Results 61 to 70 of about 913,373 (166)

AKAP1 Protects Retinal Ganglion Cells and Preserves Vision by Improving Mitochondrial and Synaptic Health in Glaucomatous Neurodegeneration

Advanced Science, EarlyView.
Intravitreal AAV2‐mediated AKAP1 restoration enhances mitochondrial fusion and biogenesis, improves bioenergetic capacity, and preserves mitochondrial integrity in glaucomatous RGCs. AKAP1 stabilizes presynaptic structure, maintaining synaptic protein expression, and limiting complement‐associated neuroinflammation.
Tonking Bastola, Keun‐Young Kim, Ziyao Shen, Guy A. Perkins, Muna Poudel, Yoonjin Lim, Hyejeong Choi, Soo‐Ho Choi, Mark H. Ellisman, Robert N. Weinreb, Won‐Kyu Ju   +10 more
wiley   +1 more source

Radial glia and somal translocation of radial neurons in the developing cerebral cortex

, 2003
A series of recent studies have demonstrated that radial glia are neural precursors in the developing cerebral cortex. These studies have further implied that these cells are the sole precursor constituents of the dorsal forebrain ventricular zone that ...
Ravishankar, Bagirathy, Nadarajah, Bagirathy, Bagirathy Nadarajah   +2 more
core   +1 more source

Bacillus Licheniformis‐Induced Cognitive Decline in Mice Linking Gut Microbiota Dysbiosis, Metabolic Perturbations, and Hippocampal Neuroinflammation

Advanced Science, EarlyView.
Chronic oral administration of specific probiotic strains triggers gut microbiota dysbiosis and systemic metabolic perturbations in mice. Multi‐omics profiling reveals subsequent hippocampal glial remodeling and neuroinflammation, which are linked to cognitive impairment.
Yibin Lin, Afeng Wang, Hongchang Zhou, Yuliang Sun, Yingying Guo, Keyu Chen, Junhong Sun, Tinliang Lin, Zhaochen Huang, Xinhua Qiang, Jie He, Jianlin Lou, Yunliang Yao, Shengwen Shao, Yongliang Pan, Xiang Wang   +15 more
wiley   +1 more source

ATRX is required for maintenance of the neuroprogenitor cell pool in the embryonic mouse brain

Biology Open, 2014
Mutations in the alpha-thalassemia mental retardation X-linked (ATRX) gene cause a spectrum of abnormalities including intellectual disability, developmental delay, seizures, and microcephaly.
Kieran Ritchie, L. Ashley Watson, Benjamin Davidson, Yan Jiang, Nathalie G. Bérubé   +4 more
doaj   +1 more source

Ocular morphology and morphometry of the great egret (Ardea alba): A comprehensive anatomical description

The Anatomical Record, EarlyView.
Abstract Ardea alba (Linnaeus, 1758) is widely distributed, yet knowledge of its ocular morphology remains limited. This study described the morphometry and morphology of the eyeball and its accessory glands in six specimens using radiography, morphometry, light and scanning electron microscopy, and 3D scanning.
Julia Vaz Feio, Max Alex Santos Ferreira, Iara Fernanda Lima do Espírito Santo, Elane Guerreiro Giese, Érika Branco, Antônio Basílio Guerreiro Junior, Ana Rita de Lima   +6 more
wiley   +1 more source

Brain organoid models of SZT2-related disease reveal an overproduction of outer radial glial cells through mTORC1 activation

Scientific Reports
Biallelic loss-of-function variants of Seizure Threshold 2 (SZT2) cause neurodevelopmental diseases with developmental delay, epilepsy, and macrocephaly.
Emi Sato, Yuji Nakamura, Masanori Fujimoto, Issei S. Shimada, Toshihiko Iwaki, Daisuke Ieda, Yutaka Negishi, Ayako Hattori, Yoichi Kato, Shinji Saitoh   +9 more
doaj   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Extracellular Control of Radial Glia Proliferation and Scaffolding During Cortical Development and Pathology

Frontiers in Cell and Developmental Biology, 2020
During the development of the cortex, newly generated neurons migrate long-distances in the expanding tissue to reach their final positions. Pyramidal neurons are produced from dorsal progenitors, e.g., radial glia (RGs) in the ventricular zone, and then
Julien Ferent, Julien Ferent, Julien Ferent, Donia Zaidi, Donia Zaidi, Donia Zaidi, Fiona Francis, Fiona Francis, Fiona Francis   +8 more
doaj   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Calcium Signaling in the Cerebellar Radial Glia and Its Association with Morphological Changes during Zebrafish Development

, 2021
Radial glial cells are a distinct non-neuronal cell type that, during development, span the entire width of the brain walls of the ventricular system. They play a central role in the origin and placement of neurons, since their processes form structural ...
Angeles Edith Espino-Saldaña, Elizabeth Pereida-Jaramillo, Gabriela B. Gómez-González, Ataúlfo Martínez-Torres   +3 more
core   +1 more source