Results 81 to 90 of about 913,373 (166)

2116 Exploring Müller cell-cone interactions in human fovea using 3-dimensional volume electron microscopy (EM)

Journal of Clinical and Translational Science, 2018
OBJECTIVES/SPECIFIC AIMS: Müller cells, radial glial cells of the retina, are the principal repository of xanthophyll pigment (lutein, zeaxanthin, meso-zeaxanthin), which are modifiable by diet and visible clinically by autofluorescence imaging.
Ramya Singireddy, Kenneth R. Sloan, Jeff W. Lichtman, Christine A. Curcio, Dennis M. Dacey   +4 more
doaj   +1 more source

Understanding extracellular vesicle biology, isolation, and characterization: The theory of EV‐erything

Periodontology 2000, EarlyView.
Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad, Nima Farshidfar, Nathan E. Estrin, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +6 more
wiley   +1 more source

Spatiotemporal pattern of doublecortin expression in the retina of the sea lamprey

Frontiers in Neuroanatomy, 2016
Despite the importance of doublecortin (DCX) for the development of the nervous system, its expression in the retina of most vertebrates is still unknown.
Blanca eFernández-López, Daniel eRomaus-Sanjurjo, Pablo eSenra-Martínez, Ramón eAnadón, Antón eBarreiro-Iglesias, María Celina eRodicio   +5 more
doaj   +1 more source

Schwann Cell‐Specific ATG7‐Dependent Autophagy Protects Myelin in a Mouse Model of Krabbe Disease

Glia, Volume 74, Issue 12, December 2026.
Krabbe disease (KD) is caused by mutations in GALC and deregulated lysosomal function in Schwann cells (SCs). Using a SC‐specific Galc‐cKO mouse, we identified altered autophagy in SCs during KD progression. Further ablation of Atg7 in SCs of KD worsened disease severity.
Narayan Dhimal, Aditya Sidharth, Jiajun Zhang, Trina Rudra, Edward Hurley, Pablo M. Paez, Fraser J. Sim, Daesung Shin, M. Laura Feltri   +8 more
wiley   +1 more source

Radial glia regulate vascular patterning around the developing spinal cord

, 2017
Vascular networks surrounding individual organs are important for their development, maintenance, and function; however, how these networks are assembled remains poorly understood.
Matsuoka, Ryota L., Marass, Michele, Stainier, Didier Y.R., Lawson, Nathan D., Avdesh, Avdesh, Maischein, Hans-Martin, Herzog, Wiebke, Helker, Christian S.M., Grosse, Ann S., Kaur, Harmandeep   +9 more
core   +1 more source

Spatially Self‐Organized Three‐Dimensional Neural Concentroid as a Novel Reductionist Humanized Model to Study Neurovascular Development

Advanced Science
Although human pluripotent stem cell (PSC)‐derived brain organoids have enabled researchers to gain insight into human brain development and disease, these organoids contain solely ectodermal cells and are not vascularized as occurs during brain ...
Yoke Chin Chai, San Kit To, Susan Simorgh, Samantha Zaunz, YingLi Zhu, Karan Ahuja, Alix Lemaitre, Roya Ramezankhani, Bernard K. van derVeer, Keimpe Wierda, Stefaan Verhulst, Leo A. vanGrunsven, Vincent Pasque, Catherine Verfaillie   +13 more
doaj   +1 more source

Cell cycle-dependent cues regulate temporal patterning of the Drosophila central brain neural stem cells

eLife
During nervous system development, diverse types of neurons and glia are sequentially generated by self-renewing neural stem cells (NSCs). Temporal changes in gene expression within NSCs are thought to regulate neural diversity; however, the mechanisms ...
Gonzalo N Morales Chaya, Mubarak Hussain Syed   +1 more
doaj   +1 more source

Radial outer retina reflectivity (RORR) sign in LAMP2‐associated retinopathy

Acta Ophthalmologica, Volume 104, Issue 8, Page e960-e972, December 2026.
Abstract Purpose To describe the radial outer retina reflectivity (RORR) sign in patients carrying pathogenic variants in the X‐linked lysosome‐associated membrane protein‐2 (LAMP2) gene and to review the histologic characteristics of LAMP2 expression in the human retina.
Rachael C. Heath Jeffery, Bohdan Kousal, Ulrike Grünert, Christine A. Curcio, Svetlana Cherepanoff, Tina M. Lamey, Michel Michaelides, Chrysanthi Tsika, Isabelle Chow, Omar A. Mahroo, Seungmin Lee, Martin Meliska, Milos Kubanek, Jakub Sikora, Siying Lin, Raymond C. B. Wong, Petra Liskova, Fred K. Chen   +17 more
wiley   +1 more source

TGF-β1 PROMOTES CEREBRAL CORTEX RADIAL GLIA-ASTROCYTE DIFFERENTIATION IN VIVO [PDF]

, 2014
The major neural stem cell population in the developing cerebral cortex is composed of the radial glial cells, which generate glial cells and neurons.
Rômulo Sperduto Dezonne, Daniel Francis, Ana Paula Bérgamo de Araújo, Flavia Carvalho Alcantara Gomes, Flávia Carvalho Alcantara Gomes, Daniel Francis Franco, Ana Paula eBérgamo, Carolina A. Moraes, Rômulo Sperdutto Dezonne, Joice eStipursky, Lays eSouza, Lays Souza, Carolina eMoraes, Joice Stipursky   +13 more
core   +1 more source

Lis1 mutation prevents basal radial glia-like cell production in the mouse

, 2021
International audienceAbstract Human cerebral cortical malformations are associated with progenitor proliferation and neuronal migration abnormalities. Progenitor cells include apical radial glia, intermediate progenitors and basal (or outer) radial glia
Belvindrah, Richard, Wang, Shengming, Jin, Mingyue, Penisson, Maxime, Francis, Fiona, Hirotsune, Shinji, Shengming Wang, Fiona Francis, Mingyue Jin, Richard Belvindrah, Shinji Hirotsune, Maxime Penisson   +11 more
core   +1 more source