Multicenter evaluation of ceftazidime-avibactam use in carbapenem-resistant Klebsiella pneumoniae bloodstream infections in OXA-48 endemic regions [PDF]
Scientific ReportsData in the literature on the use of ceftazidime-avibactam (CAZ-AVI) in carbapenem-resistant Klebsiella pneumoniae bloodstream infections (CRKP-BSIs) are limited especially in OXA-48 (Oxacillinase-48) predominant regions.
Ali Mert +16 more
doaj +2 more sources
Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48 [PDF]
ACS Infectious Diseases, 2021 Despite the advances in β-lactamase inhibitor development, limited options exist for the class D carbapenemase known as OXA-48. OXA-48 is one of the most prevalent carbapenemases in carbapenem-resistant Enterobacteriaceae infections and is not susceptible to most available β-lactamase inhibitors. Here, we screened various low-molecular-weight compounds
Doris Mia Taylor +8 more
openaire +3 more sources
Spread of the blaOXA-48/IncL Plasmid within and between Dogs in City Parks, France
Microbiology Spectrum, 2022 The blaOXA-48/IncL plasmid is increasingly reported in dogs, even in the absence of carbapenem use in animals. In this study, we witnessed the spread of this plasmid within and between dogs sharing the same relaxing area.
Marisa Haenni +4 more
doaj +1 more source
OXA-48-like carbapenemases: the phantom menace [PDF]
Journal of Antimicrobial Chemotherapy, 2012 OXA-48-type carbapenem-hydrolysing class D β-lactamases are increasingly reported in enterobacterial species. To date, six OXA-48-like variants have been identified, with OXA-48 being the most widespread. They differ by a few amino acid substitutions or deletions (one to five amino acids).
Laurent, Poirel +2 more
openaire +2 more sources
Comparative evaluation of a novel chromogenic medium (chromID OXA-48) for detection of OXA-48 producing Enterobacteriaceae [PDF]
Diagnostic Microbiology and Infectious Disease, 2013 Comparative evaluation of the recently developed chromogenic culture medium chromID OXA-48 (bioMérieux) with chromID CARBA (bioMérieux) and SUPERCARBA showed that chromID OXA-48 and SUPERCARBA media have the highest sensitivity for detection of OXA-48 producing Enterobacteriaceae (91% and 93%) comparatively to chromID CARBA (21 %).
Girlich, Delphine +3 more
openaire +2 more sources
Treatment of Infections by OXA-48-Producing Enterobacteriaceae [PDF]
Antimicrobial Agents and Chemotherapy, 2018 Carbapenemase-producing Enterobacteriaceae (CPE) contribute significantly to the global public health threat of antimicrobial resistance. OXA-48 and its variants are unique carbapenemases with low-level hydrolytic activity toward carbapenems but no intrinsic activity against expanded-spectrum cephalosporins.
Adam Stewart +3 more
openaire +3 more sources
The Global Ascendency of OXA-48-Type Carbapenemases [PDF]
Clinical Microbiology Reviews, 2019 Surveillance studies have shown that OXA-48-like carbapenemases are the most common carbapenemases in Enterobacterales in certain regions of the world and are being introduced on a regular basis into regions of nonendemicity, where they are responsible for nosocomial outbreaks. OXA-48, OXA-181, OXA-232, OXA-204, OXA-
Johann D. D. Pitout +4 more
openaire +2 more sources
Discovery of bla(OXA-199), a chromosome-based bla(OXA-48)-like variant, in Shewanella xiamenensis. [PDF]
PLoS ONE, 2012 INTRODUCTION: bla(OXA-48) is a globally emerging carbapenemase-encoding gene. The progenitor of bla(OXA-48) appears to be a Shewanella species. The presence of the bla(OXA-48)-like gene was investigated for two Shewanella xiamenensis strains.
Zhiyong Zong
doaj +1 more source
Evaluation of a New Phenotypic OXA-48 Disk Test for Differentiation of OXA-48 Carbapenemase-Producing Enterobacteriaceae Clinical Isolates [PDF]
Journal of Clinical Microbiology, 2015 ABSTRACT The current phenotypic methods for detecting carbapenemase-producing Enterobacteriaceae (CPE) allow differentiation between class A and B carbapenemases, but they cannot confirm in a single test class D OXA-48 carbapenemase producers.
Tsakris, A. +5 more
openaire +3 more sources
Characterization of OXA-48-producing Klebsiella oxytoca isolates from a hospital outbreak in Tunisia
Journal of Global Antimicrobial Resistance, 2021 Objective: There is very limited information about OXA-48-producing Klebsiella oxytoca. The aim of this study was to describe the phenotypic and molecular characterization of OXA-48-producing K.
Julia Guzmán-Puche +7 more
doaj +1 more source