Results 91 to 100 of about 41,732 (296)

Exploration and Characterization of the Antimalarial Activity of Pyrimidine‐2,4‐Diamines for which Resistance is Mediated by the ABCI3 Transporter

ChemMedChem, Volume 21, Issue 1, January 2026.
Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri, Madeline G. Dans, Zijun Low, Katie Loi, Kate E. Jarman, Jocelyn S. Penington, Deyun Qiu, Adele M. Lehane, Benigno Crespo, Franciso‐Javier Gamo, Delphine Baud, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs   +14 more
wiley   +1 more source

A Hybrid Photo/Biocatalytic System for the Sustainable Synthesis of L‐Alanine From Urea and Pyruvate

ChemSusChem, Volume 19, Issue 2, January 2026.
We present a visible‐light driven photo‐biocatalytic system combining urease (URE), L‐alanine dehydrogenase (AlDH) and visible‐light driven nicotinamide adenine dinucleotide (NADH) regeneration system consisting of triethanolamine (TEOA), zinc meso‐tetra(4‐sulfonatophenyl)porphyrin tetrasodium salt (ZnTPPS4‐) and [Cp*Rh(bpy)(H2O)]2+.
Kyosuke Yamada, Yutaka Amao
wiley   +1 more source

Synthesis and Antimicrobial Activity of Some Derivatives on the Basis (7-hydroxy-2-oxo-2H-chromen-4-yl)-acetic Acid Hydrazide

Molecules, 2006
(7-Hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid hydrazide (2) was prepared from (7-hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid ethyl ester (1) and 100% hydrazine hydrate.
Elizabeth Has-Schon, Frane Cacic, Mladen Trkovnik, Milan Cacic   +3 more
doaj   +1 more source

Ketohydrazone complexes as potential emitting material in OLED [PDF]

, 2008
Ketohydrazone is a molecule that is able to act as a bidentate ligand through the O of C=O and N of N=C in the molecule. Three ketohydrazone ligands had been fully synthesized through the condensation reaction between 2- hydroxynaphthaldehydes with ...
Bahari, Haznita Rose, Garif, Mohd. Nordin, Shamsuddin, Mustaffa   +2 more
core  

Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry

ChemistryOpen, Volume 15, Issue 1, January 2026.
Piperazine‐based bioactive molecules represent a versatile class of compounds with broad therapeutic potential. Structural modification of the piperazine scaffold governs key structure–activity relationships, enabling antibacterial, antifungal, antitumor, neuroactive, and anti‐inflammatory activities.
Assel Ten, Raushan Koizhaiganova, Dilnaz Bissenbay, Bagila Tursynova, Zhanar Zhaxibayeva, Valentina Yu   +5 more
wiley   +1 more source

Design of Energetic Materials Based on Asymmetric Oxadiazole

ChemistryOpen, 2019
A new family of asymmetric oxadiazole based energetic compounds were designed. Their electronic structures, heats of formation, detonation properties and stabilities were investigated by density functional theory.
Prof. Xinghui Jin, Dr. Menghui Xiao, Prof. Jianhua Zhou, Prof. Guowei Zhou, Prof. Bingcheng Hu   +4 more
doaj   +1 more source

Conjugated Oligo-Aromatic Compounds Bearing a 3,4,5-Trimethoxy Moiety: Investigation of Their Antioxidant Activity Correlated with a DFT Study

Molecules, 2016
A series of heterocyclic compounds bearing the well-known free radical scavenging 3,4,5-trimethoxybenzyloxy group, was synthesized. The key compound 4-(3,4,5-trimethoxybenzyl-oxy)benzohydrazide was converted into thiosemicarbazide derivatives, which were
Huda. S. Kareem, Nurdiana Nordin, Thorsten Heidelberg, Azlina Abdul-Aziz, Azhar Ariffin   +4 more
doaj   +1 more source

A New Class of Benzo[b]Thiophene‐1,3,4‐Oxadizole Bearing 1,2,4‐Oxadiazoles as Potent Antimicrobial Targets: Synthesis, Biological Evaluation, Docking, DFT and ADMET Studies

ChemistrySelect, Volume 11, Issue 3, 22 January 2026.
Benzo[b]thiophene‐1,3,4‐oxadizole and 1,2,4‐oxadiazole hybrids 9a–9l were tested against both antibacterial and anticancer, revealing interesting structure‐activity relationships. density functional theory calculations (DFTs) at the B3LYP/6–311++G (d,p).
Ravikumar Gupta Miriyala, Janardan Sannapaneni, Phani Raja Kanuparthy, Venkata Ramana Singamaneni, Tejeswara Rao Allaka, Pilli Veera Venkata Nanda Kishore   +5 more
wiley   +1 more source

Synthesis and Evaluation of New Pyrazoline Derivatives as Potential Anticancer Agents

Molecules, 2015
New pyrazoline derivatives were synthesized and evaluated for their cytotoxic effects on AsPC-1 human pancreatic adenocarcinoma, U87 and U251 human glioblastoma cell lines.
Muhammed Karabacak, Mehlika Dilek Altıntop, Halil İbrahim Çiftçi, Ryoko Koga, Masami Otsuka, Mikako Fujita, Ahmet Özdemir   +6 more
doaj   +1 more source

Dual Acting Polymeric Nano-Aggregates for Liver Cancer Therapy [PDF]

, 2018
Liver cancer treatments are often hindered by poor drug physicochemical properties, hence there is a need for improvement in order to increase patient survival and outlook.
Al-Shakarchi, W, Alsuraifi, A, Curtis, A, Hoskins, C   +3 more
core   +4 more sources