Results 71 to 80 of about 31,786 (255)

A Dual‐Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor‐Associated Osteolysis Restoration via Sequential Release

Advanced Science, EarlyView.
The versatile CaO2@CuMOF@HAP nanohybrid demonstrates an outstanding MMP9/pH‐triggered release performance for sequential release of osteogenic growth peptide into deep‐seated tumor‐infiltrated bone destruction areas and dual ions into tumor cells, enabling efficient tumor‐associated osteolysis restoration and tumor elimination for more comprehensive ...
Lan Liu, Han‐Zhe Liu, Zhe‐Nan Liu, Tong Wang, Li‐Li Yu, Qiu‐Jing Li, Zi‐Yi Chen, Guo‐Feng Luo, Zheng‐Jun Shang   +8 more
wiley   +1 more source

Beyond Transconductance: Cell‐Polymer Coupling Determines Fidelity in Action Potential Recording via Electrolyte‐Gated Polymer Transistors

Advanced Science, EarlyView.
High electrical performance alone does not guarantee efficient bioelectronic signal transduction. Despite excellent mixed ionic‐electronic conduction, recordings from cardiomyocytes reveal that p(g2T‐TT)‐based OECTs predominantly transduce field potential FP‐like signals due to weak cell‐polymer coupling.
Giulia Zoe Zemignani, Elena Mancinelli, Gabriele Tullii, Aleksandr Khudiakov, Cristiano Bortolotti, Shubham Tanwar, Peter J. Schwartz, Luca Sala, Maria Rosa Antognazza, Mario Caironi, Adrica Kyndiah   +10 more
wiley   +1 more source

Cortical Bone Loss and Fragility in a 2-Month Triple Transgenic Mouse Model of Alzheimer’s Disease

Cells
Alzheimer’s disease (AD) and osteoporosis frequently co-occur in the elderly; however, the pathophysiological link between these two diseases remains unclear.
Giuseppina Storlino, Francesca Posa, Teresa Stefania Dell'Endice, Federica Piccolo, Graziana Colaianni, Tommaso Cassano, Maria Grano, Giorgio Mori   +7 more
doaj   +1 more source

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu, Yang Liu, Kang Kang, Jianfeng Yu, Xiaowei Xia, Yaoge Deng, Yingjie Lu, Huilin Yang, Lisong Li, Wu Xu, Yijian Zhang, Xuesong Zhu   +11 more
wiley   +1 more source

ZMAT1 Promotes Osteoclastogenesis Through TRIM46 Mediated YAP1 Degradation and Inhibits Osteoblastogenesis

Advanced Science, EarlyView.
Zmat1 deficiency mitigates pathological bone loss by impairing osteoclastogenesis and promoting osteoblastogenesis. Mechanistically, in osteoclasts, Zmat1 loss relieves transcriptional repression of the E3 ligase TRIM46, promoting YAP1 degradation and inhibiting osteoclastogenic genes.
Xinyu Chang, Yijin Hou, Likun Cui, Huiqi Yu, Rong Liu, Junhao Sui, Zhong Zheng, Lu Liu, Jie Chen, Mengchen Chen, Chen Ding, Shuogui Xu, Sheng Xu, Hao Zhang   +13 more
wiley   +1 more source

Peptide Receptor‐Functionalized AuNP‐Embedded Zwitterionic Biopolymeric Nanohydrogel for Electrochemical Sclerostin Sensing

Advanced Science, EarlyView.
We report an electrochemical biosensor that employs biopanning‐derived affinity peptides as selective receptors on a multifunctional chitosan–zwitterionic–gold nanoparticle (CS–ZI–AuNPs) nanohydrogel interface. The CS–ZI–AuNPs nanohydrogel exhibits antifouling properties, abundant sites for stable peptide immobilization, and efficient electrochemical ...
Hyo Jeong Yang, Jae Hwan Shin, Mingi Jo, Changyeon Lee, Hyunmin Yi, Al‐Montaser Bellah H. Ali, Jong Pil Park   +6 more
wiley   +1 more source

miR-29b-3p regulated osteoblast differentiation via regulating IGF-1 secretion of mechanically stimulated osteocytes

Cellular & Molecular Biology Letters, 2019
Background Mechanical loading is an essential factor for bone formation. A previous study indicated that mechanical tensile strain of 2500 microstrain (με) at 0.5 Hz for 8 h promoted osteogenesis and corresponding mechanoresponsive microRNAs (miRs) were ...
Qiangcheng Zeng, Yang Wang, Jie Gao, Zhixiong Yan, Zhenghua Li, Xianqiong Zou, Yanan Li, Jiahui Wang, Yong Guo   +8 more
doaj   +1 more source

Correlations Between Osteocyte Lacuno‐Canalicular Network and Material Characteristics in Healthy and Mechanically Stimulated Murine Tibiae

Advanced NanoBiomed Research, EarlyView.
This article reveals how calcium content, mineral nanostructure, and lacuno‐canalicular network (LCN) organization interact to shape bone heterogeneity in mouse tibiae. Advanced multimodal imaging uncovers that mechanical loading promotes mature mineral structures even in low‐calcium regions, highlighting LCN‐driven mineralization and offering new ...
Victoria Schemenz, Maximilian Rummler, Alexander van Tol, Isabela Vitienes, Tobias Thiele, Markus A. Hartmann, Manfred Burghammer, Peter Fratzl, Richard Weinkamer, Bettina M. Willie, Wolfgang Wagermaier   +10 more
wiley   +1 more source

A proximodistal gradient in bone structure and mechanics in the wings of Seba's short‐tailed bat, Carollia perspicillata

The Anatomical Record, EarlyView.
Abstract Bats possess the remarkable ability to fly, and with this, distinctive wing bone properties. We investigated the structural, mechanical, and compositional properties of the humerus, radius, metacarpals, and proximal and middle phalanges of Carollia perspicillata, an approximately 15 g fruit‐eating bat native to the Neotropics.
Xiaoxiang Ma, Aowen Deng, Sabah Nobakhti, Sharon Swartz, Sandra J. Shefelbine   +4 more
wiley   +1 more source

Evaluation of IHH, PTCH1, and SMO protein immunohistochemistry in the human mandibular condyle at fetal stages from 30 to 80 mm greatest length

The Anatomical Record, EarlyView.
Abstract This study evaluated the morphogenesis of the temporomandibular joint (TMJ) in human fetuses during the third month of gestation through the analysis of immunohistochemistry for the proteins Indian Hedgehog (IHH), Patched‐1 (PTCH1), and Smoothened (SMO).
Filipe Santos da Silva, Carolina de Oliveira Gigek, Andreia Fabiana Do Vale Franco, Amanda Alves Ribeiro Massoni, José Ramon Mérida‐Velasco, Luís Otávio Carvalho de Moraes   +5 more
wiley   +1 more source