approximately 10 times as many osteocytes as osteoblasts in adult human bone, and the number of osteoclasts is only a fraction of the number of osteoblasts. Our current knowledge of the role of osteocytes in bone metabolism is far behind our insight into the properties and functions of the
Klein Nulend, J. +2 more
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The Journal of Bone & Joint Surgery, 1960
Counts of the percentage of empty osteocyte lacunae were done on fresh, undecalcified bone sections of specimens from forty-five human subjects ranging in age from new-born infancy to eighty-four years. The average figures from arbitrary age groups suggest that an increasing percentage of bone dies with increasing age.
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Counts of the percentage of empty osteocyte lacunae were done on fresh, undecalcified bone sections of specimens from forty-five human subjects ranging in age from new-born infancy to eighty-four years. The average figures from arbitrary age groups suggest that an increasing percentage of bone dies with increasing age.
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