Results 71 to 80 of about 913,373 (166)

A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble, Samantha L. Payne, Matthew K. Vickaryous   +2 more
wiley   +1 more source

Radial Glial Cells Are They Really Glia?

, 2001
During the development of the cerebral cortex, radial glia serve as a scaffold to support and direct neurons during their migration. This view is now changing in the light of emerging evidence showing that these cells have a much more dynamic and diverse
Nadarajah, Bagirathy, Parnavelas, John G.   +1 more
core   +2 more sources

Generation of human cerebral organoids with a structured outer subventricular zone

Cell Reports
Summary: Outer radial glia (oRG) emerge as cortical progenitor cells that support the development of an enlarged outer subventricular zone (oSVZ) and the expansion of the neocortex.
Ryan M. Walsh, Raffaele Luongo, Elisa Giacomelli, Gabriele Ciceri, Chelsea Rittenhouse, Antonietta Verrillo, Maura Galimberti, Vittoria Dickinson Bocchi, Youjun Wu, Nan Xu, Simone Mosole, James Muller, Elena Vezzoli, Johannes Jungverdorben, Ting Zhou, Roger A. Barker, Elena Cattaneo, Lorenz Studer, Arianna Baggiolini   +18 more
doaj   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Neurotrophic extracellular matrix proteins promote neuronal and iPSC astrocyte progenitor cell‐ and nano‐scale process extension for neural repair applications

Journal of Anatomy, Volume 246, Issue 4, Page 585-601, April 2025.
The extracellular matrix plays a critical role in modulating cell behaviour in the central nervous system influencing neural cell morphology and growth. However, a better understanding of the impact of individual matrix proteins on both neurons and astrocytes is critical for advancing the development of matrix‐based neural repair strategies.
Cian O'Connor, Rena E. Mullally, Sarah F. McComish, Julia O'Sullivan, Ian Woods, Ingmar Schoen, Massimiliano Garre, Maeve A. Caldwell, Adrian Dervan, Fergal J. O'Brien   +9 more
wiley   +1 more source

Identity and nature of neural stem cells in the adult human subventricular zone

iScience
Summary: The existence of neural stem cells (NSCs) in adult human brain neurogenic regions remains unresolved. To address this, we created a cell atlas of the adult human subventricular zone (SVZ) derived from fresh neurosurgical samples using single ...
Salma Baig, Javad Nadaf, Redouane Allache, Phuong U. Le, Michael Luo, Annisa Djedid, Andriniaina Nkili-Meyong, Maryam Safisamghabadi, Alex Prat, Jack Antel, Marie-Christine Guiot, Kevin Petrecca   +11 more
doaj   +1 more source

The MacBrain Resource Center (MBRC) rhesus macaque embryonic brain histology datasets

Journal of Anatomy, EarlyView.
We introduce the MacBrain Resource Center (MBRC) Collections of rhesus macaque embryonic brain tissue. Here, we illustrate histo‐ and immunohistology from our dynamically growing Collection 6, which currently contains >10,000 zoomable and downloadable images from n = 14 male and female embryos from early to late in gestation.
Valeria Mendoza‐Silva, Emma Burke, Lucy Greene, Mikhail Rodov, Janja Kopić, Phil Barello, Yury M. Morozov, Keiko Moriya‐Ito, Chiaki Ohtaka‐Maruyama, Zeljka Krsnik, Pasko Rakic, Alvaro Duque   +11 more
wiley   +1 more source

Radial glia inhibit peripheral glial infiltration into the spinal cord at motor exit point transition zones [PDF]

, 2016
In the mature vertebrate nervous system, central and peripheral nervous system (CNS and PNS, respectively) GLIA myelinate distinct motor axon domains at the motor exit point transition zone (MEP TZ).
Johnson, Kimberly, Welsh, Taylor G., Michael J. F. Barresi, Cody J. Smith, Kimberly Johnson, Kucenas, Sarah, Sarah Kucenas, Taylor G. Welsh, Barresi, Michael J.F., Smith, Cody J.   +9 more
core   +1 more source

Expression of the neurodevelopmental disease susceptibility genes CADM1 and CADM2 in the early human fetal forebrain

Journal of Anatomy, EarlyView.
CADM1 and CADM2 are related cell‐adhesion molecules that show differential patterns of expression in early human fetal forebrain. Although often co‐expressed in neurons, CADM2 protein exclusively and selectively localises to axons, whereas CADM1 is predominantly expressed in the nucleus, posing questions as to what their developmental roles might be ...
Natalie Wucherer, Maznah Alhesain, Amn Ashhad, Marc Woodbury‐Smith, Gavin J. Clowry   +4 more
wiley   +1 more source

Neuronal or glial progeny: Regional differences in radial glia fate

, 2003
The precursor function of the ubiquitous glial cell type in the developing central nervous system (CNS), the radial glia, is largely unknown. Using Cre/IoxP in vivo fate mapping studies, we found that radial glia generate virtually all cortical ...
GOTZ M., Hack, M.A., Götz, M., Kirchhoff, F., KIRCHHOFF F, KLINKERT W, Goetz, M., Hartfuss, E., Klinkert, W., HACK MA, KETTENMANN H, Hack, M., Kettenmann, H., Malatesta, P., HARTFUSS E, MALATESTA, PAOLO   +15 more
core   +1 more source