Results 41 to 50 of about 23,173 (138)

Evaluation of In Vitro Activity of Double-Carbapenem Combinations against KPC-2-, OXA-48- and NDM-Producing Escherichia coli and Klebsiella pneumoniae

Antibiotics, 2022
Double-carbapenem combinations have shown synergistic potential against carbapenemase-producing Enterobacterales, but data remain inconclusive. This study evaluated the activity of double-carbapenem combinations against 51 clinical KPC-2-, OXA-48-, NDM-1,
Lisa Allander, Karin Vickberg, Pernilla Lagerbäck, Linus Sandegren, Thomas Tängdén   +4 more
doaj   +1 more source

Review of In Vitro Efficacy of Ceftazidime-Avibactam, Meropenem-Vaborbactam and Imipenem-Relebactam in Carbapenemase Producing Klebsiella pneumoniae Isolates

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2023
Introduction: To investigate the in vitro efficacy of three new antimicrobial agents [ceftazidime-avibactam (CAZ-AVI), meropenem-vaborbactam (V/R) and imipenem/cilastatin-relebactam] in isolates of carbapenemase-producing Klebsiella pneumoniae (CPKP ...
Özlem AYDEMİR, Mehmet KÖROĞLU, Elif ÖZÖZEN ŞAHİN, Sevinç VURAL   +3 more
doaj   +1 more source

Performance of a new in-house medium Carba MTL-broth for the rapid detection of carbapenemase-producing Enterobacteriaceae

Journal of Infection in Developing Countries, 2019
Introduction: The spread of carbapenemase-producing Enterobacteriaceae (CPE) represents a major public health issue. Methods allowing rapid detection of carbapenemases in developing countries are therefore urgently needed.
Assia Mairi, Abdelaziz Touati, Alix Pantel, Catherine Dunyach-Remy, Albert Sotto, Christophe De Champs, Jean-Philippe Lavigne   +6 more
doaj   +1 more source

Drug Resistance and Molecular Characteristics of Carbapenem-Resistant OXA-48-Producing Klebsiella pneumoniae Strains in Hainan, China

Microorganisms, 2023
Background: The emergence and global spread of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) are of great concern to health services worldwide.
Min Ye, Lei Liu, Bin Liu, Xiangdong Zhou, Qi Li   +4 more
doaj   +1 more source

Molecular epidemiology of OXA-48-producing Klebsiella pneumoniae in France [PDF]

Clinical Microbiology and Infection, 2014
We characterized 53 OXA-48-producing Klebsiella pneumoniae (OXA-48-Kp) isolated between 2011 and 2013 in 21 French hospitals. All the isolates were genotyped using MLST and PFGE and the population structure of the species was determined by a nucleotide-based analysis of the entire K. pneumoniae MLST database.
Liapis, E., Pantel, A., Robert, J., Nicolas-Chanoine, M.-H., Cavalié, L., van Der Mee-Marquet, N., de Champs, C., Aissa, N., Eloy, C., Blanc, V., Guyeux, Christophe, Hocquet, D., Lavigne, J.-P., Bertrand, X., Renseigné, Non   +14 more
openaire   +3 more sources

Genome Sequence of OXA-48 Carbapenemase-Producing Klebsiella pneumoniae KpO3210 [PDF]

Journal of Bacteriology, 2012
ABSTRACT Klebsiella pneumoniae KpO3210 is a OXA-48 carbapenemase-producing isolate obtained from a blood culture in the context of an outbreak in Hospital Universitario La Paz (Madrid, Spain) in 2010. It belongs to the major clone detected during the outbreak and is resistant to all beta-lactams and to several other ...
Jan-Jaap, Wesselink, Elena, López-Camacho, Santiago, de la Peña, Ricardo, Ramos-Ruiz, Guillermo, Ruiz-Carrascoso, Silvia, Lusa-Bernal, Victor M, Fernández-Soria, Rosa, Gómez-Gil, Paulino, Gomez-Puertas, Jesús, Mingorance   +9 more
openaire   +2 more sources

Susceptibility of Clinical Enterobacterales Isolates With Common and Rare Carbapenemases to Mecillinam

Frontiers in Microbiology, 2021
Purpose: To investigate the susceptibility of carbapenemase-producing Enterobacterales (CPE) to mecillinam based on the recently updated European Committee on Antimicrobial Susceptibility Testing (EUCAST) breakpoints for uncomplicated Urinary Tract ...
Frieder Fuchs, Aysel Ahmadzada, Lars Plambeck, Thorsten Wille, Axel Hamprecht, Axel Hamprecht, Axel Hamprecht   +6 more
doaj   +1 more source

Chromosome-mediated OXA-48 carbapenemase in highly virulent Escherichia coli [PDF]

Journal of Antimicrobial Chemotherapy, 2013
Bacteria multiresistant to antibiotics are widely supposed to be weakly virulent. However, the virulence traits of carbapenem-resistant Enterobacteriaceae have not been investigated. In this work, we investigated the virulence and resistance mechanism of an extraintestinal pathogenic Escherichia coli (ExPEC) strain (LEB15) that exhibited decreased ...
Beyrouthy, Racha, Robin, Frederic, Cougnoux, Antony, Dalmasso, Guillaume, Darfeuille-Michaud, Arlette, Mallat, Hassan, Dabboussi, Fouad, Hamze, Monzer, Bonnet, Richard   +8 more
openaire   +4 more sources

Clinical outcomes of phenotype-guided treatment in group D carbapenemase-producing Enterobacterales bacteremia

Microbiology Spectrum
International guidance recommends ceftazidime-avibactam for OXA-48-type carbapenemase-producing Enterobacterales (OXA-48-CPE) infections. However, OXA-48-CPE lacking extended spectrum and AmpC β-lactamases may remain susceptible to third-generation ...
Jinghao Nicholas Ngiam, Matthew Chung Yi Koh, Nicholas Jian Hao Chan, Jeanette Teo, Ka Lip Chew   +4 more
doaj   +1 more source

OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs

mSphere, 2019
Infections due to carbapenemase-producing Gram-negative pathogens are associated with limited treatment options and consequently lead to increased mortality and morbidity.
Christopher Fröhlich, Vidar Sørum, Ane Molden Thomassen, Pål Jarle Johnsen, Hanna-Kirsti S. Leiros, Ørjan Samuelsen   +5 more
doaj   +1 more source