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Current Osteoporosis Reports, 2021 While the function of osteocytes under physiologic conditions is well defined, their role and involvement in cancer disease remains relatively unexplored, especially in a context of non-bone metastatic cancer. This review will focus on describing the more advanced knowledge regarding the interactions between osteocytes and cancer.We will discuss the ...
Matt Prideaux +2 more
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Mechanosensation and transduction in osteocytes [PDF]
Bone, 2013 The human skeleton is a miracle of engineering, combining both toughness and light weight. It does so because bones possess cellular mechanisms wherein external mechanical loads are sensed.
Rommel G Bacabac +2 more
exaly +2 more sources
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The International Journal of Biochemistry & Cell Biology, 2004
Osteocytes are the most numerous cells in mature bone and have the potential to live as long as the organism itself. However, study and subsequent understanding of osteocyte biology has been thwarted by the remote location of the cell in the mineralized matrix.
Melissa L, Knothe Tate +3 more
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Osteocytes are the most numerous cells in mature bone and have the potential to live as long as the organism itself. However, study and subsequent understanding of osteocyte biology has been thwarted by the remote location of the cell in the mineralized matrix.
Melissa L, Knothe Tate +3 more
openaire +2 more sources
Osteocytes and Diabetes: Altered Function of Diabetic Osteocytes
Current Osteoporosis Reports, 2020Diabetes mellitus is a prevalent chronic disease affecting millions of people in the world. Bone fragility is a complication found in diabetic patients. Although osteoblasts and osteoclasts are directly affected by diabetes, herein we focus on how the diabetic state-based on hyperglycemia and accumulation of advanced glycation end products among other ...
Arancha R. Gortázar, Juan A. Ardura
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Zeitschrift fur Orthopadie und Unfallchirurgie, 2019
For a long time, osteocytes were regarded as passive bystanders of bone metabolism. Bone remodeling was considered to be an interplay between bone forming osteoblasts and bone degrading osteoclasts. However, the dogma of osteocytes as bystanders within the bone has changed fundamentally since the turn of the millenium.
Markus, Rupp +5 more
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For a long time, osteocytes were regarded as passive bystanders of bone metabolism. Bone remodeling was considered to be an interplay between bone forming osteoblasts and bone degrading osteoclasts. However, the dogma of osteocytes as bystanders within the bone has changed fundamentally since the turn of the millenium.
Markus, Rupp +5 more
openaire +2 more sources
Current Osteoporosis Reports, 2007
Osteocytes, the most abundant cell type in bone, remain the least characterized. Several theories have been proposed regarding their function, including osteolysis, sensing the strains produced in response to mechanical loading of bones, and producing signals that affect the function of osteoblasts and osteoclasts and hence, bone turnover.
Giolanta, Kogianni, Brendon S, Noble
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Osteocytes, the most abundant cell type in bone, remain the least characterized. Several theories have been proposed regarding their function, including osteolysis, sensing the strains produced in response to mechanical loading of bones, and producing signals that affect the function of osteoblasts and osteoclasts and hence, bone turnover.
Giolanta, Kogianni, Brendon S, Noble
openaire +2 more sources
Archives of Biochemistry and Biophysics, 2008
The osteocyte resides in the lacuna/canalicular system in bone and has been hypothesized to orchestrate local bone remodeling. Certainly the identification of the osteocyte as the source of Sclerostin, a molecule that regulates osteoblast function, has supported this possibility.
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The osteocyte resides in the lacuna/canalicular system in bone and has been hypothesized to orchestrate local bone remodeling. Certainly the identification of the osteocyte as the source of Sclerostin, a molecule that regulates osteoblast function, has supported this possibility.
openaire +2 more sources
FGF23 production by osteocytes [PDF]
Pediatric Nephrology, 2012 Fibroblast growth factor 23 (FGF23), a known regulator of phosphate homeostasis, is produced by cells residing in bone, namely, osteocytes, to target a distant organ, the kidney. Elevated FGF23 levels have recently been found systemically and in osteocytes in patients and animal models of chronic kidney disease.
Michael Wacker +2 more
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Isolation of fossil osteocytes
Journal of the Royal Microscopical Society, 1965During routine maceration of shales for the extraction of fossil spores, a number of unusual structures appeared which were eventually identified as osteocytes from scales belonging to a palaeoniscid, a primitive bony fish. No vertebrate tissues had been expected, since the technique employed destroys virtually all substances with the exception of ...
R, NEVES, L B, TARLO
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