Results 21 to 30 of about 23,173 (138)
Journal of Global Infectious Diseases, 2016 Carbapenemase producing Gram-negative pathogen is of great concern for physician. The challenging aspects are treatment option and infection control.
Yamuna Devi Bakthavatchalam +2 more
doaj +1 more source
One-Step Differential Detection of OXA-48-Like Variants Using High-Resolution Melting (HRM) Analysis
Antibiotics, 2020 OXA-48-like carbapenemase gene remains a hidden threat, as different OXA-48 variants have varying presentations of susceptibility to antibiotics that might affect the treatment decisions.
Min Yi Lau +6 more
doaj +1 more source
Discovery of Quercetin and Its Analogs as Potent OXA-48 Beta-Lactamase Inhibitors
Frontiers in Pharmacology, 2022 Carbapenem resistance in Enterobacteriaceae caused by OXA-48 β-lactamase is a growing global health threat and has rapidly spread in many regions of the world. Developing inhibitors is a promising way to overcome antibiotic resistance. However, there are
Yuejuan Zhang +14 more
doaj +1 more source
OXA-48-Producing Enterobacteriaceae Causing Bacteremia, United Arab Emirates [PDF]
International Journal of Infectious Diseases, 2015 OXA-48-producing isolates were identified in approximately 4% and less than 1% of ESBL-producing and non-ESBL-producing E. coli and K. pneumoniae causing bacteremia at the largest tertiary hospital in Abu Dhabi.
Chulsoo Ahn +7 more
openaire +3 more sources
Heterogeneous hydrolytic features for OXA-48-like β-lactamases [PDF]
Journal of Antimicrobial Chemotherapy, 2015 Abstract Objectives Carbapenem-hydrolysing class D β-lactamases of the OXA-48 type are increasingly reported from Enterobacteriaceae. β-Lactamase OXA-48 hydrolyses penicillins very efficiently, but carbapenems only weakly and spares broad-spectrum cephalosporins.
Oueslati, Saoussen +2 more
openaire +4 more sources
Microbiology Spectrum, 2022 IncX3 and IncL plasmids have been named as catalysts advancing dissemination of blaOXA-181 and blaOXA-48 genes. However, their impact on the performance of host cells is vastly understudied. Genetic characteristics of blaOXA-48- and blaOXA-181-containing
Samiratu Mahazu +11 more
doaj +1 more source
Substrate Specificity of OXA-48 after β5−β6 Loop Replacement [PDF]
ACS Infectious Diseases, 2020 OXA-48 carbapenemase has rapidly spread in many countries worldwide with several OXA-48-variants being described, differing by a few amino acid (AA) substitutions or deletions, mostly in the β5-β6 loop. While single AA substitutions have only a minor impact on OXA-48 hydrolytic profiles, others with 4 AA deletions result in loss of carbapenem ...
Laura Dabos +6 more
openaire +2 more sources
OXA-181 Beta Lactamase is not a Major Mediator of Carbapenem Resistance in Enterobacteriaceae [PDF]
Journal of Clinical and Diagnostic Research, 2013 Background: Detection of carbapenem hydrolyzing class D beta lactamase OXA-181, (a variant of OXA-48) in Enterobacteriaceae, is important, to institute appropriate therapy and to initiate preventive measures.
M. Shanthi +3 more
doaj +1 more source
OXA-48-like carbapenemases producing Enterobacteriaceae in different niches [PDF]
European Journal of Clinical Microbiology & Infectious Diseases, 2017 The emergence of carbapenem-resistant enterobacterial species poses a serious threat to public health worldwide. OXA-48-type carbapenem-hydrolyzing class D β-lactamases are widely distributed among Enterobacteriaceae, with significant geographical differences.
Assia, Mairi +4 more
openaire +2 more sources
OXA-484, an OXA-48-Type Carbapenem-Hydrolyzing Class D β-Lactamase From Escherichia coli
Frontiers in Microbiology, 2021 OXA-48-like carbapenemases are among the most frequent carbapenemases in Gram-negative Enterobacterales worldwide with the highest prevalence in the Middle East, North Africa and Europe.
Julian Sommer +13 more
doaj +1 more source