Results 51 to 60 of about 913,373 (166)

Catalpol promotes the generation of cerebral organoids with oRGs through activation of STAT3 signaling

Bioengineering & Translational Medicine
The generation of human cortical organoids containing outer radial glia (oRG) cells is crucial for modeling neocortical development. Here we show that Catalpol, an iridoid glucoside derived from Rehmannia glutinosa, significantly enhances the generation ...
Yoo‐Jung Lee, Byounggook Cho, Daeyeol Kwon, Yunkyung Kim, Saemin An, Soi Kang, Jongpil Kim   +6 more
doaj   +1 more source

Control of Outer Radial Glial Stem Cell Mitosis in the Human Brain

Cell Reports, 2014
Evolutionary expansion of the human neocortex is partially attributed to a relative abundance of neural stem cells in the fetal brain called outer radial glia (oRG).
Bridget E.L. Ostrem, Jan H. Lui, Caitlyn C. Gertz, Arnold R. Kriegstein   +3 more
doaj   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV

Advanced Science, EarlyView.
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu   +7 more
wiley   +1 more source

Investigating radial glia in vitro

, 2007
During mammalian neurogenesis newly born neurons migrate radially along the extended bipolar process of cells termed radial glia. Our views of radial glia as a 'static' support/guide cell have changed over recent years.
S. M. Pollard, L. Conti
core   +1 more source

Molecular Fate Determinants in Embryonic and Adult Neural Stem Cells [PDF]

, 2005
The molecular signals specifying neuronal, glial or multipotent precursors in the developing and adult central nervous system (CNS) are largely unknown. Radial glial cells have recently been discovered as major precursor population generating neurons or ...
Hack, M.A., Hack, Michael Anton
core   +1 more source

Temporal transcriptomic dynamics in developing macaque neocortex

eLife
Despite intense research on mice, the transcriptional regulation of neocortical neurogenesis remains limited in humans and non-human primates. Cortical development in rhesus macaque is known to recapitulate multiple facets of cortical development in ...
Longjiang Xu, Zan Yuan, Jiafeng Zhou, Yuan Zhao, Wei Liu, Shuaiyao Lu, Zhanlong He, Boqin Qiang, Pengcheng Shu, Yang Chen, Xiaozhong Peng   +10 more
doaj   +1 more source

Distinct Vulnerability and Resilience of Human Neuroprogenitor Subtypes in Cerebral Organoid Model of Prenatal Hypoxic Injury

Frontiers in Cellular Neuroscience, 2019
Prenatal hypoxic injury (HI) is a leading cause of neurological disability. The immediate and long-term effects of hypoxia on progenitor homeostasis and developmental progression during early human brain development remain unclear.
Nicolas Daviaud, Clément Chevalier, Roland H. Friedel, Roland H. Friedel, Hongyan Zou, Hongyan Zou   +5 more
doaj   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Radial glia: Multi-purpose cells for vertebrate brain development

, 2002
Radial glia are specialized cells in the developing nervous system of all vertebrates, and are characterized by long radial processes. These processes facilitate the best known function of radial glia: guiding the radial migration of newborn neurons from
Götz, M., Campbell, K., Kenneth Campbell, Magdalena Götz   +3 more
core   +1 more source