Results 51 to 60 of about 2,318 (174)

Loss of Dkk-1 in Osteocytes Mitigates Alveolar Bone Loss in Mice With Periodontitis

Frontiers in Immunology, 2019
Background: Periodontitis is a highly prevalent infection-triggered inflammatory disease that results in bone loss. Inflammation causes bone resorption by osteoclasts, and also by suppression of bone formation via increase of Dickkopf-1 (Dkk-1), an ...
Paula Goes, Paula Goes, Caio Dutra, Caio Dutra, Lennart Lösser, Lorenz C. Hofbauer, Martina Rauner, Sylvia Thiele   +7 more
doaj   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, Volume 13, Issue 49, 3 September 2026.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Phenotyping of Human Pulp Cells After Cryopreservation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 18, September 2026.
ABSTRACT This study aimed to compare cell viability, morphology, cell yield, and stem cell‐associated marker expression of cryopreserved human dental pulp cells (HDPCs) across different passages following thawing and serial in vitro expansion. HDPCs were isolated from three healthy donors, cryopreserved at −80°C for 3 months, and subsequently evaluated
Camila Maura Morais Lima dos Santos, Washington Henrique Themoteo da Silva, Fernanda Rodrigues Guedes, Milla Christian de Paula, Leslie Morse, Ricardo Battaglino, Marcelo José Barbosa Silva, Ana Paula Turrioni   +7 more
wiley   +1 more source

Immune Modulation by Transplanted Calcium Phosphate Biomaterials and Human Mesenchymal Stromal Cells in Bone Regeneration

Frontiers in Immunology, 2019
A wide variety of biomaterials have been developed as both stabilizing structures for the injured bone and inducers of bone neoformation. They differ in chemical composition, shape, porosity, and mechanical properties.
Paul Humbert, Meadhbh Á. Brennan, Meadhbh Á. Brennan, Noel Davison, Noel Davison, Philippe Rosset, Philippe Rosset, Valérie Trichet, Frédéric Blanchard, Pierre Layrolle   +9 more
doaj   +1 more source

A Dual‐Bioresponsive and Programmable Microneedle Matrix as a Bioinspired Coupler for Orchestrating Diabetic Bone Regeneration

Advanced Materials, Volume 38, Issue 42, 27 July 2026.
This project developed a smart bandage‐like patch (a microneedle array) for repairing diabetic bone damage. It intelligently senses signals from infection and inflammation, then releases its medicines in a specific, timed sequence: first an antibacterial agent, then an anti‐inflammatory agent, and finally growth factors.
Yu Wang, Rui Chen, Yu Chen, Haowen Lu, Yuchen Qian, Zhiheng Gao, Zheming Shen, Xiaofei Zheng, Huilin Yang, Jun Zou, Yusen Qiao   +10 more
wiley   +1 more source

Osteoimmunology in rheumatic diseases [PDF]

Arthritis Research & Therapy, 2009
This review summarizes the recent advances of osteoimmunology, a new research field that investigates the interaction of the immune system with the skeleton. Osteoimmunology has contributed significantly to the understanding of joint destruction in rheumatoid arthritis and other forms of arthropathies.
openaire   +2 more sources

A New Stage and Classification of Osteonecrosis of the Femoral Head Based on MRI With Pathophysiological Interpretation

Orthopaedic Surgery, Volume 18, Issue 7, Page 1448-1458, July 2026.
An MRI‐based classification system integrating fibrosis extent (F1–F3) and inflammatory bone marrow edema activity (E0–E3) was developed for osteonecrosis of the femoral head (ONFH). Increasing fibrosis and edema severity were associated with higher collapse risk, worse pain, and poorer hip function.
Mengran Shen, Hongxu Li, Haoyang Liu, Qihan Ma, Bailiang Wang, Liming Cheng, Jinhui Ma   +6 more
wiley   +1 more source

Osteoimmunology – A review

IP International Journal of Periodontology and Implantology, 2020
Periodontitis is a pathological disorder that involves inflammation of the periodontium and this occurs as a response to various pathogens. The immune complex or the host defense system comprises of host responses that aim at blocking the invading pathogens that cause periodontal diseases.
Amreen Ara, Uma Sudhakar, Nimisha Mithradas   +2 more
openaire   +2 more sources

Senescent BMSC‐Derived Thbs1 Drives Inflammaging and Impairs Bone Regeneration by Suppressing PINK1/Parkin‐Mediated Mitophagy in Macrophages

Aging Cell, Volume 25, Issue 6, June 2026.
Aging BMSC‐derived Thbs1 activates the macrophage TGF‐β/Smad3 pathway to transcriptionally repress Pink1, impairing mitophagy and causing mitochondrial ROS accumulation. This redox imbalance drives M1 polarization and IL‐6 secretion. IL‐6 feeds back to BMSCs via the JAK/STAT3 pathway to inhibit osteogenesis and upregulate Thbs1, establishing a self ...
Yifeng Xing, Jingjing Su, Yanjun Lin, Nengwen Huang, Sihui Zhang, Yuwei Zhou, Jie Lu, Weiping Chen, Kaixun He, Wenxiu Yuan, Yang Li, Geyuan Zheng, Pengyuan Hu, Dong Wu, Yanjing Ou, Jiang Chen   +15 more
wiley   +1 more source

Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling

Journal of Periodontal Research, Volume 61, Issue 6, Page 662-694, June 2026.
Periodontitis can be viewed as a state of inflammatory uncoupling of bone remodeling, in which excessive osteoclast‐mediated resorption coexists with impaired bone formation. This review integrates emerging insights from osteoimmunology, osteocyte biology, mechanobiology, aging, and resolution pathways to position periodontitis as an accessible in vivo
Rafael Scaf de Molon, Sotirios Tetradis, Rolando Vernal, Fabio Renato Manzolli Leite, Thomas E. Van Dyke   +4 more
wiley   +1 more source